A5110191238- Breast Cancer Treatment Studies
- Breast Lesions and Carcinomas
- Global Cancer Incidence and Screening
- Lymphoma Diagnosis and Treatment
- Breast Implant and Reconstruction
- Colorectal and Anal Carcinomas
- Colorectal Cancer Surgical Treatments
- Chronic Lymphocytic Leukemia Research
- Sarcoma Diagnosis and Treatment
- Immunodeficiency and Autoimmune Disorders
- Cancer Immunotherapy and Biomarkers
- Hematopoietic Stem Cell Transplantation
- Cancer Genomics and Diagnostics
- MRI in cancer diagnosis
- CNS Lymphoma Diagnosis and Treatment
- Inflammasome and immune disorders
- Lung Cancer Diagnosis and Treatment
- Ultrasound and Hyperthermia Applications
- Mass Spectrometry Techniques and Applications
- Head and Neck Anomalies
- Cutaneous lymphoproliferative disorders research
- Genetic and rare skin diseases.
- BRCA gene mutations in cancer
- Vascular Tumors and Angiosarcomas
- Thyroid Cancer Diagnosis and Treatment
Northeast Cancer Centre
2021-2022
Allegheny General Hospital
2018-2021
Allegheny Health Network
2015-2021
Thunder Bay Regional Health Sciences Centre
2008-2017
University of Toronto
2006-2016
Health Sciences Centre
2011-2016
Sunnybrook Health Science Centre
2011-2016
Mount Sinai Hospital
2016
University of California, San Francisco
2016
NOSM University
2015-2016
Abstract: Inflammation is the body's response to insults, which include infection, trauma, and hypersensitivity. The inflammatory complex involves a variety of mechanisms defend against pathogens repair tissue. In lung, inflammation usually caused by or exposure toxins, pollutants, irritants, allergens. During inflammation, numerous types cells are activated. Each releases cytokines mediators modify activities other cells. Orchestration these molecules leads progression inflammation....
Validated biomarkers are needed to improve risk assessment and treatment decision-making for women with ductal carcinoma in situ (DCIS) of the breast. The Oncotype DX® DCIS Score (DS) was shown predict local recurrence (LR) individuals low-risk treated by breast-conserving surgery (BCS) alone. Our objective confirm these results a larger population-based cohort individuals. We used an established diagnosed BCS alone from 1994 2003 validation outcomes. Central pathology excluded cases...
Most women with ductal carcinoma in situ (DCIS) will receive breast-conserving surgery (BCS) and radiation (RT). RT can be omitted for at low risk of local recurrence (LR). The Oncotype DX DCIS score (DS) predicts LR after BCS alone. This study assesses the impact DS on risk.Population-based cohort analysis individuals treated by ± from 1994-2003. Treatment outcomes were determined linkage chart review. We used a propensity score-adjusted multivariable model to examine associations between...
The main goal of treating ductal carcinoma in situ (dcis) is to prevent the development invasive breast cancer. Most women are treated with breast-conserving surgery (bcs) and radiotherapy. Age at diagnosis may be a risk factor for recurrence, leading concerns that additional treatment necessary younger women. We report population-based study dcis bcs radiotherapy an evaluation effect age on local recurrence (lr).All diagnosed Ontario from 1994 2003 were identified. Treatments outcomes...
Mastectomy is effective treatment for ductal carcinoma in situ (DCIS) but some women will develop chest wall recurrence. Most recurrences that after mastectomy are invasive cancer and associated with poorer prognosis. Past studies have been unable to identify factors predictive of Therefore, it remains unclear if a subset exists DCIS treated by experience high rate recurrence whom more aggressive may be benefit. We report outcomes all Ontario (N = 1,546) diagnosed pure from 1994 2003 without...
Background: In locally advanced rectal cancer treatment, neoadjuvant concurrent chemoradiation therapy (cCRT) is the standard of care. The tumor microenvironment (TME) a complex entity comprising cells, immune cells and surrounding stroma closely associated with growth survival, response to antitumor therapies also resistance treatment. We aimed assess change in biomarkers TME following cCRT cancer. Methods: accessed archival tissue from patients treated at Allegheny Health Network (AHN)...
Abstract By multiparameter flow cytometry, the T‐cell‐associated markers CD4 and CD7 were aberrantly coexpressed on a case of B‐cell chronic lymphocytic leukemia (CLL). The CLL had an immunophenotype: CD19+, CD20+, CD79b+, CD5+, CD23+, FMC7+, kappa+, CD4+, CD7+. Molecular analysis confirmed clonal rearrangement immunoglobin heavy chain genes germline configuration T‐cell receptor genes. Fluorescence in situ hybridization showed trisomy 12 anomaly. There was no evidence deletion 17p (p53),...
Abstract Background: DCIS patients need better tools to align the aggressiveness of treatment with their disease. The Score (DS) was validated as a predictor ipsilateral breast recurrence (IBR; or invasive) in 327 E5194 treated by breast-conserving surgery (BCS) without radiation (RT) (Solin,2013). This Ontario population based study 3335 women from 1994 2003 (Rakovitch,2013) conducted test risk BCS alone and BCS+RT. Methods: REMARK guidelines were followed. Breast pathologists centrally...
We characterized in vivo a functional superparamagnetic iron-oxide magnetic resonance contrast agent that shortens the <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:msub><mml:mrow><mml:mi>T</mml:mi></mml:mrow><mml:mrow><mml:mn fontstyle="italic">2</mml:mn></mml:mrow></mml:msub></mml:mrow></mml:math> relaxation time imaging (MRI) of prostate cancer xenografts. The was developed by conjugating Molday ION™ carboxyl-6 (MIC6), with deimmunized mouse monoclonal...
The D2-40 antigen is a glycosylated sialomucin that strongly expressed by lymphatic endothelial cells. Recently we observed the expression of on luminal surface pulmonary airspaces in lung sections. aim study was to assess normal development and various pathologic conditions which abnormal alveolar infiltrates were present. Formalin-fixed tissue selected from 42 fetal/neonatal autopsy cases ranging gestational age 12 41 weeks 10 adult lungs. In group, 22 histologically normal, whereas 20...
581 Background: In the Ontario population based study, DCIS Score was significantly associated with 10 year risk of an ipsilateral local recurrence (LR - in situ or invasive carcinoma) women treated breast conserving surgery (BCS) without radiation (RT) (P < 0.001). Here we evaluate correlation between and clinicopathologic (CP) features same cohort, whether provides independent information. Methods: The study included 571 diagnosed province from 1994 – 2003 prospectively selected for...