A5025548061- Respiratory Support and Mechanisms
- Neonatal Respiratory Health Research
- Pneumonia and Respiratory Infections
- Respiratory viral infections research
- Advanced Drug Delivery Systems
- Hemoglobinopathies and Related Disorders
- Cardiac Arrest and Resuscitation
- Tendon Structure and Treatment
- Pediatric Pain Management Techniques
- Cellular Mechanics and Interactions
- Nosocomial Infections in ICU
- Neonatal Health and Biochemistry
- Family and Patient Care in Intensive Care Units
- Electrolyte and hormonal disorders
- Airway Management and Intubation Techniques
- Healthcare Regulation
- Takotsubo Cardiomyopathy and Associated Phenomena
- COVID-19 diagnosis using AI
- Child and Adolescent Health
- Nanoparticle-Based Drug Delivery
- Surfactants and Colloidal Systems
- Iron Metabolism and Disorders
- Ion Transport and Channel Regulation
- Maternal and Neonatal Healthcare
- Adolescent and Pediatric Healthcare
Hospital Prof. Dr. Fernando Fonseca
2013-2024
Universidade do Porto
2021-2024
i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto
2021-2024
University of Aveiro
2022
University of Minho
2019-2021
Centro Hospitalar Lisboa Norte
2019
Nationwide Children's Hospital
2019
The Ohio State University
2019
Universidade Católica Portuguesa
2018
Sociedad Española de Cuidados Intensivos Pediátricos
2017
Mental health literacy (MHL) is considered a prerequisite for early recognition and intervention in mental disorders, this reason, it has become focus of research over the past few decades. Assessing construct relevant identifying knowledge gaps erroneous beliefs concerning issues, to inform development interventions aimed at promoting as well evaluation these interventions. Recently, we developed new self-reporting measure (MHLq) assessing young people (12–14 years-old), meeting need assess...
The aim of this paper is to assess the clinical efficacy non-invasive ventilation (NIV) in avoiding endotracheal intubation (ETI), demonstrate and gasometric improvement identify predictive risk factors associated with NIV failure. An observational prospective study was carried out. Included Patients acute respiratory disease (ARD) treated NIV, from November 2006 January 2010 a Pediatric Intensive Care Unit (PICU). used 151 patients failure (ARF). were divided two groups: success failure, if...
Objective: To describe the characteristics and outcomes of mechanical ventilation in pediatric intensive care units during season acute lower respiratory infections. Design: Prospective cohort infants children receiving for at least 12 hrs. Setting: Sixty medical-surgical units. Patients: All consecutive patients admitted to participating a 28-day period. Measurements Main Results: Of 2,156 units, 1185 (55%) received median 5 days (interquartile range 2–8). Median age was 7 months 2–25)....
Tendon tissue engineering strategies that recreate the biophysical and biochemical native microenvironment have a greater potential to achieve regeneration. Here, we developed tendon biomimetic scaffolds using mechanically competent yarns of poly-ε-caprolactone, chitosan, cellulose nanocrystals inherent hierarchy from nano-to-macro scale. These were then coated with tropoelastin (TROPO) through polydopamine (PDA) linking, mimic extracellular matrix (ECM) composition elasticity. Both PDA...
Objectives This multicenter study examines the performance of Manchester Triage System (MTS) after changing discriminators, and with addition use abnormal vital sign in patients presenting to pediatric emergency departments (EDs). Design International Settings EDs two hospitals The Netherlands (2006–2009), one Portugal (November–December 2010), UK (June–November 2010). Patients Children (<16years) triaged MTS who presented at ED. Methods Changes discriminators (MTS 1) value including signs...
Abstract Inflammatory Bowel Disease (IBD) is a chronic inflammatory condition affecting the gastrointestinal tract (GIT). Glucagon‐like peptide‐2 (GLP‐2) analogs possess high potential in treatment of IBD by enhancing intestinal repair and attenuating inflammation. Due to enzymatic degradation poor absorption, GLP‐2 are administered parenterally, which leads patient compliance. This work aims develop IBD‐targeted nanoparticles (NPs) for oral delivery analog, Teduglutide (TED). Leveraging...
Orally delivered therapeutics offer great promise for localized treatment of colorectal cancer. However, various natural barriers along the gastrointestinal tract need to be tackled allow effective drug delivery tumoral sites.
This work is focused on the study of sprays produced by pressure atomizers single-hole type when subjected to air crossflows at atmospheric pressure. The was carried out in a wind tunnel. Prior spray characterization, airflow inside tunnel evaluated with aid laser Doppler anemometry. were first characterized using shadowgraphy technique, which allowed for qualitative evaluation overall quality atomization. Subsequently, use phase anemometry performing detailed measurements droplet diameters...
The aim of the study was to describe experience with high-frequency oscillatory ventilation (HFOV) in a Portuguese Pediatric Critical Care Unit, and evaluate whether HFOV allowed improvement oxygenation ventilation.This retrospective observational cohort children ventilated by between January, 2002 December, 2011. following parameters were recorded: demographic clinical data, blood gases ventilatory during first 48 hours HFOV.80 included, median age 1.5 months (min: one week; max: 36...
Atrioventricular block can occur in normal children, young adults or athletes. It is also associated with underlying heart disease occurs as a drug adverse effect. Amphotericin B used the treatment of invasive fungal infections. Cardiac toxicity rare reaction. We report case 9-month girl, admitted paediatric intensive care unit cytomegalovirus pneumonitis. During hospitalisation patient developed systemic fungic infection and was medicated liposomal amphotericin B. On third day she began...
To study the effect of two intravenous maintenance fluids on plasma sodium (Na), and acid–base balance in pediatric intensive care patients during first 24 h hospitalization. A prospective randomized controlled was performed, which allocated 233 to groups: (A) NaCl 0.9% or (B) 0.45%. Patients were aged 1 day 18 years, had normal electrolyte concentrations, suffered an acute insult (medical/surgical). Main outcome measured: change sodium. Parametric tests: t-tests, ANOVA, X2 statistical...
Hypercalcemia is a rare metabolic disorder in children and potentially fatal. It has wide differential diagnosis, including cancer. Here, we report the case of previously healthy 3-year-old who was admitted to emergency room with fatigue, hyporeactivity, fever limping gait that had evolved over 5 days progressively worsening. On examination patient unconscious (Glasgow coma score: 8). Laboratory tests indicated severe hypercalcemia (total calcium 21.39mg/dL, ionized 2.93mmol/L) microcytic...
Plastic pollution is a serious problem in aquatic systems throughout the world. Despite increasing number of studies addressing impact macro- and microplastics on biota, there still significant knowledge gap regarding effects nanoplastics alone combination with other contaminants. Among contaminants that may interact arsenic (As), metalloid found estuarine coastal ecosystems, pernicious to benthic organisms. This study aimed understand how parental pre-exposure 100 nm polystyrene (PS NPs)...
To determine the prevalence of pre-hypertension (pre-HTN) and hypertension (HTN) in Portuguese adolescents Lisbon to ascertain relationship between blood pressure (BP) levels risk factors gender, obesity, smoking, alcohol consumption, exercise family history HTN.This was a cross-sectional study non-randomized sample 234 both sexes, aged 16 19 years. Information on habits HTN obtained through self-completed structured questionnaire.The included adolescents, mean age 16.4±0.9 years, 57% male....
To determine the prevalence of pre-hypertension (pre-HTN) and hypertension (HTN) in Portuguese adolescents Lisbon to ascertain relationship between blood pressure (BP) levels risk factors gender, obesity, smoking, alcohol consumption, exercise family history HTN. This was a cross-sectional study non-randomized sample 234 both sexes, aged 16 19 years. Information on habits HTN obtained through self-completed structured questionnaire. The included adolescents, mean age 16.4 ± 0.9 years, 57%...
The benefits of manual versus automated red blood cell exchange have rarely been documented and studies in young sickle disease patients are scarce. We aim to describe compare our experience these two procedures.Young (≤ 21 years old) who underwent manual- or automated-red for prevention treatment complications were included. Clinical, technical hematological data prospectively recorded analyzed.Ninety-four sessions performed over a period 68 months, including 57 37 automated, 63 chronic...