A5090123950- Traffic and Road Safety
- Palliative Care and End-of-Life Issues
- Breast Cancer Treatment Studies
- Injury Epidemiology and Prevention
- Cancer survivorship and care
- Global Cancer Incidence and Screening
- Health Systems, Economic Evaluations, Quality of Life
- Diabetes Treatment and Management
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Chronic Disease Management Strategies
- Emergency and Acute Care Studies
- Vaccine Coverage and Hesitancy
- Pregnancy-related medical research
- Diabetes Management and Education
- Childhood Cancer Survivors' Quality of Life
- Substance Abuse Treatment and Outcomes
- Suicide and Self-Harm Studies
- COVID-19 epidemiological studies
- Heart Failure Treatment and Management
- Older Adults Driving Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Breast Lesions and Carcinomas
- Trauma and Emergency Care Studies
- Bariatric Surgery and Outcomes
- Agriculture and Farm Safety
Institute for Clinical Evaluative Sciences
2015-2024
Sunnybrook Health Science Centre
2013-2023
Sunnybrook Research Institute
2012-2023
RELX Group (United States)
2023
Sunnybrook Hospital
2012-2021
University of Toronto
2006-2020
Health Sciences Centre
2006-2019
Massachusetts Department of Agricultural Resources
2018
Centre for Addiction and Mental Health
2016
Canadian Armed Forces
2016
In 2000, Ontario, Canada, initiated a universal influenza immunization program (UIIP) to provide free vaccines for the entire population aged 6 mo or older. Influenza increased more rapidly in younger age groups Ontario compared other Canadian provinces, which all maintained targeted programs. We evaluated effect of Ontario's UIIP on influenza-associated mortality, hospitalizations, emergency department (ED) use, and visits doctors' offices.
Tracheostomy is common in intensive care unit patients, but the appropriate timing controversial.To determine whether earlier tracheostomy associated with greater long-term survival.Retrospective cohort analysis.Acute hospitals Ontario, Canada (n = 114).All mechanically ventilated patients who received between April 1, 1992 and March 31, 2004, excluding extreme cases (< 2 or > 28 days) children 18 yrs).For crude analyses, was classified as early 10 vs. late (> mortality measured at multiple...
Self-harm behaviors, including suicidal ideation and past suicide attempts, are frequent in bariatric surgery candidates. It is unclear, however, whether these behaviors mitigated or aggravated by surgery.To compare the risk of self-harm before after surgery.In this population-based, self-matched, longitudinal cohort analysis, we studied 8815 adults from Ontario, Canada, who underwent between April 1, 2006, March 31, 2011. Follow-up for each patient was 3 years prior to surgery.Self-harm...
Physicians' warnings to patients who are potentially unfit drive a medical intervention intended prevent trauma from motor vehicle crashes. We assessed the association between and risk of subsequent road
Ductal carcinoma in situ (DCIS) is a non-invasive form of breast cancer that may progress to invasive cancer. Identification factors predict recurrence and distinguish DCIS from would facilitate treatment recommendations. We examined the prognostic value nine molecular markers on risks local (DCIS invasive) among women treated with breast-conserving therapy.A total 213 who were therapy between 1982 2000 included; 141 received surgery alone 72 cases radiotherapy. performed immunohistochemical...
<h3>Background:</h3> Head injuries have been associated with subsequent suicide among military personnel, but outcomes after a concussion in the community are uncertain. We assessed long-term risk of concussions occurring on weekends or weekdays community. <h3>Methods:</h3> performed longitudinal cohort analysis adults diagnosis Ontario, Canada, from Apr. 1, 1992, to Mar. 31, 2012 (a 20-yr period), excluding severe cases that resulted hospital admission. The primary outcome was weekend...
The Edmonton Symptom Assessment System (ESAS) is a validated instrument whose use has been standardized in the Ontario cancer system to measure symptoms among ambulatory patients. objective was examine effect of ESAS exposure on overall survival. We hypothesized, priori, that patients exposed would have higher rates survival than those who were not exposed.
The Edmonton Symptom Assessment System (ESAS) is a validated instrument whose use has been standardized in the Ontario cancer system to measure symptoms among ambulatory patients with cancer. objective was examine effect of ESAS exposure on visits emergency department (ED) and hospitalizations.This retrospective matched cohort study conducted Ontario, Canada. included ≥ 18 years age diagnosed between 2007 2015. Patients were considered exposed if they screened at least once during period,...
Intensive care unit (ICU) admission for bone marrow transplant recipients immediately following transplantation is an ominous event, yet the survival of these patients with subsequent ICU admissions unknown. Our objective was to determine long-term outcome admitted during hospitalizations.We conducted a population-based cohort analysis all adult who received in Ontario, Canada from 1 January 1992 31 March 2002. The primary endpoint mortality at year.A total 2,653 transplantation; 504 which...
Unplanned hospital readmission is a complex process, particularly if the patient readmitted to an acute care institution other than original hospital. This study tested hypothesis that alternative associated with increased mortality compared hospital.We performed population-based retrospective cohort analysis set between 1995 and 2010 for all 21 adult general hospitals in Greater Toronto Hamilton Area. Participants were consecutive adults (age ≥ 18 yr) through emergency department within 30...
The main goal of treating ductal carcinoma in situ (dcis) is to prevent the development invasive breast cancer. Most women are treated with breast-conserving surgery (bcs) and radiotherapy. Age at diagnosis may be a risk factor for recurrence, leading concerns that additional treatment necessary younger women. We report population-based study dcis bcs radiotherapy an evaluation effect age on local recurrence (lr).All diagnosed Ontario from 1994 2003 were identified. Treatments outcomes...
<h3>Importance</h3> Concussions are an acute injury that may lead to chronic disability, while statin use might improve neurologic recovery. <h3>Objective</h3> To test whether is associated with increased or decreased risk of subsequent dementia after a concussion. <h3>Design, Setting, and Participants</h3> Large extended population-based double cohort study in Ontario, Canada, from April 1, 1993, 2013 (enrollment), continued until March 31, 2016 (follow-up). Dates analysis were 28, 2014,...
<h3>Background:</h3> Gun injury accounts for substantial acute mortality worldwide and many others survive with lingering disabilities. We investigated whether additional health losses beyond can also arise patients who long-term disability. <h3>Methods:</h3> conducted a population-based individual patient analysis of adults injured by firearms had received emergency medical care in Ontario, Canada, from Apr. 1, 2002, to 2019. Longitudinal cohort analyses were evaluated through deterministic...
Background Patients with chronic obstructive pulmonary disease (COPD) are more likely to be readmitted than patients other medical conditions, yet knowledge regarding such readmissions is limited. We aimed determine factors associated readmission within 30 days of a COPD hospitalization or death an emphasis on examining aspects socioeconomic status and specific comorbidities. Methods A population-based cohort study was conducted using health administrative data from Ontario, Canada. All...
Objectives Economic constraints are a common explanation of why patients with low socioeconomic status tend to experience less access medical care. We tested whether the decreased care extends assistance in dying healthcare system no direct economic constraints. Design Population-based case–control study adults who died. Setting Ontario, Canada, between 1 June 2016 and 2019. Patients receiving palliative under universal insurance user fees. Exposure Patient’s identified using standardised...
Acute myocardial infarction is expected to be an important medical complication following ischaemic stroke. We sought describe the frequency and clinical impact of in-hospital acute stroke.Consecutive patients with stroke were identified from Registry Canadian Stroke Network (2003-2006). severity was measured using Neurological Scale (CNS). Functional status at discharge modified-Rankin Scale, categorized into strokes no or mild-moderate dependency (m-Rankin 0-3) those severe dependence...