A5000767502- Nanoparticle-Based Drug Delivery
- Advanced Drug Delivery Systems
- Nanoplatforms for cancer theranostics
- biodegradable polymer synthesis and properties
- Extracellular vesicles in disease
- Glioma Diagnosis and Treatment
- Barrier Structure and Function Studies
- Innovative Microfluidic and Catalytic Techniques Innovation
- Graphene and Nanomaterials Applications
- Electrospun Nanofibers in Biomedical Applications
- RNA Interference and Gene Delivery
- MicroRNA in disease regulation
- Bone Tissue Engineering Materials
- Cancer Research and Treatments
- Advanced biosensing and bioanalysis techniques
- Glycosylation and Glycoproteins Research
- Drug Solubulity and Delivery Systems
- Microfluidic and Capillary Electrophoresis Applications
- Edible Oils Quality and Analysis
- Immune cells in cancer
- Dye analysis and toxicity
- Catalysis for Biomass Conversion
- Fermentation and Sensory Analysis
- Free Radicals and Antioxidants
- Tea Polyphenols and Effects
i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto
2017-2025
Polytechnic Institute of Bragança
2024-2025
Universidade do Porto
2015-2024
University of Nottingham
2019-2020
Cooperativa de Ensino Superior Politécnico e Universitário
2018-2019
Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde
2018-2019
Centro Hospitalar Tondela-Viseu
2015-2018
Abstract Fully simulating the components and microstructures of soft tissue is a challenge for its functional regeneration. A new aligned hydrogel microfiber scaffold spinal cord regeneration constructed with photocrosslinked gelatin methacryloyl (GelMA) electrospinning technology. The directional porous fibrous consistent nerve axons vital to guide cell migration axon extension. GelMA electrospun fibers soak up water more than six times their weight, lower Young's modulus, providing...
Abstract Minimal therapeutic advances have been achieved over the past two decades for glioblastoma (GBM), which remains an unmet clinical need. Here, hypothesis‐driven stimuli‐responsive nanoparticles (NPs) docetaxel (DTX) delivery to GBM are reported, with multifunctional features that circumvent insufficient blood‐brain barrier (BBB) trafficking and lack of targeting—two major hurdles anti‐GBM therapies. NPs dual‐surface tailored a i) brain‐targeted acid‐responsive Angiopep‐2 moiety...
The competitive adsorption of phenolic acids, secoiridoids, and flavonoids in a molecularly imprinted polymer (MIP) functionalized with 4-vinylpiridine (4VP) moieties is analyzed here considering vanillic acid, oleuropein, quercetin as reference molecules. Measured isotherms highlight much stronger binding capacity the quercetin-MIP particles toward compared acid oleuropein. acquired data were used to design scale-up sorption/desorption processes aiming at fractionation olive leaf extracts....
Despite research efforts to discover new drugs for Parkinson treatment, the majority of candidates fail in preclinical and clinical trials due inadequate pharmacokinetic properties, namely blood-brain barrier permeability. Within high demand introduce market, nanotechnology can be used as a solution. Accordingly, PEGylated PLGA nanoparticles (NPs) were smart delivery carrier solve suboptimal aqueous solubility, which precludes its use vivo assays, potent, reversible, selective monoamine...
The separation of different types bioactive compounds in olive leaf is demonstrated with a tailored adsorbent functionalized pyridyl moieties and sorption–desorption processes developed to use only hydroalcoholic solvents. competitive binding isotherms mixtures vanillic acid, oleuropein, quercetin, maslinic, oleanolic acids water/ethanol solvents, the composition ranging from 50/50 up 100% ethanol, prove feasibility such classes molecules. two industrial extracts crude compositions were...
Background: Actually, no drugs provide therapeutic benefit to approximately one-third of depressed patients. Depression is predicted become the first global disease by 2030. So, new interventions are imperative.Research design and methods: Venlafaxine-loaded poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) were surface functionalized with two ligands against transferrin receptor enhance access brain. An in vitro blood–brain barrier model using hCMEC/D3 cell line was developed...
Demyelinating disorders, with a particular focus on multiple sclerosis (MS), have multitude of detrimental cognitive and physical effects the patients. Current treatment options that involve substances promoting remyelination fail in clinics due to difficulties reaching central nervous system (CNS). Here, dual encapsulation retinoic acid (RA) into lipid nanocapsules nominal size 70 nm, low PdI 0.1, coupled super paramagnetic iron oxide nanoparticles (SPIONs) was accomplished, joined by an...
The uptake and transport of dietary antioxidants remains the most important setback for their application in therapy. To overcome limitations, a PEGylated-based platform was developed to improve delivery properties two hydroxycinnamic (HCA) antioxidants-caffeic ferulic acids. antioxidant new polymer-antioxidant conjugates (PEGAntiOxs), prepared by linking poly(ethylene glycol) (PEG) cinnamic acids one-step Knovenagel condensation reaction, were evaluated. PEGAntiOxs present higher...
Biochemical and biophysical cues governing glioblastoma (GBM) progression are complex dynamic. Tumor blood vessels, often recognized only by their transport functions, more deeply involved in this process. Vessels tumor immune evasion, matrix alterations stem cell stimulation, contributing for treatment resistance patients’ poor survival. Given vessel dynamic nature, they hardly represented conventional GBM monolayered vitro models. However, other approaches, such as three-dimensional (3D)...
Abstract Inflammatory Bowel Disease (IBD) is a chronic inflammatory condition affecting the gastrointestinal tract (GIT). Glucagon‐like peptide‐2 (GLP‐2) analogs possess high potential in treatment of IBD by enhancing intestinal repair and attenuating inflammation. Due to enzymatic degradation poor absorption, GLP‐2 are administered parenterally, which leads patient compliance. This work aims develop IBD‐targeted nanoparticles (NPs) for oral delivery analog, Teduglutide (TED). Leveraging...
Glioblastoma (GBM) is the deadliest adult brain cancer. The current standard-of-care chemotherapy using orally administered temozolomide (TMZ) presents poor improvement in patient survival, emphasizing compelling need for new therapies. A possible chemotherapeutic alternative docetaxel (DTX), which possesses higher tumoricidal potency against GBM cells. However, its limited blood-brain barrier (BBB) permeability poses a constraint on application. Nonetheless, nanomedicine offers promising...
Despite being the most prevalent and lethal type of adult brain cancer, glioblastoma (GBM) remains intractable. Promising anti-GBM nanoparticle (NP) systems have been developed to improve anti-cancer performance difficult-to-deliver therapeutics, with particular emphasis on tumor targeting strategies. However, current disease modeling toolboxes lack close-to-native in vitro models that emulate GBM microenvironment bioarchitecture, thus partially hindering translation due poorly predicted...