A5005407696- Venous Thromboembolism Diagnosis and Management
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Lung Cancer Diagnosis and Treatment
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Lung Cancer Treatments and Mutations
- Central Venous Catheters and Hemodialysis
- Cancer Treatment and Pharmacology
- Pleural and Pulmonary Diseases
- Lymphoma Diagnosis and Treatment
- RNA modifications and cancer
- Tracheal and airway disorders
- Colorectal Cancer Treatments and Studies
- Neuroendocrine Tumor Research Advances
- Occupational and environmental lung diseases
- Cancer Research and Treatments
- Sympathectomy and Hyperhidrosis Treatments
- Medical Imaging and Pathology Studies
- Gastric Cancer Management and Outcomes
- Pulmonary Hypertension Research and Treatments
- Cardiac tumors and thrombi
- Neonatal Respiratory Health Research
- Chronic Lymphocytic Leukemia Research
Bellvitge University Hospital
2015-2024
Hospital Universitario de Toledo
2023-2024
Complejo Hospitalario Universitario de Toledo
2023-2024
Institut d'Investigació Biomédica de Bellvitge
2012-2023
Hospital General Universitario de Ciudad Real
2018-2023
Hospital San Pedro de Alcántara
2016-2022
Universitat de Barcelona
2009-2022
Universitat Oberta de Catalunya
2022
Hospital Universitario Virgen de las Nieves
2021
Clinica Universidad de Navarra
2021
Pirfenidone, a pleiotropic anti-fibrotic treatment, has been shown to slow down disease progression of idiopathic pulmonary fibrosis (IPF), fatal and devastating lung disease. Rapamycin, an inhibitor fibroblast proliferation could be potential drug improve the effects pirfenidone. Primary fibroblasts from IPF patients human alveolar epithelial cells (A549) were treated in vitro with pirfenidone rapamycin presence or absence transforming growth factor β1 (TGF−β). Extracellular matrix protein...
Abstract Background Idiopathic pulmonary fibrosis (IPF) is a progressive parenchymal lung disease of unknown aetiology and poor prognosis, characterized by altered tissue repair fibrosis. The extracellular matrix (ECM) critical component in regulating cellular homeostasis appropriate wound healing. aim our study was to determine the expression profile highlighted ECM proteins IPF lungs. Methods gene protein analyzed cDNA microarrays, rt-PCR, immunohistochemistry western-blot lungs from...
Abstract Purpose: The microRNA-34b/c (miR-34b/c) is considered a tumor suppressor in different types and transcriptional target of TP53. main objectives this study were to investigate the clinical implications miR-34b/c methylation patients with early-stage lung adenocarcinoma determine functional role re-expression cell lines. Experimental Design: Aberrant expression assessed 15 lines cohort 140 adenocarcinoma. Lung transfected effects upon proliferation, migration, invasion, apoptosis...
The abnormal epithelial-mesenchymal restorative capacity in idiopathic pulmonary fibrosis (IPF) has been recently associated with an accelerated aging process as a key point for the altered wound healing. advanced glycation end-products (AGEs) are consequence of non-enzymatic reactions between lipid and protein several oxidants process. receptor AGEs (RAGEs) implicated lung fibrotic alveolar homeostasis. However, this AGE-RAGE pathway under-explored IPF. Lung samples from 16 IPF 9 control...
Abstract In 2011, the Spanish Society of Medical Oncology (SEOM) first published a clinical guideline venous thromboembolism (VTE) and cancer. This was updated in 2014, since then, multiple studies trials have changed landscape treatment prophylaxis VTE cancer patients. To incorporate most recent evidence, including data from direct oral anticoagulants (DOACs) randomized trials, SEOM presents new update guideline.
There is growing interest in the development of cell culture assays that enable rigidity extracellular matrix to be increased. A promising approach based on three-dimensional collagen type I matrices are stiffened by cross-linking through non-enzymatic glycation with reducing sugars. The present study evaluated biomechanical changes non-enzymatically glycated matrices, including organization, advanced end products formation and stiffness achievement. Gels were ribose at different...
BackgroundThe ever-growing complexity of cancer-associated thrombosis (CAT), with new antineoplastic drugs and anticoagulants, distinctive characteristics, decisions low levels evidence, justifies this registry.MethodTESEO is a prospective registry promoted by the Spanish Society Medical Oncology to which 34 centers contribute cases. It seeks provide an epidemiological description CAT in Spain.ResultsParticipants (N=939) diagnosed between July 2018 December 2019 were recruited. Most subjects...
Robotic-assisted thoracic surgery (RATS) is used increasingly frequently in major lung resection for early stage non-small-cell cancer (NSCLC) but has not yet been fully evaluated. The aim of this study was to compare the surgical outcomes lymph node dissection (LND) performed via RATS with those from totally thoracoscopic (TT) four-port videothoracoscopy. Clinical and pathological data were collected retrospectively patients clinical N0 NSCLC who underwent pulmonary form lobectomy or...
Although there is published research on the impact of venous thromboembolism (VTE) quality life (QoL), this issue has not been thoroughly investigated in patients with cancer—particularly using specific questionnaires. We aimed to examine acute symptomatic VTE QoL malignancies. This was a multicenter, prospective, case-control study conducted cancer either (cases) or without (controls) VTE. Participants completed EORTC QLQ-C30, EQ-5D-3L, PEmb-QoL, and VEINES-QOL/Sym Statistically significant...
Abstract Anaemia is defined by the presence of haemoglobin (Hb) levels < 13 g/dL in men and 12 women. Up to 39% cancer patients present it at time diagnosis up 40% have iron deficiency. causes fatigue, functional deterioration a reduction quality life; has also been associated with poorer response anti-tumour treatment lower survival. Basic diagnostic tests for anaemia are simple should be routine part clinical practice. These guidelines review available evidence on use different...
Background Chronic Obstructive Pulmonary Disease (COPD) is associated with subclinical systemic atherosclerosis and pulmonary vascular remodelling characterized by intimal hyperplasia luminal narrowing. We aimed to determine differences in the thickening of arteries COPD subjects smokers. Secondary aims include comparisons a non-smokers group; determining clinical variables thickening, correlations between changes. Methods All consecutive undergoing lung resection were included divided into...
Malignant pleural mesothelioma (MPM) is a rare and aggressive neoplasia affecting the lung mesothelium. Immune checkpoint inhibitors (ICI) in MPM have not been extremely successful, likely due to poor identification of suitable candidate patients for therapy. We aimed identify cellular immune fractions associated with clinical outcome classify based on their contexture. For each defined group, we sought molecular specificities that could help further define our classification at genomic...
Pancreatic carcinoma is one of the tumors associated with a higher risk for thromboembolic events, incidence rates ranging from 5% to 41% in previous retrospective series.We conducted study eleven Spanish hospitals that included 666 patients diagnosed pancreatic (any stage) between 2008 and 2011 treated chemotherapy. The main objective was evaluate venous events (VTE) this population, as well potential factors thrombosis. impact VTE on mortality also assessed.With median follow-up 9.3...
Abstract Background The aim of this study was to assess the effect lymphocyte-to-monocyte ratio (LMR), neutrophil-to-lymphocyte and platelet-to-lymphocyte on overall survival disease-free in patients with lung cancer treated radical surgery. Methods We performed a retrospective review who prospectively underwent resection between 2004 2012. Blood samples were taken as part preoperative workup. inflammatory markers studied absolute values lymphocytes, monocytes, neutrophils platelets,...