A5037798552- Glioma Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Radiomics and Machine Learning in Medical Imaging
- Ferroptosis and cancer prognosis
- Healthcare during COVID-19 Pandemic
- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Pancreatic and Hepatic Oncology Research
- HIV/AIDS oral health manifestations
- Immune cells in cancer
- Treatment of Major Depression
- Cerebrovascular and Carotid Artery Diseases
- Protein Degradation and Inhibitors
- Occupational Health and Burnout
- Women's cancer prevention and management
- DNA Repair Mechanisms
- Cancer-related Molecular Pathways
- TGF-β signaling in diseases
- Metastasis and carcinoma case studies
- RNA regulation and disease
- Angiogenesis and VEGF in Cancer
- Science and Education Research
- Brain Metastases and Treatment
Hospital Braga
2014-2021
Victor (Japan)
2014
Hospital de São Marcos
2007-2011
Universidade do Porto
2011
University of Minho
2011
Malignant gliomas are the most prevalent type of primary brain tumours but therapeutic armamentarium for these is limited. Platelet-derived growth factor (PDGF) signalling has been shown to be a key regulator glioma development. Clinical trials evaluating efficacy anti-PDGFRA therapies on ongoing. In this study, we intended analyse expression PDGFA and its receptor PDGFRA, as well underlying genetic (mutations amplification) mechanisms driving their in large series human gliomas.PDGFA PDGFRA...
Objetivo: Analisar a efetividade da vacinação contra o HPV em crianças e adolescentes de 9 14 anos município mineiro, entre 2018 2022. Metodologia: Estudo epidemiológico descritivo transversal, baseado dados do Sistema Informação Imunizações Programa Nacional (SI-PNI). Os vacinais foram analisados retrospectivamente apresentados tabelas gráficos, considerando ano, meta cobertura vacinal doses aplicadas. Resultados: Em 2018, apenas 16,54% (N=1025) receberam primeira dose (D1) 14,59% (N=904)...
Abstract Background: The epidermal growth factor receptor (EGFR) regulates important cellular processes and is frequently implicated in human tumors. Three EGFR polymorphisms have been described as having a transcriptional regulatory function: two single-nucleotide the essential promoter region, −216G/T −191C/A, polymorphic (CA)n microsatellite sequence intron 1. We aimed to elucidate roles of these glioma susceptibility prognosis. Methods: conducted case–control study with 196 patients 168...
Both genetic and environmental factors are thought to be causal in gliomagenesis. Several genes have been implicated glioma development, but the putative role of a major immunity-related gene complex member, immunoglobulin heavy chain γ (IGHG) has not evaluated. Prior observations that IGHG-encoded marker (GM) allotypes exhibit differential sensitivity an immunoevasion strategy cytomegalovirus, pathogen as promoter gliomagenesis, lead us hypothesize these determinants risk for glioma. To...
Transforming growth factor beta (TGF-β) plays an important role in carcinogenesis. Two polymorphisms the TGF-β1 gene (-509C/T and 869T/C) were described to influence susceptibility gastric breast cancers. The 869T/C polymorphism was also associated with overall survival cancer patients. In present study, we investigated relevance of these glioma risk prognosis. A case-control study that included 114 patients 138 cancer-free controls performed. Single nucleotide (SNPs) evaluated by polymerase...
The vascular endothelial growth factor regulates angiogenesis that is increased in glioma. VEGF polymorphisms are thought to modulate plasma levels and therefore may be implicated glioma risk. We aimed clarify the role of von Willebrand susceptibility prognosis. A case–control study 126 patients 180 cancer-free controls was performed. Using Sequenom MassARRAY platform, 11 1 VWF were genotyped. Unconditional multivariate logistic regression models used calculate odds ratios 95% confidence...
Os primeiros casos de COVID-19 apareceram em Wuhan novembro 2019. Após vários estudos, foi possível relacionar que o quadro pode ser agravado pacientes apresentam comorbidades tal qual a hipertensão. Alterações na disposição dos genes, levam doenças por polimorfismos, podem alterar atuação do vírus dentro corpo humano. Por meio uma revisão narrativa da literatura desenvolvida neste trabalho, conseguiu-se observar hipertensão, tinham mais chance desenvolver grave COVID-19, inclusive evoluindo...
Abstract Background Venous thromboembolism (VTE) is one of the leading causes death in patients with cancer. Currently, there a need to develop an easily applicable risk model that can identify who will benefit from receiving primary thromboprophylaxis reduce incidence VTE. Patients and methods This was non-interventional, multicenter, observational, prospective study carried out 62 Oncology Hematology services Spain Portugal between January 2018 December 2019. The main objective CARTAGO...
Introduction: Drug-induced increased libido has been reported mainly with dopaminergic agents. Although benzodiazepines may cause behavioural dishinibition, they were rarely related to sexual undesired urges. Case: A 62-year-old woman was seen for breast mucinous carcinoma. Besides mild hypertension and initial insomnia she otherwise previously healthy. She chronically medicated ramipril diazepam 5mg id. Tumour ressection carried out chemotherapy FEC-T began. One week after, in a follow-up...
<div>Abstract<p><b>Background:</b> The epidermal growth factor receptor (EGFR) regulates important cellular processes and is frequently implicated in human tumors. Three <i>EGFR</i> polymorphisms have been described as having a transcriptional regulatory function: two single-nucleotide the essential promoter region, −216G/T −191C/A, polymorphic (CA)<sub>n</sub> microsatellite sequence intron 1. We aimed to elucidate roles of these glioma...
<div>Abstract<p><b>Background:</b> The epidermal growth factor receptor (EGFR) regulates important cellular processes and is frequently implicated in human tumors. Three <i>EGFR</i> polymorphisms have been described as having a transcriptional regulatory function: two single-nucleotide the essential promoter region, −216G/T −191C/A, polymorphic (CA)<sub>n</sub> microsatellite sequence intron 1. We aimed to elucidate roles of these glioma...
Relatamos o caso de um doente com diagnóstico gliomatose cerebral que após dois quadros hipertensão intracraniana grave, iniciou quimioterapia paliativa e evoluiu forma clínica imagiologicamente satisfatória. Doente 33 anos idade, previamente autónomo (Karnofsky Performance Status Scale 100 pontos) sem antecedentes pessoais/familiares relevantes. É investigado tomografia computorizada ressonância magnética no contexto crise convulsiva inaugural. detetada uma lesão infiltrativa...