A5038028972- Sarcoma Diagnosis and Treatment
- Vascular Tumors and Angiosarcomas
- Pancreatic and Hepatic Oncology Research
- Cancer and Skin Lesions
- Salivary Gland Tumors Diagnosis and Treatment
- Bladder and Urothelial Cancer Treatments
- Cancer Immunotherapy and Biomarkers
- Cardiac tumors and thrombi
- Soft tissue tumor case studies
- Breast Lesions and Carcinomas
- Gastric Cancer Management and Outcomes
- Pharmaceutical Practices and Patient Outcomes
- Neuroblastoma Research and Treatments
- Urinary and Genital Oncology Studies
- Neuroendocrine Tumor Research Advances
- Bone Tumor Diagnosis and Treatments
- Tumors and Oncological Cases
- Metastasis and carcinoma case studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Urologic and reproductive health conditions
- Adrenal and Paraganglionic Tumors
- Cancer Diagnosis and Treatment
- Viral-associated cancers and disorders
- HER2/EGFR in Cancer Research
- Cancer-related molecular mechanisms research
Rajiv Gandhi Cancer Institute and Research Centre
2017-2025
Vignan's Foundation for Science, Technology & Research
2024
Amrita Institute of Medical Sciences and Research Centre
2023
Maulana Azad Medical College
2011-2012
This research explores innovative approaches to enhance energy efficiency in cloud computing by automating the deployment of simulated hardware, tailoring resource allocation individual user needs. Emphasizing dynamic nature load demands, study leverages adaptability technology for efficient Virtual Machine (VM) migrations, particularly within edge environments. Unlike traditional data centers, clouds present challenges due limited resources. The investigation centers on optimizing bandwidth...
Eosinophilic solid and cystic renal cell carcinoma (ESCRCC) is an under-recognized, emerging new entity of sporadic neoplasms, with approximate incidence 0.2% tumors. A total 60 cases have been reported in the literature till date. ESCRCC are usually seen adult females, a low stage indolent behavior, rare recurrence or metastasis. They tumors variably sized cysts resembling eosinophilic RCC, showing characteristic positive immune-expression for PAX-8, CK20 (in ~80% cases) and/or Melan–A...
Pseudomyogenic hemangioendothelioma (PMH) is a rare tumor of vascular origin with intermediate malignant potential which commonly presents as subcutaneous and soft-tissue mass or without concurrent bone involvement. However, PMH presenting primary multifocal lesions rare. Histomorphologically, it mimicks other epithelioid tumors cytokeratin expression in can prompt an erroneous diagnosis metastatic carcinoma, especially elderly patient. Diligent histopathological examination judicious...
Giant cell tumor of bone (GCTB) is a benign neoplasm, which can sometimes be diagnostic challenge, especially in small biopsies, due to its histologic and malignant mimics. We evaluated the role H3.3 G34W immunohistochemistry (IHC) antibody diagnosing GCTB differentiating it from close A total 120 cases (80 40 mimics) were retrieved subjected IHC. Of 80 GCTB, 72 showed positive nuclear immunoexpression, while all mimics negative staining for Sensitivity specificity this mutation-specific...
Male breast cancers (MBCs) are uncommon and account for 1% of all cancers. Medical conditions that increase the estrogen to testosterone ratio implicated as risk factors. Morphologically similar, but MBCs have biological differences compared with female cancer (FBC).The present study was aimed examine immunophenotype MBC, subsequent molecular subtypes, their association clinicopathological features, prognosis.We analyzed features 42 cases classified them according classification using...
The ASCO/CAP guidelines for HER2 reporting in breast cancer published 2007 and were updated 2013 to assure that the right patient receives targeted therapy. have lowered threshold positivity criteria altered equivocal category both IHC FISH. This first study from India addresses impact of these various categories at a tertiary care centre. We compared trend 1 year before (Period A) after B) implementation guidelines. All cases post reclassified as per detect additional number been put into...
Human epidermal growth factor receptor 2 (HER-2) is an established prognostic and predictive biomarker for breast cancer. To ensure accuracy uniformity HER-2 testing, ASCO/CAP published guidelines in 2007 which were updated 2013 recently 2018. In this first study from Indian Oncology center, we evaluated the impact of 2018 guidelines. We found a substantial decrease equivocal IHC cases (P-value < .00001). On reclassification, total 5.6% positive categories (2013 guidelines) shifted to...
Hepatoid adenocarcinoma of lung is a rare entity, accounting for 5% all hepatoid adenocarcinoma. Distinguishing it from metastatic hepatocellular carcinoma essential, but occasionally can be very challenging, especially with concurrent liver mass. A judicious immunohistochemical panel warranted accurate diagnosis and subsequent preservation tissue molecular testing. There limited data on the mutational status, behavior management strategies this type We report largest series six cases citing...
Ewing sarcoma (ES) are malignant small round cell tumors (MSRCT) characterized by rearrangements of EWSR1 gene. Although gold standard for diagnosis is detection specific fusion genes molecular testing, these ancillary tests costly and only available in limited number settings. There a persuasive evidence reliability NKX2.2 immunohistochemistry (IHC) as surrogate marker gene rearrangement ES.The aim this study to correlate the immuno-expression with genetically confirmed ES cases also assess...
Epithelioid hemangioma of bone is a rare and locally aggressive vascular neoplasm associated with good prognosis. Because its worrisome histomorphologic features clinicoradiologic findings, at times multifocal presentation, they tend to simulate malignant tumors. We report series four cases epithelioid their clinicopathologic characteristics. All had adjacent soft tissue involvement two disease. Microscopically, all tumor in lobular configuration, composed endothelial cells the formation...
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare, aggressive classified under acute myeloid leukemia (AML) and related precursor by current WHO classification. Elderly male are commonly affected with cutaneous lesion being the hallmark of disease presentation. The progresses rapidly sooner or later involves bone marrow peripheral blood. Cases presenting primarily as without involvement rarity about 29 cases reported in literature till date. Characteristic immunophenotype CD4...
Persistent hyperinsulinemic hypoglycaemia is caused most commonly by an insulinoma in adults or nesidioblastosis neonates. In adults, localised islet cell hyperplasia a rare disorder characterised proliferation of cells. The authors present the case previously healthy non-obese middle aged female with new-onset severe hypoglycaemia. Laboratory findings confirmed Endoscopic ultrasonography, intra-arterial calcium stimulation test and intraoperative ultrasonography showed lesion uncinate...
Renal cell carcinoma (RCC) accounts for 2% of all cancer cases worldwide, and majority are sporadic. The latest World Health Organization (WHO) classification renal tumors (fifth edition, 2022) has molecularly defined tumor entities, which includes fumarate hydratase (FH)–deficient RCC. FH‐deficient RCC is an aggressive caused by pathogenic alterations in FH gene, seen 15% patients with hereditary leiomyomatosis syndrome (HLRCC) syndrome. These occur more frequently at a younger age present...
Solitary fibrous tumor of the central nervous system (CNS) accounts for <1% all primary CNS tumors. These tumors are typically dura‑based and graded using a three‑tiered based on cellularity, mitotic activity necrosis. Extracranial metastasis this disease is rare. The present study reports 3 cases rare tumor, retrieved from hospital archives over period 5 years. hematoxylin eosin‑stained immunohistochemistry (IHC) slides were reviewed by two pathologists clinical details obtained records....
<title>Abstract</title> <bold>Background:</bold>Synovial sarcoma usually presents with spindle cell morphology or without epithelial differentiation. Extensive rhabdoid differentiation is a very rare feature only few cases has been described in literature. <bold>Case Presentation:</bold> We present two of synovial along their clinical follow-up. Both had tumor the vicinity joints and showed lung metastasis during follow-up inspite R0 resection. emphasised that extensive can be deceptive...