A5101789648- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Breast Cancer Treatment Studies
- Renal and related cancers
- Cancer Genomics and Diagnostics
- Renal cell carcinoma treatment
- Breast Lesions and Carcinomas
- Statistical Methods in Clinical Trials
- Global Cancer Incidence and Screening
- Advanced Radiotherapy Techniques
- Bone health and treatments
- Urologic and reproductive health conditions
- Molecular Biology Techniques and Applications
- Renal Diseases and Glomerulopathies
- Cancer Immunotherapy and Biomarkers
- Health Systems, Economic Evaluations, Quality of Life
- Radiopharmaceutical Chemistry and Applications
- Chronic Kidney Disease and Diabetes
- Hormonal Regulation and Hypertension
- Breast Implant and Reconstruction
- Patient-Provider Communication in Healthcare
- Radiomics and Machine Learning in Medical Imaging
- Renin-Angiotensin System Studies
- HER2/EGFR in Cancer Research
- Cancer Treatment and Pharmacology
Ottawa Hospital
2010-2023
University of Ottawa
2008-2023
Canadian Electricity Association
2019-2022
Ottawa Hospital Research Institute
2012
Ottawa Regional Cancer Foundation
2005
Validated biomarkers are needed to improve risk assessment and treatment decision-making for women with ductal carcinoma in situ (DCIS) of the breast. The Oncotype DX® DCIS Score (DS) was shown predict local recurrence (LR) individuals low-risk treated by breast-conserving surgery (BCS) alone. Our objective confirm these results a larger population-based cohort individuals. We used an established diagnosed BCS alone from 1994 2003 validation outcomes. Central pathology excluded cases...
ABSTRACT. Mutations in the gene encoding α-actinin-4 (ACTN4), an actin crosslinking protein, are associated with a form of autosomal dominant focal segmental glomerulosclerosis (FSGS). To better study its progression, transgenic mouse model was developed by expressing murine containing mutation analogous to that affecting human FSGS family podocyte-specific manner using nephrin promoter. Consistent ACTN4-associated FSGS, which shows incomplete penetrance, proportion mice exhibited...
Angiotensin-converting enzyme 2 (ACE2) is expressed at high levels in the kidney and converts angiotensin II (ANG II) to ANG-(1-7). We studied effects of ACE2 inhibition ANG-(1-7) (5/6) nephrectomy ((5/6) Nx) mouse model chronic disease (CKD). Male FVB mice underwent sham surgery (Sham) or Nx were administered either vehicle, inhibitor MLN-4760 (MLN), AT(1) receptor antagonist losartan, MLN plus for 4 wk. In with without MLN, cortical protein expression was significantly decreased wk,...
Abstract BACKGROUND: The objective of this study was to evaluate the predictive value prostate biopsies that were obtained 24 months after completion radiotherapy (RT) with respect disease‐free survival (DFS) in a randomized trial compared 3 versus 8 neoadjuvant hormone therapy before conventional dose external RT. METHODS: From February 1995 June 2001, 378 men receive either or combined flutamide and goserelin they received 66 Gray RT at 4 participating centers. By risk group, 26% patients...
The objective of this study was to correlate the failure pattern localized prostate carcinoma after radiotherapy (RT) with pretreatment (preTx) PSA and post-RT nadir PSA, using systematic biopsies serum in assessment outcome.From January 1990 February 1994, 207 patients treated external beam RT were followed prospectively transrectal ultrasound-guided measurements levels. Three hundred forty-three performed, 4-7 samples taken per session. distribution T classification as follows: 19 had T1b,...
Papillary renal cell carcinoma (PRCC) can display extensive areas of solid and non‐papillary architecture with oncocytic cytoplasm. Eleven neoplasms (ORCN) histopathological features posing a diagnostic problem between (RCC) oncocytoma (RO) were identified. The well circumscribed or encapsulated tumors diffuse growth pattern. Very occasional papillae seen in four tumoral necrosis two 11. Six ORCN displayed CD117+/progesterone receptor (PR)+ immunophenotype (feature shared by RO) five...
Background . The waiting period to surgery represents a valuable “window of opportunity” evaluate novel therapeutic strategies. Interventional studies performed during this require significant multidisciplinary collaboration overcome logistical hurdles. We undertook one-year prospective window opportunity study assess feasibility. Methods Eligible newly diagnosed postmenopausal, estrogen receptor positive breast cancer patients awaiting primary received anastrozole daily until surgery....
Bone-targeting agents (BTAs), such as bisphosphonates and denosumab, have demonstrated no discernable effects on tumour response or disease free/overall survival in patients with bone metastases from breast cancer. Doxycycline is both osteotropic has anti-cancer effects. When combined zoledronate animal models, doxycycline showed significantly increased inhibition of burden formation. We evaluated the adding to ongoing therapy metastatic Breast cancer ≥3 months BTA use, entered this...
Aims: To investigate the reactivity for oestrogen and progesterone receptors (ER PR) in renal oncocytoma (RO) chromophobe cell carcinoma (CHRCC). Materials methods: Thirty‐eight RO, 25 CHRCC, 20 papillary RCC with oncocytic cytoplasm 10 clear dominant eosinophilic were submitted immunohistochemistry ER, PR, CD117 RCC. Results: All cases of RO CHRCC displayed moderately positive PR. The nuclear ranged from 60% to 90% occasional cells 70% CHRCC. In tended be more prevalent areas tumour...