A5079797414- Mechanical Circulatory Support Devices
- Acute Myocardial Infarction Research
- Cardiac Arrest and Resuscitation
- Cardiac Structural Anomalies and Repair
- Heart Failure Treatment and Management
- Sepsis Diagnosis and Treatment
- Atrial Fibrillation Management and Outcomes
- Coronary Interventions and Diagnostics
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac electrophysiology and arrhythmias
- Venous Thromboembolism Diagnosis and Management
- Cardiac pacing and defibrillation studies
- Cardiac Valve Diseases and Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Imaging and Diagnostics
- Blood Coagulation and Thrombosis Mechanisms
- Cardiac Arrhythmias and Treatments
- COVID-19 and healthcare impacts
- Protease and Inhibitor Mechanisms
- Cardiovascular Syncope and Autonomic Disorders
- Healthcare cost, quality, practices
- Heparin-Induced Thrombocytopenia and Thrombosis
- Infective Endocarditis Diagnosis and Management
- Blood Pressure and Hypertension Studies
- Heart Rate Variability and Autonomic Control
Wilhelminen Hospital
2013-2024
University of Göttingen
2024
Justus-Liebig-Universität Gießen
2024
Humboldt-Universität zu Berlin
2024
Leibniz-Centre for Contemporary History
2023
University of Potsdam
2023
British Heart Foundation
2022
University of Leeds
2022
Wiener Krankenanstaltenverbund
2022
Centre Hospitalier Universitaire de Lille
2021
Introduction: Infarction-related cardiogenic shock (ICS) is usually due to leftventricular pump failure.With a mortality of 30% 80%, ICS the most common cause death from acute myocardial infarction.The S3 guideline presented here characterizes current evidence-based treatment ICS: early revascularization, shock, and intensive care multi-organ dysfunction syndrome (MODS) if it arises.The success or failure for MODS determines outcome in ICS.
Abstract Aims Concomitant cardiac amyloidosis (CA) in severe aortic stenosis (AS) is difficult to recognize, since both conditions are associated with concentric left ventricular thickening. We aimed assess type, frequency, screening parameters, and prognostic implications of CA AS. Methods results A total 191 consecutive AS patients (81.2 ± 7.4 years; 50.3% female) scheduled for transcatheter valve replacement (TAVR) were prospectively enrolled. Overall, 81.7% underwent complete assessment...
Objective To compare the rate-lowering effect of diltiazem and two amiodarone regimens in critically ill patients with recent-onset atrial tachyarrhythmias. Design Prospective, randomized, controlled study. Setting Medical cardiologic intensive care unit a university hospital. Patients Sixty (Acute Physiology Chronic Health Evaluation [APACHE] III score 70 ± 30, age 67 10 yrs). Interventions fibrillation (n = 57), flutter 2), or tachycardia 1, heart rate consistently >120 beats/min over 30...
Background Subcutaneously administered low-molecular-weight heparins are widely used for prevention of venous thromboembolism. The appropriateness the subcutaneous route in critically ill patients has never been established. Objective To determine anti-Xa activities and noncritically receiving prophylactic doses enoxaparin. Design Prospective, controlled, open-labeled study. Setting Tertiary medical-cardiologic-postoperative intensive care unit a general medical ward at university hospital....
In patients with septic shock, multiple organ failure (MOF) is associated high levels of interleukin-6 (IL-6). Although also a common complication cardiogenic shock (CS), IL-6 have been reported to be lower in CS than shock. We studied plasma respect failure.Eight-bed intensive care unit at university hospital.Fifty-one CS, 26 and 11 noncritically ill controls.None.Patients had higher controls ( p<.001) but p=.003). MOF the time blood sampling exhibited, however, without failure, correlated...
Background: Levosimendan, a novel inodilator, has been shown to improve hemodynamic function in patients with decompensated heart failure preserved arterial blood pressure. Data on its use cardiogenic shock are rare. The present series describes the 24‐h effects of levosimendan as add‐on therapy desperately ill requiring catecholamines. Methods: Ten received continuous infusion 0.1 µg kg −1 min for 24 h. were otherwise unselected. Hemodynamic measurements routinely performed at baseline...
Inflammation may play an important role in the pathogenesis, persistence, and prognosis of cardiogenic shock. We analyzed whether elevated plasma concentrations inflammatory markers are independently associated with adverse (increased 30-day mortality rate) patients shock.Retrospective study.Single-center study, eight-bed intensive care unit at a university hospital.Retrospective study on stored samples from 38 shock complicating acute myocardial infarction.None.Thirty-day nonsurvivors (n =...
Elevated cytokine levels have been reported after ischemia/reperfusion injury and might cause a systemic inflammatory response syndrome (SIRS) successful cardiopulmonary resuscitation (CPR). It is unknown whether patients with SIRS CPR exhibit higher of soluble adhesion molecules than without or elevation associated outcome CPR. We analyzed the relationships among various CPR-related variables, plasma E- P-selectin, occurrence CPR, development sepsis outcome.Prospective, controlled...
Objective: Plasma N-terminal pro-B-type natriuretic peptide (Nt-pro-BNP) levels are frequently elevated in critically ill patients and associated with an increased mortality. In this study, we determined Nt-pro-BNP cardiogenic shock (CS) evaluated its association clinical hemodynamic parameters 30-day Design: Retrospective study. Setting: Two, eight-bed intensive care units at a university community hospital. Patients: study on stored plasma samples of 58 CS, obtained admission to the unit....
The aim of the study was to evaluate effect concomitant treatment with proton-pump inhibitors (PPIs) and clopidogrel on incidence stent thrombosis, acute coronary syndrome (ACS) death in patients who underwent percutaneous intervention (PCI) implantation. In total, 1,210 under dual antiplatelet therapy, PCI implantation, were included a prospective registry from January 2003 until December 2006. divided retrospectively into those or without long-term PPI (for duration therapy). All-cause...
The majority of NSTEMI burden resides outside high-income countries (HICs). We describe presentation, care, and outcomes by country income classification.
Objectives: Guidelines recommend β-blockers and renin-angiotensin-aldosterone system blockers to improve long-term survival in hemodynamically stable myocardial infarction patients with a reduced left ventricular ejection fraction. The prevalence outcomes associated β blocker therapy ongoing cardiogenic shock is unknown. Design: Secondary analysis of randomized controlled trial. Setting: In lasting more than 24 hours enrolled Tilarginine Acetate Injection Randomized International Study...
Transcatheter aortic valve implantation (TAVI) has become the standard therapy for high-risk and non-operable patients with severe stenosis. However, procedure involves several adverse effects, such as rhythm conduction disturbances. Patients postprocedural left bundle branch block may have an increased mortality risk, whereas preprocedural right display a higher rate of postinterventional bradyarrhythmias.The purpose this study was to investigate occurrence high-degree atrioventricular...
The European Society of Cardiology (ESC) EURObservational Research Programme (EORP) Non-ST-segment elevation myocardial infarction (NSTEMI) Registry aims to identify international patterns in NSTEMI management clinical practice and outcomes against the 2015 ESC Guidelines for acute coronary syndromes patients presenting without ST-segment-elevation. Consecutively hospitalised adult (n = 3620) were enrolled between 11 March 2019 6 2021, individual patient data prospectively collected at 287...
Increased platelet turnover and high reactivity are associated with short-term major adverse cardiovascular events (MACE) after percutaneous coronary intervention (PCI) for acute syndrome (ACS) or stable artery disease (SCAD). We investigated the impact of on long-term MACE.Consecutive patients presenting ACS SCAD undergoing PCI between 2009 2010 were included. All received clopidogrel aspirin as dual antithrombotic therapy regimen. Multivariable Cox proportional hazard models applied to...