A5008746670- Acute Lymphoblastic Leukemia research
- Rheumatoid Arthritis Research and Therapies
- Chronic Lymphocytic Leukemia Research
- Anesthesia and Sedative Agents
- Cancer Treatment and Pharmacology
- Lung Cancer Treatments and Mutations
- Neutropenia and Cancer Infections
- Pharmaceutical Practices and Patient Outcomes
- Autoimmune and Inflammatory Disorders Research
- Glioma Diagnosis and Treatment
- Ubiquitin and proteasome pathways
- Anesthesia and Neurotoxicity Research
- Mycobacterium research and diagnosis
- Microscopic Colitis
- Colorectal Cancer Treatments and Studies
- Optical Imaging and Spectroscopy Techniques
- Chronic Disease Management Strategies
- Angiogenesis and VEGF in Cancer
- Adolescent and Pediatric Healthcare
- Chemotherapy-induced organ toxicity mitigation
- Health Sciences Research and Education
- Sports Performance and Training
- Sports injuries and prevention
- Parvovirus B19 Infection Studies
- Cancer Research and Treatments
Nanium (Portugal)
2025
Cooperativa de Ensino Superior Politécnico e Universitário
2014-2022
Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde
2015-2022
Hospital de São João
2022
Universidade do Porto
2014-2021
University of Houston
2016-2019
Methodist Hospital
2018
Houston Methodist
2018
Cornell University
2018
Weill Cornell Medicine
2018
Vancomycin is a fundamental antibiotic in the management of severe Gram-positive infections. Inappropriate vancomycin dosing associated with therapeutic failure, bacterial resistance and toxicity. Therapeutic drug monitoring (TDM) acknowledged as an important part therapy management, at least specific patient subpopulations, but implementation clinical practice has been difficult because there are no consensus agglutinator documents. The aims present work to overview current knowledge on TDM...
Methotrexate (MTX) is used for rheumatoid arthritis (RA) treatment showing a wide toxicity profile. This study aimed to evaluate the influence of single nucleotide polymorphisms (SNPs) in genes encoding MTX transporters with occurrence MTX-related (overall and gastrointestinal). A total 233 Portuguese RA patients were genotyped 23 SNPs. Haplotype analyses performed toxicogenetic risk index (TRI) was created SNPs that revealed be statistically significant. Regarding overall toxicity, an...
The escalating trend of inappropriate visits to Emergency Departments (ED) has led significant concerns, including resource misallocation, compromised patient care, and an increased burden on healthcare workers. Portugal faces a notable challenge, reporting one the highest per capita ED visit rates, with annual average approximately 6 million from 2013 2023. In response, “Call First, Save Lives” pilot project was launched by Portuguese NHS Executive Board, in 2023, at Local Health Unit (LHU)...
Objective. Methotrexate (MTX), the most used drug in rheumatoid arthritis (RA) treatment, showing variability clinical response, is often associated with genetic polymorphisms. This study aimed to elucidate role of methylenetetrahydrofolate reductase ( MTHFR ) C677T and aminoimidazole carboxamide adenosine ribonucleotide transformylase ATIC T675C polymorphisms clinicopathological variables response MTX Portuguese RA patients. Methods. Study included 233 patients treated for at least six...
Biochemical and biophysical cues governing glioblastoma (GBM) progression are complex dynamic. Tumor blood vessels, often recognized only by their transport functions, more deeply involved in this process. Vessels tumor immune evasion, matrix alterations stem cell stimulation, contributing for treatment resistance patients’ poor survival. Given vessel dynamic nature, they hardly represented conventional GBM monolayered vitro models. However, other approaches, such as three-dimensional (3D)...
Background The permutation entropy, the approximate and index of consciousness are some most recently studied electroencephalogram-derived indexes. In this work, a thorough comparison these indexes was performed using propofol anesthesia in rabbit model. Methods Six rabbits were anesthetized with three infusion rates: 70, 100, 130 mg · kg⁻¹ h⁻¹, each maintained for 30 min, random order animal. Data recording awake animals 20, 25, min after rate begun recovered consisted electroencephalogram...
Propofol is an anaesthetic widely used in both human beings and animals. However, the characterization of propofol pharmacokinetics (PK) not well understood when long-term infusions are used. The main objective this study was to explore PK behaviour a rabbit model during short prolonged develop internally validated model, for dose individualization future use. Population 1 (P1) constituted by seven New Zealand rabbits characterize profile at infusions. Animals were anaesthetized with bolus...
Abstract: The aim of this study was to evaluate systemic exposure carboplatin and its haematological toxicity in patients with advanced non-small cell lung cancer both older younger than 70 years when the target area under curve (AUC) elderly reduced by 20%. For purpose, a population pharmacokinetic model developed drug assessed. A total 33 received on day 1 gemcitabine (1250 mg/m2) days 8. This schedule repeated every 21 days. Calvert–Crokcoft–Gault formula employed calculate dose AUC 5...
<h3>Background</h3> Methotrexate is the mainstay DMARD in RA treatment<sup>1</sup>. Despite its effectiveness, additional DMARDs are often required to achieve recommended goals of low disease activity/remission<sup>1</sup>. Given clinical implications widespread use MTX RA, many studies were conducted evaluate role potential biomarkers predicting effectiveness MTX<sup>2,3</sup>. Nevertheless, there scant information regarding Portuguese population. <h3>Objectives</h3> To determine possible...
Abstract Triple negative breast cancer (TNBC) still remains a challenge to treat in the clinic due lack of good targets for treatment. Although TNBC lacks expression ERα, ERβ and its variants are detected quite frequently this type can represent an avenue We show that ERβ, namely ERβ1, ERβ2, ERβ4, ERβ5, contributes aggressiveness cell line HCC1806 by affecting E-Cadherin chemotherapy sensitivity. have previously shown expresses all variants. To investigate their function we used recently...
Abstract Recent clinical studies are indicating that the estrogen receptor β variant β5 (ERβ5) expression correlates to worse prognosis. We wanted know if of ERβ5 is changing growth behavior triple negative cell line SUM159. Estrogen highly similar β1 except for a truncated C-terminus making remaining ligand binding domain incapable estrogen. In addition 4 amino acid unique peptide added C-terminal end. Stably expressing using transposon integrated tetracycline regulated system we find...
<h3>Background</h3> Methotrexate is the cornerstone of treatment RA<sup>1</sup>. However, major drawbacks MTX therapy are large interpatient variability in clinical response and unpredictable appearance a spectrum side effects<sup>1</sup>. Several studies have been conducted to evaluate role potential biomarkers predicting MTX-related toxic effects<sup>2,3</sup>. Nevertheless, there no information regarding Portuguese population. <h3>Objectives</h3> To determine possible toxicity with...
s and Programme: EUROANAESTHESIA 2011: The European Anaesthesiology Congress: Monitoring: Equipment Computers
Abstract Triple negative breast cancer (TNBC) still remains a challenge to treat in the clinic due lack of good targets for treatment. Although TNBC lacks expression ERα, ERβ and its variants are detected quite frequently this type can represent an avenue We show that ERβ, namely ERβ1, ERβ2, ERβ4, ERβ5, regulate aggressiveness by regulating hypoxic signaling. RNA-seq patient derived xenografts (PDX) from ERβ4 ERβ5 more than half samples. Furthermore, immortalized, normal mammary epithelial...