A5086687064- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Bladder and Urothelial Cancer Treatments
- Radiopharmaceutical Chemistry and Applications
- Urological Disorders and Treatments
- Urinary and Genital Oncology Studies
- Cancer, Lipids, and Metabolism
- Hormonal and reproductive studies
- PARP inhibition in cancer therapy
- Cancer Diagnosis and Treatment
- Cancer survivorship and care
- Renal cell carcinoma treatment
- Telemedicine and Telehealth Implementation
- Renal and related cancers
- Health Systems, Economic Evaluations, Quality of Life
- Clinical practice guidelines implementation
- Testicular diseases and treatments
- Sarcoma Diagnosis and Treatment
- Palliative Care and End-of-Life Issues
- Multiple Myeloma Research and Treatments
- Cancer Treatment and Pharmacology
- Genital Health and Disease
- Advanced Breast Cancer Therapies
- Delphi Technique in Research
- Inflammatory Biomarkers in Disease Prognosis
University of Calgary
2016-2025
Prostate Cancer Canada
2022
Calgary Laboratory Services
2022
Memorial Sloan Kettering Cancer Center
2010-2015
University of British Columbia
2001-2013
New York Proton Center
2010-2011
Montefiore Medical Center
2010
St. Paul's Hospital
2007
London Health Sciences Centre
2006
Patients with prostate cancer who have high-risk biochemical recurrence an increased risk of progression. The efficacy and safety enzalutamide plus androgen-deprivation therapy monotherapy, as compared alone, are unknown. Download a PDF the Research Summary. In this phase 3 trial, we enrolled patients had prostate-specific antigen doubling time 9 months or less. were randomly assigned, in 1:1:1 ratio, to receive (160 mg) daily leuprolide every 12 weeks (combination group), placebo...
Salvage radical prostatectomy is associated with a higher complication rate than without prior radiotherapy but the magnitude of increase not well delineated.A total 3,458 consecutive patients underwent open and 98 salvage from January 1999 to June 2007. Data were collected prospective surgical institutional morbidity databases, retrospectively billing records medical records. Medical complications captured, graded by modified Clavien classification classified time onset.Median followup...
SifA was originally identified as a virulence factor required for formation of Salmonella-induced filaments (Sifs), elongated tubules rich in lysosomal glycoproteins that extend from the Salmonella-containing vacuole infected epithelial cells. Here, we demonstrate deletion mutants ssaR, component SPI-2 type III secretion system, do not form Sifs HeLa This suggests is translocated effector this acting within host cells to Sifs. In support hypothesis, transfection with vector encoding fused...
Objectives: Lymphocele is the most common complication of pelvic lymphadenectomy (PLND). We sought to determine predictors symptomatic lymphocele after radical prostatectomy (RP) and PLND, in particular, if number drains placed represents an independent predictor. Methods: Between January 1999 June 2007, 4173 consecutive patients underwent bilateral PLND at time either open or laparoscopic RP. Lymphoceles were identified undergoing imaging as a result symptoms suspicious for lymphocele, such...
Aims To evaluate concordance, upgrades and downgrades from biopsy to prostatectomy, associated clincopathological parameters, using the recently proposed Gleason grade groups/International Society of Urologic Pathology ( ISUP ) grades. Methods results We evaluated 2529 patients who underwent prostatectomy in our institution 2005 2014. A global group GR )/Gleason score GS was used. Factors with 1/ ≤6 2/ 3 + 4 were analysed by multivariable logistic regression. The final / identical 59.3%...
This initiative was undertaken in response to concerns regarding the variation management and outcomes of patients with bladder cancer throughout centres geographical areas Canada. Population-based data have also revealed that real-life survival is lower than expected based on from clinical trials and/or academic centres. To address these perceived shortcomings attempt streamline unify treatment approaches Canada, a multidisciplinary panel expert clinicians convened last fall for two-day...
147 Background: LIBERTAS is investigating APA in combination with intermittent ADT as an de-escalation strategy for patients mCSPC. The objective to evaluate whether + pts who achieved PSA <0.2 ng/mL after 6 mo initial treatment provides noninferior radiographic progression-free survival (rPFS) and reduces hot flash burden compared continuous ADT. In the TITAN study, 54% (263/490) of mCSPC treated ≤0.2 within 3 (1). Pts also ≤0.02 vs >0.2 showed better overall rates (2). Here, we...
353 Background: Patients (pts) with localized high-risk/very high-risk prostate cancer (PCa) have an elevated risk of metastases and Prostate Cancer (PC)-specific death following local therapy. This is significantly higher for patients a persistently PSA (pPSA) after Radical Prostatectomy (RP) We aim to better understand the current management strategies this population using real world data. Methods: performed retrospective population-based cohort study province-wide linked administrative...
349 Background: Patients diagnosed with high- or very high risk (H/vHR) prostate cancer (PCa) are at substantial of disease recurrence, metastasis, and death after treatment. Historically, treatment paradigms for these patients have been similar to those intermediate-risk (IR) [radiotherapy (RT) androgen deprivation therapy (ADT) radical prostatectomy (RP)] though there is a growing body evidence supporting intensified systemic in this group. To contextualize emerging trial data, we...
We reviewed our experience with the Dornier Doli S lithotriptor to address 2 questions. 1) What is stone-free rate? 2) Can a outcome be predicted by preoperative computerized tomography?The records of 76 consecutive patients undergoing shock wave lithotripsy for solitary urinary calculi 5 20 mm in diameter were studied retrospectively. Pretreatment noncontrast tomography was determine Hounsfield density. The determined at 12 weeks on imaging and categorized as stone free, any residual...
Anastomotic strictures are relatively common after radical prostatectomy and associated with significant morbidity, often requiring multiple surgical interventions. There is controversy in the literature regarding which factors predict development of anastomotic strictures. In this study we determined predictors symptomatic following contemporary prostatectomy.Between 1999 2007, 4,592 consecutive patients underwent without prior radiotherapy at our institution. Data were collected from...
To assess the understanding of patients, who had previously undergone radical prostatectomy (RP), about their postoperative sexual function, as clinical experience suggests that some RP patients have unrealistic expectations long-term function.Patients presenting within 3 months open or robot-assisted laparoscopic (RALP) were questioned function information they received preoperatively. Patients erectile (EF), ejaculatory status, orgasm, and penile morphology changes. Statistical analyses...
The practice of assigning “case level” biopsy Grade Group (GG) or Gleason Score is variable. To our knowledge, a comparison the concordance different GG with prostatectomy has not been done in post-2005 prostate cancer cohort. We evaluated 2527 patients who had and radical performed at institution between 2005 2014. compared agreements, upgrades, downgrades 3 GG, final GG: (1) Global (sum most prevalent highest grade any part/site-specific specimen); (2) Highest (found (3) Largest Volume...
No AccessJournal of UrologyAdult Urology1 Jan 2011Prognostic Impact Muscular Venous Branch Invasion in Localized Renal Cell Carcinoma Cases Andrew Feifer, Caroline Savage, Heidi Rayala, William Lowrance, Geoffrey Gotto, Preston Sprenkle, Amit Gupta, Jennifer Taylor, Melanie Bernstein, Adebowale Adeniran, Satish K. Tickoo, Victor E. Reuter, and Paul Russo FeiferAndrew Feifer More articles by this author , SavageCaroline Savage RayalaHeidi Rayala LowranceWilliam Lowrance GottoGeoffrey Gotto...
Management of advanced prostate cancer has evolved rapidly with the availability multiple systemic treatments such as androgen-receptor axis-targeted therapies (ARATs), taxane-based chemotherapy, radium-223, and other approaches. However, limited data exists on real-world treatment selection clinical outcomes. This study examines utilization survival impact these in men metastatic castration-resistant (mCRPC) setting Ontario, Canada. was a retrospective, longitudinal, population-based...
Testosterone suppression, achieved through orchiectomy or medically induced androgen-deprivation therapy (ADT), is a standard treatment for men with recurrent and metastatic prostate cancer. Current assay methods demonstrate the capacity testosterone suppression to <0.7 nmol/l, clinical data support improved outcomes from ADT when lower levels are achieved. Practical guidelines warranted facilitate adoption of 0.7 nmol/l as new castrate level. A pan-Canadian group experts, representing...