A5070985639- Respiratory Support and Mechanisms
- Intensive Care Unit Cognitive Disorders
- Sepsis Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Cardiac Arrest and Resuscitation
- Long-Term Effects of COVID-19
- Mechanical Circulatory Support Devices
- Immune Response and Inflammation
- Bipolar Disorder and Treatment
- Nosocomial Infections in ICU
- Airway Management and Intubation Techniques
- Family and Patient Care in Intensive Care Units
- Antibiotic Resistance in Bacteria
- Adrenal Hormones and Disorders
- COVID-19 and healthcare impacts
- SARS-CoV-2 and COVID-19 Research
- Pneumonia and Respiratory Infections
- Antibiotics Pharmacokinetics and Efficacy
- Aortic Disease and Treatment Approaches
- Tracheal and airway disorders
- Inflammation biomarkers and pathways
- Neonatal Respiratory Health Research
- Schizophrenia research and treatment
- Congenital Heart Disease Studies
- Electrolyte and hormonal disorders
Instituto Cajal
2017-2025
Universidad de Alcalá
2011-2024
Instituto Ramón y Cajal de Investigación Sanitaria
2020-2024
Hospital Universitario Ramón y Cajal
1992-2024
Hospital Universitari Joan XXIII de Tarragona
2024
Consorci Sanitari de Terrassa
2024
Hospital de Basurto
2022-2023
Hospital Universitario La Paz
2021-2022
Biogipuzkoa Health Research Institute
2020
University of Iowa Hospitals and Clinics
2019
There is considerable variation in disease behavior among patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes 2019 (Covid-19). Genomewide association analysis may allow for identification of potential genetic factors involved development Covid-19.
The duration of spontaneous breathing trials before extubation has been set at 2 h in research studies, but the optimal is not known. We conducted a prospective, multicenter study involving 526 ventilator-supported patients considered ready for weaning, to compare clinical outcomes with target durations 30 and 120 min. Of 270 256 30- 120-min trial groups, respectively, 237 (87.8%) 216 (84.8%), completed without distress were extubated (p = 0.32); 32 (13.5%) 29 (13.4%), these required...
Objective To investigate the role of nitric oxide in regulation vascular tone patients with sepsis syndrome. Design Prospective, intervention study. Setting Tertiary care hospital. Patients Fifteen admitted to our medical intensive unit diagnosis syndrome by defined criteria. Interventions Eight received Nω-nitro-L-arginine was followed hypertension (mean blood pressure increased from 89 ± 8 a maximum 140 12 mm Hg) accompanied decrease cardiac index (from 3.51 0.39 minimum 2.65 0.21...
<h3>BACKGROUND:</h3> Low-tidal-volume ventilation may be associated with repetitive opening and closing of terminal airways. The use PEEP is intended to keep the alveoli open. No method adjusting optimal has shown superior or improve clinical outcomes. We conducted a pilot study evaluate effect setting an individualized level at highest compliance on oxygenation, multiple-organ-dysfunction, survival in subjects ARDS. <h3>METHODS:</h3> Subjects ARDS ventilated low tidal volumes limitation...
Abstract Introduction It has recently been proposed that B lymphocytes are involved in sepsis pathogenesis. The goal of this study is to investigate potential abnormalities a subset distribution and activation circulating patients with septic shock. Methods This observational prospective was conducted medical-surgical ICU. All shock were eligible for inclusion. B-cell phenotypes (CD19+CD69+, CD19+CD23+, CD19+CD5+, CD19+CD80, CD19+CD86+, CD19+CD40 CD19+CD95+) assessed by quantitative flow...
Objective To investigate whether increasing oxygen delivery (Do2) by hematocrit results in increases uptake (Vo2) septic patients with an abnormal Do2/Vo2 relationship. Design Prospective, randomized, interventional crossover study. Setting Tertiary care hospital. Patients A consecutive sample of 16 admitted to the intensive unit, who were diagnosed as having severe sepsis defined criteria and had a hemoglobin concentration of<10 g/dL. Interventions received, random order, infusion...
Objective To study the role of nitric oxide in hemodynamic changes sepsis. Design Prospective, randomized, controlled, intervention study. Subjects Twenty-five sheep randomized to four groups: Group A (n = 8, nonseptic sheep) received NG-nitro L-arginine (20 mg/kg iv) followed 15 mins later by (200 iv); group B 4, L-arginine; C 7, septic alone; D 6, iv). Interventions Sheep were anesthetized with pentobarbital, mechanically ventilated and monitored a pulmonary artery catheter, peripheral...
Randomized trials assessing the effect of systemic corticosteroids on chronic obstructive pulmonary disease (COPD) exacerbations excluded patients who were mechanically ventilated or admitted to intensive care unit (ICU). Critically ill constitute a population persons are prone develop complications that potentially associated with use (eg, infections, hyperglycemia, ICU-acquired paresis) could prolong duration mechanical ventilation and even increase mortality.A double-blind...
ABSTRACT Background Respiratory failure is a key feature of severe Covid-19 and critical driver mortality, but for reasons poorly defined affects less than 10% SARS-CoV-2 infected patients. Methods We included 1,980 patients with respiratory at seven centers in the Italian Spanish epicenters pandemic Europe (Milan, Monza, Madrid, San Sebastian Barcelona) genome-wide association analysis. After quality control exclusion population outliers, 835 1,255 population-derived controls from Italy,...
When patients with a tracheostomy tube reach stage in their care at which decannulation appears to be possible, it is common practice cap the for 24 hours see whether they can breathe on own. Whether this approach establishing patient readiness leads better outcomes than one based frequency of airway suctioning unclear.In five intensive units (ICUs), we enrolled conscious, critically ill adults who had tube; were eligible after weaning from mechanical ventilation. In unblinded trial,...
Abstract Objectives Ceftazidime/avibactam and cefiderocol are two of the latest antibiotics with activity against a wide variety Gram-negatives, including carbapenem-resistant Enterobacterales. We sought to describe phenotypic genotypic characteristics ceftazidime/avibactam- cefiderocol-resistant KPC-Klebsiella pneumoniae (KPC-Kp) detected during an outbreak in 2020 medical ICU our hospital. Methods collected 11 KPC-Kp isolates (6 clinical; 5 surveillance samples) resistant...
Background: Procalcitonin is released in response to bacterial infection and it not Inflammatory viral diseases. Objective: To show the diagnostic efficacy prognostic value of procalcitonin for sepsis. Methods: A consecutive series 103 patients with suspected sepsis were admitted intensive care unit over a 2-year period. During first 24 hours admission procalcitonin, C-reactive protein, complement proteins determined. The was tested predictive values, likelihood ratios, receiver operating...
Given the pivotal role of T lymphocytes in immune system, patients with septic shock may show cell abnormalities. We have characterised compartment and assess its clinical implications. from peripheral blood 52 36 healthy control subjects were analysed on admission to intensive care unit, baseline, 3, 7, 14 28 days later. phenotypes (CD3+CD4+/CD3+CD8+, CD45RA+/CD45RO+, CD62L+/CD28+) assessed by quantitative flow cytometry. CD3+, CD3+CD4+ CD3+CD8+ lymphocyte counts significantly lower than...
Objectives To evaluate functional status and quality of life in elderly intensive care unit ( ICU ) survivors at 1‐year follow‐up. Design Prospective 18‐month observational study. Setting University medical–surgical . Participants aged 75 older. Measurements Functional baseline (Barthel Index BI )) was compared with that hospital discharge Health‐related HRQL Spanish version the Medical Outcomes Study 36‐item Short‐From Survey) measured follow‐up population same age. Results Of 176...
ABSTRACT Serratia marcescens is an opportunistic pathogen historically associated with sudden outbreaks in intensive care units (ICUs) and the spread of carbapenem-resistant genes. However, ecology S. populations hospital ecosystem remains largely unknown. We combined epidemiological information 1,432 spp. isolates collected from sinks a large ICU that underwent demographic operational changes (2019–2021) 99 non-redundant outbreak/non-outbreak same (2003–2019) 165 genomic data. These genomes...
Mortality in patients with septic shock remains unacceptably high and the attempts to antagonize certain proinflammatory cytokines based on results of animal model studies have failed improve survival rates. The objective this article is examine pro-/anti-inflammatory cytokine balance its connection mortality.Serum levels (tumor necrosis factor-α [TNF-α], interleukin 1β [IL-1β], interferonγ [IFN-γ], IL-6) soluble antagonists (soluble TNF receptor I [sTNF-RI], sTNF-RII, IL-1Ra) were...
The exact role of viral replication in patients with severe COVID-19 has not been extensively studied, and it only possible to demonstrate the presence replicative virus for more than 3 months a few cases using different techniques. Our objective was study RNA SARS-CoV-2 autopsy samples who died from long after onset symptoms. Secondary superimposed pulmonary infections present these were also studied. We an series 27 disease duration, where extrapulmonary obtained. In addition...
Abstract Purpose To assess the incidence and clinical impact of CMV infection in critically ill COVID-19 patients, examining ICU hospital mortality, length stay. Methods In this single-center, prospective observational study (March 2020 - September 2022), 431 patients with pneumonia moderate to severe ARDS were included. An active surveillance protocol was implemented, analyzing DNA plasma bronchoalveolar lavage (BAL). Clinical characteristics outcomes compared between CMV-COVID co-infected...