A5076351586- Cardiovascular Function and Risk Factors
- Cardiac Valve Diseases and Treatments
- Cardiac Imaging and Diagnostics
- Atrial Fibrillation Management and Outcomes
- Cardiac Structural Anomalies and Repair
- Chemotherapy-induced cardiotoxicity and mitigation
- Infective Endocarditis Diagnosis and Management
- Cardiac pacing and defibrillation studies
- Cardiovascular Disease and Adiposity
- Pulmonary Hypertension Research and Treatments
- Cardiovascular Effects of Exercise
- Cardiac Arrhythmias and Treatments
- Influenza Virus Research Studies
- Cardiomyopathy and Myosin Studies
- Viral Infections and Immunology Research
- Lipoproteins and Cardiovascular Health
- Nutrition and Health in Aging
- Muscle Physiology and Disorders
- Cancer Treatment and Pharmacology
- Streptococcal Infections and Treatments
- Pericarditis and Cardiac Tamponade
- Systemic Sclerosis and Related Diseases
- Acute Myocardial Infarction Research
- Cardiac, Anesthesia and Surgical Outcomes
- Mechanical Circulatory Support Devices
Blacktown & Mount Druitt Hospital
2016-2025
UNSW Sydney
2016-2025
Western Sydney University
2016-2025
The University of Sydney
2012-2025
Westmead Hospital
2015-2025
Sydney Local Health District
2020-2025
Hong Kong University of Science and Technology
2025
University of Hong Kong
2025
Harvard University
2012-2023
Massachusetts General Hospital
2012-2023
Background— Because cancer patients survive longer, the impact of cardiotoxicity associated with use treatments escalates. The present study investigates whether early alterations myocardial strain and blood biomarkers predict incident in breast during treatment anthracyclines, taxanes, trastuzumab. Methods Results— Eighty-one women newly diagnosed human epidermal growth factor receptor 2–positive cancer, treated anthracyclines followed by taxanes trastuzumab were enrolled to be evaluated...
Healing after myocardial infarction involves the biphasic accumulation of inflammatory lymphocyte antigen 6C (Ly-6C)(high) and reparative Ly-6C(low) monocytes/macrophages (Mo/MΦ). According to 1 model, Mo/MΦ heterogeneity in heart originates blood sequential recruitment distinct monocyte subsets that differentiate macrophages. Alternatively, may arise tissue from circulating subset via local macrophage differentiation polarization. The orphan nuclear hormone receptor, receptor subfamily 4,...
Abstract Background Long COVID is a complex, heterogeneous syndrome affecting over four hundred million people globally. There are few recommendations, and no formal training exists for medical professionals to assist with clinical evaluation management of patients COVID. More research into the pathology, cellular, molecular mechanisms COVID, treatments needed. The goal this work disseminate essential information about recommendations definition, diagnosis, treatment, social issues...
There is uncertainty in identifying patients with severe aortic stenosis (AS) preserved left ventricular (LV) ejection fraction, low flow, and gradients (LFLG). Prior studies propose that these demonstrate significant concentric remodelling decreased survival, while others suggest they have features survival similar to moderate AS. We compared the clinical characteristics, echocardiographic features, overall of LFLG AS (n = 38) those normal-flow, low-gradient (NFLG) 75) 70). Low-flow, had...
COVID-19 is an independent risk factor for cardiovascular disease. vaccination may prevent this, but in some cases, cause myocarditis or pericarditis. Patients with present non-specific symptoms that have a cardiac origin. This review examines the complications of infection and impact vaccination. include myocardial injury, pericarditis, coagulopathy, infarction, heart failure, arrhythmias, persistent post-acute adverse outcomes. Diagnostic referral pathways symptoms, such as dyspnoea...
Current echocardiographic scoring systems for percutaneous mitral valvuloplasty (PMV) have limitations. This study examined new, more quantitative methods assessing valvular involvement and the combination of parameters that best predicts immediate long-term outcome after PMV.Two cohorts (derivation n=204 validation n=121) patients with symptomatic stenosis undergoing PMV were studied. Mitral valve morphology was assessed by using both conventional Wilkins qualitative novel parameters,...
The aim of this study was to assess whether baseline echocardiographic measures left ventricular (LV) size and function predict the development symptomatic heart failure or cardiac death (major adverse events, MACE) in patients treated with anthracyclines who have a pre-chemotherapy ejection fraction (LVEF) between 50 59%.Patients an LVEF 59% before were selected. In these patients, LV volumes, LVEF, peak longitudinal strain (GLS) measured. Individuals followed for MACE all-cause mortality...
Background— Heart development is tightly regulated by signaling events acting on a defined number of progenitor and differentiated cardiac cells. Although loss function these pathways leads to congenital malformation, the consequences cell or embryonic cardiomyocyte are less clear. In this study, we tested hypothesis that mouse hearts exhibit robust mechanism for regeneration after extensive loss. Methods Results— By combining conditional ablation approach with novel blastocyst...
Abundant, indirect epidemiological evidence indicates that influenza contributes to all-cause mortality and cardiovascular hospitalisations with studies showing increases in acute myocardial infarction (AMI) death during the season.To investigate whether is a significant unrecognised underlying precipitant of AMI.Case-control study.Tertiary referral hospital Sydney, Australia, 2008 2010.Cases were inpatients AMI controls outpatients without at Australia.Primary outcome was laboratory...
Aging | doi:10.18632/aging.100436. Angie M. Y. Shum, Theodore Mahendradatta, Ryland J. Taylor, Arran B. Painter, Melissa Moore, Maria Tsoli, Timothy C. Tan, Stephen Clarke, Graham R. Robertson, Patsie Polly
Myopathy is a feature of many inflammatory syndromes. Chronic inflammation has been linked to pathophysiological mechanisms which implicate 1,25 dihydroxyvitamin D3 (1,25-(OH)2D3)-mediated signaling pathways with emerging evidence supporting role for the vitamin D receptor (VDR) in contractile and metabolic function both skeletal cardiac muscle. Altered VDR expression muscle reported result significant effects on metabolism, calcium fibrosis these tissues. Elevated levels serum cytokines,...
Background— In this study, we looked at the prognostic value of echocardiographic and hemodynamic measures in a large cohort patients with precapillary pulmonary hypertension before after initiation treatment. Methods Results— Data were collected prospectively consecutive referred between 2002 2011. A range clinical variables stored on database to assess predictors survival. Invasive data including artery pressure, vascular resistance, capillary wedge cardiac index also obtained baseline all...
// Angie M. Y. Shum 1, 2, * , Anne Poljak 3, 4, 5, Nicholas L. Bentley 3 Nigel Turner Timothy C. Tan 6 and Patsie Polly 2 1 Mechanisms of Disease Translational Research, School Medical Sciences, Faculty Medicine, UNSW Sydney, New South Wales, Australia Department Pathology, Pharmacology, 4 Bioanalytical Mass Spectrometry Facility, 5 Centre for Healthy Brain Ageing, Psychiatry, Western Clinical Westmead Hospital, Westmead, These authors contributed equally to this work Correspondence to:...