A5082061601- Venous Thromboembolism Diagnosis and Management
- Blood Coagulation and Thrombosis Mechanisms
- Hemophilia Treatment and Research
- Atrial Fibrillation Management and Outcomes
- Platelet Disorders and Treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac Imaging and Diagnostics
- Acute Myocardial Infarction Research
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Blood properties and coagulation
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- Systemic Lupus Erythematosus Research
- Trauma and Emergency Care Studies
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Blood groups and transfusion
- Heparin-Induced Thrombocytopenia and Thrombosis
- COVID-19 Clinical Research Studies
- Chemotherapy-induced cardiotoxicity and mitigation
- Cardiovascular Function and Risk Factors
- Sepsis Diagnosis and Treatment
- Protease and Inhibitor Mechanisms
- Renal Diseases and Glomerulopathies
- Heart Failure Treatment and Management
- Mosquito-borne diseases and control
Hospital General Universitario de Alicante Doctor Balmis
2016-2025
Instituto de investigación sanitaria y biomédica de Alicante
2022-2024
Universitat de Miguel Hernández d'Elx
2007-2024
Biomedical Research Institute
2021
Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana
2019
Hospital Universitari i Politècnic La Fe
2018
Banc de Sang i Teixits
2018
Vall d'Hebron Institut de Recerca
2018
Universitat Autònoma de Barcelona
2018
Sociedad Española de Cardiología
2017
Please cite this paper as: Tengborn L, Baudo F, Huth‐Kühne A, Knoebl P, Lévesque H, Marco Pellegrini Nemes Collins P on behalf of the EACH2 registry contributors. Pregnancy‐associated acquired haemophilia A: results from European Acquired Haemophilia (EACH2) registry. BJOG 2012;119:1529–1537. Objective The collected data demographics, diagnosis, underlying disorders, bleeding characteristics, treatment, and outcome women with A (AHA), a rare often severe disorder caused by autoantibodies...
Summary Treatment adherence in adolescents with chronic diseases is around 50%, and failure more common preventive therapy. In haemophilia, contradictory results are reported by the published studies. The objective of this study was to evaluate factor VIII (FVIII) prophylaxis Spanish patients severe haemophilia A between age 6 20 years. Data were collected retrosp‐ectively previous 2 primary endpoint absolute index (AAI), endpoints related clinical status, age, regimen, responsibility for...
Thrombotic Antiphospholipid Syndrome (TAPS) is an autoimmune disorder associated with a high risk of recurrent thromboembolic events. Despite advances in anticoagulation, predicting recurrence remains challenging, underscoring the need for more precise stratification to optimize personalized treatment. Traditional predictive models struggle integrate complexity clinical and biochemical factors, creating opportunity Machine Learning (ML) enhance prognostic accuracy. In this study, we...
We aimed to determine the predictive accuracy of elevated soluble thrombomodulin (sTM) and angiopoietin-2 (Ang2) for thrombotic events (TE) in hospitalized COVID-19 patients. conducted a nested case-control study within cohort people admitted hospital with from March 2020 August 2022. The cases (people TE 28 days after admission) were matched by propensity score comparable patients without TE. determined plasma levels sTM Ang2 all available frozen samples, prioritizing earliest...
Decreased matrix metalloproteinase-1 (MMP-1) and increased levels of its inhibitor, tissue inhibitor (TIMP-1), reflect impaired degradation with an increase in fibrosis. A prothrombotic state has been described atrial fibrillation (AF), increasing the risk stroke thromboembolism. Because structural abnormalities remodeling atria have observed AF, we hypothesized that AF may be related to abnormal indexes degradation.We studied 48 consecutive patients (30 men; age, 70.5+/-9.0 years) chronic...
Molecular diagnosis of patients with von Willebrand disease is pending in most populations due to the complexity and high cost conventional molecular analyses. The need for clinical characterization Spain prompted creation a multicenter project (PCM-EVW-ES) that resulted largest prospective cohort study all types disease. analysis relevant regions VWF, including intronic promoter regions, was achieved 556 individuals recruited via development simple, innovative, relatively low-cost protocol...
The diagnosis of von Willebrand disease (VWD) remains difficult in a significant proportion patients. A Spanish multicentre study investigated cohort 556 patients from 330 families who were analysed centrally. VWD was confirmed 480. Next generation sequencing (NGS) the whole coding VWF carried out all recruited patients, compared with phenotype, and final established. total 238 different mutations found, 154 not included Leiden Open Variation Database (LOVD). Of 463 found to have mutation/s....
The Spanish Acquired Hemophilia A (AHA) Registry is intended to update the status of AHA in Spain. One hundred and fifty-four patients were included retrospectively followed for a median 12 months. Patients predominantly male (56.3%), with age at diagnosis 74 years. was more frequently idiopathic (44.1%) autoimmune disorder-associated (31.7%). Thirty-four percent on antithrombotic therapy diagnosis. Hemostatic treatment used 70% patients. Recombinant activated factor VII infused (60.3% vs...