A5090495885- Head and Neck Cancer Studies
- Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Cancer survivorship and care
- Bladder and Urothelial Cancer Treatments
- Inflammatory Bowel Disease
- Colorectal Cancer Treatments and Studies
- Gastrointestinal Bleeding Diagnosis and Treatment
- Cancer Treatment and Pharmacology
- Urinary and Genital Oncology Studies
- Brain Metastases and Treatment
- Diverticular Disease and Complications
- Gastric Cancer Management and Outcomes
- Radiomics and Machine Learning in Medical Imaging
- Metastasis and carcinoma case studies
- Urological Disorders and Treatments
- Cancer Immunotherapy and Biomarkers
- HER2/EGFR in Cancer Research
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Cancer Genomics and Diagnostics
- Advanced Breast Cancer Therapies
- COVID-19 and healthcare impacts
- Animal Genetics and Reproduction
- Lung Cancer Research Studies
- Immunotherapy and Immune Responses
Algarve Biomedical Center
2021-2024
Administração Regional de Saúde de Lisboa e Vale do Tejo
2024
Centro Hospitalar do Porto
2012-2023
Instituto Português de Oncologia de Coimbra Francisco Gentil
2020-2023
Hospital da Senhora da Oliveira Guimarães
2023
Centro Hospitalar de Vila Nova de Gaia
2023
Hospital de São João
2023
Hospitais da Universidade de Coimbra
2023
Instituto Português de Oncologia Francisco Gentil
2021
University of Minho
2018
Iron deficiency anemia remains one of the main indications to perform small bowel capsule endoscopy. Literature suggests that diagnostic yield is influenced by patient's age but with conflicting results regarding cutoff.We aimed clarify differences in and incidence specific findings according age.Retrospective single-center study including 118 patients performing endoscopy iron anemia. Videos were reviewed may account for reported. Incomplete examinations excluded. Findings compared between...
Recurrent or metastatic head and neck squamous cell carcinoma (R/M HNSCC) is a challenging disease, requiring personalized management by multidisciplinary team. The aim of this retrospective multicentric study was to characterize real-world healthcare resource use patient care for R/M HNSCC in Portugal during the first year after diagnosis. A total 377 patients ineligible curative treatment were included, mostly male (92.8%), aged 50–69 years (74.5%), with heavy alcohol (72.7%) smoking...
14030 Background: Nimotuzumab (N) is a humanized mAb against the EGFR extracellular ligand binding domain. Although well tolerated when combined with radiotherapy in previous studies and lacking usual toxicities of EGFR-targeting agents, pharmacodynamics (PD) N has not been elucidated. This phase I study was designed to evaluate safety, tolerability PD N. Methods: Eligibility criteria included advanced solid tumors refractory standard therapy ECOG PS = 0 - 2. IV administered weekly x 6 then...
Background: The term phyllodes tumours, which account for less than 1% of breast neoplasms, describes a spectrum heterogenous tumours with different clinical behaviours. Less 30% present as metastatic disease. Complete surgical resection is the standard care so that recurrence rates are reduced. role adjuvant chemotherapy or radiation therapy controversial. Patients disease have median overall survival around 30 months. Case description: authors case 57-year-old woman an exuberant left...
Introduction Geriatric oncology underscores the significance of assessing functional age in guiding medical decisions, endeavouring to delineate practical and efficacious methodologies for evaluating functionality, adapting therapeutic regimens attenuating risks treatment-related deterioration. Objectives Methods In this prospective study, we aimed characteristics older patients presenting their initial appointment by using geriatric screening (G8 score) comprehensive assessment (CGA), while...
Background: Capsule panendoscopy is increasingly used in Crohn's disease (CD), particularly patients with extensive small bowel and colonic involvement. It offers a non-invasive, 1-step evaluation of both segments, making it appealing for monitoring treatment response. However, there need validated scoring systems that objectively assess inflammatory activity the colon. The aim this study was to externally validate Eliakim Score (Elk-S), developed mucosal inflammation CD by capsule...
Introduction: Colorectal cancer (CRC) is the second-most deadly worldwide. However, there remains a scarcity of precision treatments available for this type cancer. Amplification or overexpression human epidermal growth factor receptor 2 (HER2+) well-established therapeutic target in gastric and breast HER2 positive approximately 5% CRC cases has been implicated resistance to therapy with anti-epidermal antibodies. The aim study was evaluate status RAS BRAF wild-type metastatic (mCRC) its...
The RECOURSE trial supported trifluridine/tipiracil as a treatment option in metastatic colorectal cancer (mCRC). Subsequent analysis demonstrated that low tumour burden and indolent disease are good prognosis factors improving progression-free survival (PFS) overall (OS). This study aimed to evaluate the impact of group OS, PFS safety patients with mCRC. Single-centre, retrospective, observational mCRC who started between February 2018 July 2019. Patients were divided into characteristics...
Tumor-infiltrating lymphocytes (TILs) have shown prognostic value in breast cancer. This study evaluated the TILs scores 186 Portuguese patients diagnosed with early cancer, special focus on HER2 subtype. Stromal were scored core needle biopsies, as well resected specimen HER2+ submitted to neoadjuvant treatment trastuzumab and pertuzumab. higher tumors negative hormone receptor status amplifications, triple-negative In treated dual anti-HER therapy, score surgical was generally lower than biopsy.
Over the last years, incidence of brain metastases in HER2 breast cancer patients has increased. Surgery and radiotherapy are current standard local therapies. Nevertheless, it is unclear which when systemic treatment should be applied addition to treatment. This work aims present an updated review options for with HER2+ metastatic a case study clinical cases that occurred Portuguese population. The methodology this included literature search PubMed impact HER2-targeting agents, such as...
Abstract BACKGROUND Glioblastoma (GBM) is the most common and aggressive primary malignant brain tumour in adults. The current standard of care for newly diagnosed GBM maximal surgical resection, followed by radiotherapy plus concomitant adjuvant temozolomide (TMZ). This study aimed to evaluate survival outcomes identify predictors among these patients. MATERIAL AND METHODS We performed a single-centre retrospective analysis patients treated with TMZ from 2013 2020. analyses progression-free...
Epithelioid trophoblastic tumour (ETT) is a very rare variant of gestational disease, which arises in reproductive-age women with prior history. Because its rarity, biological behaviour, imaging characteristics and therapeutic schedule have not yet been fully established. Here we describe case metastatic ETT premenopausal woman. A 40-year-old, gravida 3, para 2, Portuguese woman was referred to the dermatology department for multiple skin nodules on scalp measuring between 1 6 cm. biopsy...
Introduction: SHOX gene (short stature homeobox gene) deficiency is one of the most frequent genetic causes isolated or familial short stature, with highly variable clinical severity.Case-report: The authors describe a 14 year-old-girl, limbs and stature. wrist X-ray showed Madelung deformity. molecular study deletion (FISH del (X) (Xp22.3Xp22.3) (SHOX). A very careful physical examination, including measurement body proportions, extreme importance in evaluation deformity can only appear...