A5100337543- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Immunodeficiency and Autoimmune Disorders
- Tendon Structure and Treatment
- Laser Applications in Dentistry and Medicine
- Platelet Disorders and Treatments
- Biosimilars and Bioanalytical Methods
- Orthopedic Surgery and Rehabilitation
- Foot and Ankle Surgery
- Protein Degradation and Inhibitors
- Bone health and treatments
- Viral-associated cancers and disorders
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Glioma Diagnosis and Treatment
- Bone health and osteoporosis research
- Bone and Joint Diseases
- Multiple Myeloma Research and Treatments
- Microfluidic and Bio-sensing Technologies
- Bee Products Chemical Analysis
- Anorectal Disease Treatments and Outcomes
- Complement system in diseases
- MicroRNA in disease regulation
- Cytokine Signaling Pathways and Interactions
- Lipoproteins and Cardiovascular Health
- Shoulder Injury and Treatment
Shanghai University of Traditional Chinese Medicine
2018-2024
Tianjin Medical University General Hospital
2023
Shenyang Pharmaceutical University
2023
Tianjin Huanhu Hospital
2023
Nantong University
2021
Fudan University
2017-2019
Zhongda Hospital Southeast University
2017-2019
Huashan Hospital
2017-2019
Southeast University
2019
Shanghai Sixth People's Hospital
2019
// Yu-Cheng Lin 1,* , Ying-Juan Li 2,* Yun-Feng Rui 1,3,4 Guang-Chun Dai 1 Liu Shi 1,5,6 Hong-Liang Xu 3 Ming Ni 7 Song Zhao Hui Chen Wang Gang 5,6 and Gao-Jun Teng 8 Department of Orthopaedics, Zhongda Hospital, School Medicine, Southeast University, Nanjing, Jiangsu, China 2 Geriatrics, Xishan People's Wuxi, 4 Orthopedic Regenerative Medicine Group, 5 Orthopaedics Traumatology, Faculty The Chinese University Hong Kong, SAR, 6 Program Stem Cell Regeneration, Biomedical Science, Ka Shing...
This paper reports the first study of stiffness/deformability changes lymphocytes in chronic lymphocytic leukemia (CLL) patients, demonstrating that at single cell level, leukemic metastasis progresses are accompanied by biophysical property alterations. A microfluidic device was utilized to electrically measure volume and transit time from healthy CLL patients. The results testing thousands cells reveal patients have higher stiffness (i.e., lower deformability), as compared samples, which...
In order to accelerate the tendon-bone healing processes and achieve efficient osteointegration between tendon graft bone tunnel, we aim design bioactive electrospun nanofiber membranes combined with stem/progenitor cells (TSPCs) promote osteogenic regeneration of interface.In this study, polycaprolactone (PCL), PCL/collagen I (COL-1) hybrid membranes, poly(dopamine) (PDA)-coated PCL PDA-coated PCL/COL-1 were successfully fabricated by electrospinning. The biochemical characteristics...
Patients with diabetes mellitus (DM) often suffered many musculoskeletal disorders, such as tendon rupture and tendinopathy. However, the understanding of pathogenesis these alternations is limited. This study was designed to investigate role tendon-derived stem cells (TDSCs) in histopathological alterations DM tendons. Forty-two SD rats were randomly equally divided into a group (DG) control (CG). induced by streptozotocin (65 mg/kg). The patellar tendons isolated at weeks 1, 2, 4 for...
The finding of monoclonal B-cell lymphocytosis (MBL) raises questions on the nature clonal cell expansion and its risk progression. We identified characterized 7 cases clinically benign lymphocytosis. lymphocytes were clearly CD5- non-chronic lymphocytic leukemia (CLL) phenotype. All had mild to moderate absolute population accounted for 95% 99% B cells. For a follow-up period 4 16 years, was persistent but virtually not progressing. Patients' conditions remained stable asymptomatic....
OBJECT The purpose of this study was to explore the clinical features and outcome medulloblastoma in Chinese children. authors analyze reasons that treatment is abandoned attempt provide evidence-based recommendations for improving prognosis population. METHODS A total 67 pediatric cases newly diagnosed were included study. All children treated at Xinhua Hospital between January 2007 June 2013. retrospectively analyzed data, modalities, outcome. male-to-female ratio 2:1, patients’ median age...
Aims To evaluate the potential ethnic differences in pharmacokinetics (PK) and pharmacodynamics (PD) of evolocumab Caucasian Asian populations using population PK/PD modelling analysis. Methods Data from different groups 5 Phase I clinical trials, including two American studies, one Japanese study Chinese were chosen for model building evaluation. A target‐mediated drug disposition together with an indirect response best captured binding removal unbound proprotein convertase subtilisin/kexin...
Abstract Monoclonal B lymphocytosis of undetermined significance (MLUS) is a benign condition clonal lymphocytosis. Because its small lymphocytes and indolent clinical course, MLUS resembles may be indistinguishable from an early stage chronic lymphocytic leukemia (CLL). In this study we characterized the immunophenotype MLUS. The three patients typical were shown to CD5 − CD23 phenotype. Their immunophenotypic features remained unchanged during course. results indicate distinct that can...
The objective of the current study is to compare reliability, accuracy, sensitivity, and specificity in magnetic resonance imaging (MRI) evaluation anterior talofibular ligament (ATFL) among routine axial scanning plane, oblique axial-coronal axial-sagittal plane.Twenty cadaveric feet were studied. ATFL was exposed before scanning. Routine axial, axial-coronal, MRI 20 ATFL-intact acquired utilizing a 1.5-T unit. scans repeated on after artificially injured. In total, 120 sets MR images...
An 82-year-old man presented with leukocytosis and splenomegaly. His blood counts showed a white cell count of 134 × 109/l, hemoglobin 96 g/l, platelet 86 109/l. The film two distinct populations lymphocytes, morphologically, 60% typical CLL cells 40% large prolymphocytes (Image 1). Patient's spleen was palpable 14 cm below the left costal margin. There were mildly enlarged cervical axillary lymph nodes up to 2 but no evidence localized lymphoma. Blood shows PLL cells. Flow cytometry...
ABSTRACT The morphology of cells and expression status specific surface markers [cluster differentiation (CD)], such as CD5, CD19, CD20, CD38, CD45, have long been considered the essential indicators for diagnosis prognosis B‐cell chronic lymphocytic leukemia (B‐CLL). Clinically, it is difficult to simultaneously obtain cell distribution with flow cytometry, especially some surrogate CD38. Here, an alternative complementary prognostic method, fluorescence microscopy image processing method...
Clonal expansion of lymphocytes may account for asymptomatic lymphocytosis. Unlike monoclonal B lymphocytosis, the detection T-cell clones is difficult using immunophenotype-based assays. This study aimed to evaluate PCR-based clonality assays identification among patients with unexplained lymphocytosis.We incorporated BIOMED-2 multiplex PCR into investigation peripheral Clonality analysis was performed three reactions TCRβ and two TCRγ gene rearrangements. The blood specimens from a total...
<title>Abstract</title> OBJECTIVE To study the clinical efficacy and safety of a novel procedure,Trans-intersphincteric Double Seton, for treatment perianal abscesses in sciorectal hiatus. METHODS The population consisted patients with abscess space who underwent Trans-intersphincteric Seton (TRISDS) Incision Drainage (I&D) from September 2020 to 2023 at Affiliated Hospital Jiangxi University Traditional Chinese Medicine. cure rate, hospitalization time, wound healing Wexner score anal...
The ease and flexibility of functionalization inherent light scattering properties plasmonic nanoparticles make them suitable contrast agents for measurement cell surface markers. Immunophenotyping lymphoproliferative disorders is traditionally undertaken using fluorescence detection methods which have a number limitations. Herein, surface-enhanced Raman (SERS) gold conjugated to monoclonal antibodies are used the selective targeting CD molecules on chronic lymphocytic leukemia (CLL) cells....
A 25-year-old man presented with chronic haemolytic anaemia. The blood count showed Hb 78 g/l, MCV 91·5 fl, MCH 24·1 pg, WBC 15·6 × 109/l, platelets 671 reticulocytes 428 109/l (13·5%) and nucleated red cells 54 109/l. film marked anisocytosis poikilocytosis, basophilic stippling, fragments, polychromasia circulating erythroblasts. bilirubin level was persistently elevated: total 80–110 μmol/l, indirect 68–92 μmo/l (normal 1–16 μmol/l). patient had been identified in infancy as having...
Background. Gliomas are the most common malignant tumors of central nervous system. However, inherited genetic variation in gliomas is presently unclear. Therefore, this study investigated association rs2071559 and rs2239702 gene polymorphisms with glioma susceptibility Chinese patients. Methods. In study, a case-control approach was used to compare analyze whether two genes, rs2239702, were associated risk formation. Results. The cases controls matched for sex, smoking status, family...