A5059784281- Prostate Cancer Treatment and Research
- Chemistry Education and Research
- Chemistry and Chemical Engineering
- Various Chemistry Research Topics
- Prostate Cancer Diagnosis and Treatment
- Inorganic and Organometallic Chemistry
- Radiopharmaceutical Chemistry and Applications
- Cancer Diagnosis and Treatment
- Cancer Treatment and Pharmacology
- Management of metastatic bone disease
- History and advancements in chemistry
- Environmental Chemistry and Analysis
- Phosphorus compounds and reactions
- Inflammatory Biomarkers in Disease Prognosis
- COVID-19 and healthcare impacts
- Glioma Diagnosis and Treatment
- Brain Metastases and Treatment
- Lung Cancer Treatments and Mutations
- Global Cancer Incidence and Screening
- Thermal and Kinetic Analysis
- Multiple Myeloma Research and Treatments
- Bone health and treatments
- Chemotherapy-related skin toxicity
- PARP inhibition in cancer therapy
- Quinazolinone synthesis and applications
Unidade Hospitalar de Bragança
2024
Hospital Braga
2022-2024
Western University
2021-2023
London Health Sciences Centre
2021-2023
Cancer Care Ontario
2021-2022
Lawson Health Research Institute
2022
Universidade do Porto
1970-2021
Ottawa Hospital
2016-2017
Ottawa Hospital Research Institute
2017
University of Ottawa
2016
Abstract Background: The epidermal growth factor receptor (EGFR) regulates important cellular processes and is frequently implicated in human tumors. Three EGFR polymorphisms have been described as having a transcriptional regulatory function: two single-nucleotide the essential promoter region, −216G/T −191C/A, polymorphic (CA)n microsatellite sequence intron 1. We aimed to elucidate roles of these glioma susceptibility prognosis. Methods: conducted case–control study with 196 patients 168...
New quinazolinone derivatives of the marine-derived alkaloids fiscalin B (3) and fumiquinazoline G (1), with neuroprotective antitumor effects, were synthesized. Eleven quinazolinone-containing indole synthesized, proceeding anti analogs via a one-pot method, syn by Mazurkiewicz-Ganesan approach. The neuroprotection capacity these compounds on rotenone-damage human neuroblastoma cell SH-SY5y was evaluated using MTT assay. Compounds 1, 3, 5, 7 showed more than 25% protection. activity...
Management of advanced prostate cancer has evolved rapidly with the availability multiple systemic treatments such as androgen-receptor axis-targeted therapies (ARATs), taxane-based chemotherapy, radium-223, and other approaches. However, limited data exists on real-world treatment selection clinical outcomes. This study examines utilization survival impact these in men metastatic castration-resistant (mCRPC) setting Ontario, Canada. was a retrospective, longitudinal, population-based...
Bone-targeting agents (BTAs), such as bisphosphonates and denosumab, have demonstrated no discernable effects on tumour response or disease free/overall survival in patients with bone metastases from breast cancer. Doxycycline is both osteotropic has anti-cancer effects. When combined zoledronate animal models, doxycycline showed significantly increased inhibition of burden formation. We evaluated the adding to ongoing therapy metastatic Breast cancer ≥3 months BTA use, entered this...
De novo cases of metastatic prostate cancer (mCSPC) are associated with poorer prognosis. To assist in clinical decision-making, we aimed to determine the prognostic utility commonly available laboratory-based markers overall survival (OS). In a retrospective population-based study, cohort 3556 men aged ≥66 years diagnosed de mCSPC between 2014 and 2019 was identified Ontario (Canada) administrative database. OS assessed by using Kaplan–Meier method. Multivariate Cox regression analysis...
Recurrent or metastatic head and neck squamous cell carcinoma (R/M HNSCC) is a challenging disease, requiring personalized management by multidisciplinary team. The aim of this retrospective multicentric study was to characterize real-world healthcare resource use patient care for R/M HNSCC in Portugal during the first year after diagnosis. A total 377 patients ineligible curative treatment were included, mostly male (92.8%), aged 50–69 years (74.5%), with heavy alcohol (72.7%) smoking...
To describe patterns of practice PSA testing and imaging for Ontario men receiving continuous ADT the treatment non-metastatic castration-resistant prostate cancer (nmCRPC).
Despite advances in therapy, bone remains the most common site of prostate cancer recurrence [...]
Cancer care providers have faced many challenges in delivering safe for patients during the COVID-19 pandemic. This cross-sectional survey-based study investigated impact of pandemic on clinical practices Portuguese medical oncologists caring with breast cancer.An anonymous online survey comprising 42 questions gathered information regarding testing, treatment (neo)adjuvant and metastatic settings, other aspects cancer management. Practices before were compared, potential differences...
e13526 Background: The incidence of leptomeningeal carcinomatosis (LC) in breast cancer patients (LC-BC) is rising. Despite significantly impacting patient survival and quality life (QoL), little known about its optimal management. A systematic review treatment strategies for LC-BC was performed. Methods: EMBASE, Ovid Medline(R), Pubmed, the Cochrane Central Register Controlled Trials were searched from 1946 to September 2015 trials reporting on treatments LC-BC. All modalities considered....
This article is based on the idea that immersive journalism in virtual worlds, specifically Second Life, has similarities with online journalism. To sustain this premise, literature reviewed will follow debate about Internet, writing and reporting across new media, speculate a concept of worlds growing, as an example trend journalistic practice. Questions such legitimacy forms journalism, especially pertinence environments, where they may be put to practice, addressed. Consequently, focus...
Non-metastatic castration-resistant prostate cancer (nmCRPC) represents a challenging disease state in care. nmCRPC patients with high risk of progression to metastatic who are identified by prostate-specific antigen doubling time (PSADT) ≤10 months eligible for treatment the novel androgen receptor inhibitors (ARIs), shown delay and extend survival. However, is often unexploited clinical practice due lack standardization methodology tools used its identification. In this article, group...
O efeito fotoelétrico é um fenómeno no qual são emitidos eletrões de material, geralmente metálico, quando iluminado com radiação frequência conveniente.
O catalisador é uma substância que aumenta a velocidade de reação, mas não consumido ao longo desta. Um reacção química, vez baixa energia ativação (Ea) da através alteração do mecanismo reacional, fornecendo assim um caminho alternativo evita o passo lento determina reação catalisada (figura 1).
Etimologicamente, electrólise significa "decomposição pela electricidade". A é, assim, um processo que utiliza corrente eléctrica para promover uma reacção química não espontânea. Para isso, gerador de contínua é ligado aos eléctrodos célula electrolítica forçando os electrões a participar em reacções provocadas oxidação num dos (o ânodo) e redução no outro eléctrodo cátodo).