A5031727838- Head and Neck Cancer Studies
- Gastric Cancer Management and Outcomes
- Metastasis and carcinoma case studies
- Brain Metastases and Treatment
- Cancer Diagnosis and Treatment
- Cancer Cells and Metastasis
- Lung Cancer Treatments and Mutations
- Ferroptosis and cancer prognosis
- Barrier Structure and Function Studies
- Breast Cancer Treatment Studies
- HER2/EGFR in Cancer Research
- Multiple and Secondary Primary Cancers
- BRCA gene mutations in cancer
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Glioma Diagnosis and Treatment
- Tracheal and airway disorders
- Cancer Genomics and Diagnostics
- Cancer-related cognitive impairment studies
- Central Venous Catheters and Hemodialysis
- Viral-associated cancers and disorders
- Acute Myocardial Infarction Research
- Chemotherapy-induced cardiotoxicity and mitigation
- Colorectal and Anal Carcinomas
- Sex and Gender in Healthcare
- Oral health in cancer treatment
Instituto Português de Oncologia de Coimbra Francisco Gentil
2015-2025
University of Lisbon
2021-2024
Vall d'Hebron Institute of Oncology
2023
Instituto Português de Oncologia Francisco Gentil
2015-2021
Locally advanced head and neck squamous cell carcinoma (HNSCC) is treated with definitive concurrent chemoradiation if deemed unresectable. Contrarily to the metastatic/recurrent setting, there no current role for immunotherapy in locally all trials being negative their primary endpoints. As such, although it may still be performed, determination of programmed death-ligand 1 (PD-L1) not mandatory disease. We aimed assess was any correlation PD-L1 positivity (when obtained), disease...
Bioactives from Mediterranean diet (MD), hydroxytyrosol (HT), tyrosol (TYRS), serotonin (SER) and protocatechuic acid (PCA) cross the blood-brain barrier (BBB) do not impair its integrity.
Breast cancer (BC) brain metastases is a life-threatening condition to which accounts the poor understanding of BC cells' (BCCs) extravasation into brain, precluding development preventive strategies. Thus, we aimed unravel players involved in interaction between BCCs and blood-brain barrier (BBB) endothelial cells underlying BBB alterations transendothelial migration malignant cells. We used microvascular (BMECs) as vitro model, under conditions mimicking shear stress improve vivo-like...
In patients with recurrent or metastatic head and neck squamous cell carcinoma (R/M HNSCC) the estimated prognosis is usually poor. Patient-specific factors that affect should be considered when choosing therapy. We conducted a retrospective, single-center analysis in treated first line platinum antiEGFR antibody-containing regimen. The objective was to generate real-world data considering treatment outcomes identify predictors of survival.Clinical charts cetuximab platinum-based...
Agrifood by-products and microalgae represent a low-cost valuable source of bioactive compounds with neuroprotective properties. However, the effectiveness therapeutic molecules can be limited by their capacity to cross blood–brain barrier (BBB) reach brain. In this research, various green extracts from Robinia pseudoacacia (ASFE), Cyphomandra betacea (T33), Coffea arabica (PPC1), Olea europaea L., (OL-SS), Citrus sinensis (PLE100) Dunaliella salina (DS) that have demonstrated in vitro...
Among breast cancer (BC) subtypes, the most aggressive is triple negative BC (TNBC), which prone to metastasis. We previously found that microRNA (miR)-194-5p downregulated at early stages of TNBC brain metastasis development. Additionally, transcription factor myocyte enhancer 2 (MEF2)C, a bioinformatically predicted miR-194-5p target, was increasingly expressed throughout formation and disease severity. However, contributions these two players malignant cells' features remain undetermined....
Among breast cancer (BC) patients, 15-25% develop BC brain metastases (BCBM), a severe condition due to the limited therapeutic options, which points need for preventive strategies. We aimed find drug able boost blood-brain barrier (BBB) properties and prevent cells (BCCs) extravasation, among PI3K, HSP90, EGFR inhibitors approved drugs. used BCCs (4T1) BBB endothelial (b.End5) identify molecules with toxicity 4T1 safe b.End5 cells. Moreover, we those in mixed cultures perform...
Triple-negative breast cancer (TNBC) is a devastating BC subtype. Its aggressiveness, allied to the lack of well-defined molecular targets, usually culminates in appearance metastases that account for poor prognosis, particularly when they develop brain. Nevertheless, TNBC has been associated with epidermal growth factor receptor (EGFR) overexpression, leading downstream phosphoinositide 3-kinase (PI3K) signaling activation. We aimed unravel novel drug candidates treatment based on EGFR...
Abstract Background Venous thromboembolism (VTE) is one of the leading causes death in patients with cancer. Currently, there a need to develop an easily applicable risk model that can identify who will benefit from receiving primary thromboprophylaxis reduce incidence VTE. Patients and methods This was non-interventional, multicenter, observational, prospective study carried out 62 Oncology Hematology services Spain Portugal between January 2018 December 2019. The main objective CARTAGO...
Hemangiomas are usually diagnosed based on ultrasound findings. The presence of symptoms, rapid growth or atipical imagiological findings should make us consider other diagnoses, including malignant tumors such as angiosarcomas. We describe the case a previously healthy 46-year-old female without history exposure to carcinogens who presented with abdominal pain for two months. Diagnostic work-up revealed elevated gamma-glutamyl transferase and lactate dehydrogenase levels. Abdominal...
Globally, breast cancer is the most frequently diagnosed malignancy and leading cause of oncological death in women. Metastatic disease at diagnosis (de novo stage IV cancer) will be identified about 5% patients. Treatment options vary based on several factors, namely whether tumour hormone receptor positive human epidermal growth factor 2 (HER2) overexpressed. Here, we report a case HER2 metastatic woman her late 30s, with remission for over 3 years under second-line treatment...
Background: Germline mutations in the high-penetrance susceptibility genes BRCA1 and BRCA2 are associated with inherited predisposition for breast ovarian cancer. Pattern of varies considerably among different populations, there groups high prevalence particular according to geographical area, as c.156_157insAlu rearrangement, a founder mutation Portuguese origin one most frequent described date. In this study we review clinical pathological characteristics patients Hereditary Breast Ovarian...
Background: Male Breast Cancer (MBC) represents 1% of all breast cancers, as well less than malignant neoplasm in male. Methods: Describe male population with cancer (BC) our institute from 2007 to 2017. Unicentric, retrospective and descriptive study inclusion individuals diagnosis invasive carcinoma. Data was obtained through clinical process review analyzed SPSS®. Results: There were included 66 cases carcinoma a median age at 66,5 years old, [24-88] an initial ECOG PS 0 73% (n = 48)....