A5047774887- Natural Antidiabetic Agents Studies
- Pomegranate: compositions and health benefits
- Alzheimer's disease research and treatments
- Endoplasmic Reticulum Stress and Disease
- Gastric Cancer Management and Outcomes
- Hemoglobinopathies and Related Disorders
- Iron Metabolism and Disorders
- Pancreatic function and diabetes
- Phytochemicals and Antioxidant Activities
- Lung Cancer Diagnosis and Treatment
- Paraoxonase enzyme and polymorphisms
- Pineapple and bromelain studies
- Sepsis Diagnosis and Treatment
- Tryptophan and brain disorders
- Cutaneous Melanoma Detection and Management
- Polysaccharides and Plant Cell Walls
- Nosocomial Infections in ICU
- Digestive system and related health
- Hemophilia Treatment and Research
- Nonmelanoma Skin Cancer Studies
- Sesame and Sesamin Research
- Vitamin D Research Studies
- Bone and Joint Diseases
- Colorectal Cancer Treatments and Studies
- Public Health in Brazil
CUF Porto Hospital
2025
Universidade Nova de Lisboa
2002-2023
Instituto de Biologia Experimental e Tecnológica
2020-2022
The Netherlands Cancer Institute
2021
Nova Medical (United States)
2021
Institut de Radioprotection et de Sûreté Nucléaire
2020
IPO Porto
2014-2019
Hospital Vila Franca de Xira
2018-2019
Universidade Federal de Goiás
2019
•The TSR is a cost-effective and robust histological parameter scored on routine hematoxylin–eosin-stained slides.•This study prospectively validates the independent prognostic effect of for patients with stage II-III colon cancer.•Stroma-high tumors (i.e. intratumoral stromal percentage >50%) significantly lead to worse DFS.•Stroma-high also exhibit chemotherapy resistance, emphasizing clinical need new therapy strategies.•Implementation in international guidelines improved guidance...
HighlightsAdvanced imaging detects more asymptomatic metastatic esophagogastric cancerThis Delphi study explores optimal timing of initiating treatment in these patientsImmediate start is mostly preferred by European expertsConsensus was to defer older or WHO 2 patients who prefer deferralAbstractBackgroundThe enhanced application techniques resulting the diagnosis with cancer (mEGC). We conducted a gather insights from experts on palliative systemic therapy for patients.MethodsAn online...
Abstract We have analysed, at the hematological and molecular level, 51 Hb lepore heterozygotes three compound for Lepore HbS (HbLep/HbS) in 26 unselected Portuguese families. The Boston variant was present one family, association with classical haplotype V. All of other alleles III Xmn I (+)5′ G γ gene, tight linkage disequilibrium to major mutation found population, Baltimore ( δ 68Leu ‐β 84Thr ). are first HbLep/HbS individuals reported literature, linked III. In agreement studies, these...
Diabetes is a major public health issue that has attained alarming levels worldwide. Pancreatic aggregates of human islet amyloid polypeptide (IAPP) represent histopathological hallmark type 2 diabetes. IAPP expressed in β-cells as pre-pro-IAPP (ppIAPP) first processed to pro-IAPP (pIAPP) and finally its mature form (matIAPP), being released upon glucose stimulation together with insulin. Impairment overload the processing machinery seem be associated accumulation immature species formation...
Introduction Diabetes is one of the major metabolic diseases worldwide. Despite being a complex systemic pathology, aggregation and deposition Islet Amyloid Polypeptide (IAPP), or amylin, recognized histopathological marker disease. Although IAPP proteotoxicity represents an important trigger β-cell dysfunction ultimately death, its exploitation as therapeutic tool remains underdeveloped. The bioactivity (poly)phenols towards inhibition pathological protein well known, however, most...
Abstract Background Venous thromboembolism (VTE) is one of the leading causes death in patients with cancer. Currently, there a need to develop an easily applicable risk model that can identify who will benefit from receiving primary thromboprophylaxis reduce incidence VTE. Patients and methods This was non-interventional, multicenter, observational, prospective study carried out 62 Oncology Hematology services Spain Portugal between January 2018 December 2019. The main objective CARTAGO...
Purpose Depleted uranium (DU) has several civilian and military applications. The effects of this emerging environmental pollutant on human health raise some concerns. Previous experimental studies have shown that (U) exposure can disturb the central nervous system. A small quantity U reaches brain via blood, but blood-brain barrier (BBB) remain unclear.Materials methods In present work, two cell culture models were exposed to DU for different times study its cytotoxicity, paracellular...
Intracellular aggregation and pancreatic deposition of Islet Amyloid Polypeptide (IAPP, or amylin) is an important trigger β-cell dysfunction in type 2 diabetes prevention this process represents attractive strategy to improve functionality. (Poly)phenols, particularly small molecule polyphenol metabolites (SMPMs) resulting from the metabolism by colonic microbiota, have emerged as promising lead molecules.This study aimed identify SMPMs inhibiting IAPP elucidate their activity towards...
Este artigo analisa a possibilidade de uma leitura das personagens Tia Nastácia e Emília da série Sítio do Picapau Amarelo Monteiro Lobato (1931). Neste estudo investigamos analogia entre essas que possibilitam enxergar em sua relação situação autor obra, já é responsável pela confecção na narrativa. A partir deste olhar concepções Análise Discurso Linha Francesa, discutimos, baseados nos conceitos autor/obra trabalhados por Bakhtin/Volochínov (2013-2014) Foucault (2002), como se encontra,...
Pancreatic deposition of Islet Amyloid PolyPeptide (IAPP) is a histopathological hallmark type 2 diabetes. Inadequate processing immature IAPP by proprotein convertases (PCs) leads to the accumulation unprocessed forms, which in turn favors increased aggregate formation pancreatic β-cells. Kexin (Kex2) Saccharomyces cerevisiae prototype eukaryotic PCs family, but date no direct correlations between Kex2 activity and preproIAPP yeast have been reported. In this study we aimed address possible...
Despite the progresses in therapeutics, type 2 diabetes is still an epidemic with alarming numbers worldwide. New strategies for prevention and treatments are imperative. A venue of research potential aggregation Islet Amyloid PolyPeptide (IAPP), a contributor to pancreatic β-cell dysfunction. To address impact IAPP on calcium (Ca2+) signalling, we developed dual reporter yeast model independently expressing preproIAPP-GFP (ppIAPP) encoding lacZ gene under control Crz1-recognition elements....