A5101743261- Microscopic Colitis
- Inflammatory Bowel Disease
- Nanoparticle-Based Drug Delivery
- Advanced Drug Delivery Systems
- 3D Printing in Biomedical Research
- Inflammation biomarkers and pathways
- Cancer, Hypoxia, and Metabolism
- Health Systems, Economic Evaluations, Quality of Life
- Drug Solubulity and Delivery Systems
- Pharmaceutical Practices and Patient Outcomes
- Nanoplatforms for cancer theranostics
- Cerebrospinal fluid and hydrocephalus
- Neuroblastoma Research and Treatments
- Barrier Structure and Function Studies
- Biomedical and Engineering Education
- Advancements in Transdermal Drug Delivery
- Renal and related cancers
- RNA Interference and Gene Delivery
- Glioma Diagnosis and Treatment
- Cancer Cells and Metastasis
- Neonatal and fetal brain pathology
- Single-cell and spatial transcriptomics
- Heart Failure Treatment and Management
- Chemical Reactions and Isotopes
Homerton University Hospital
2024
i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto
2023-2024
Universidade do Porto
2023-2024
European Southern Observatory
2023
Inflammatory bowel disease (IBD) encompasses a set of chronic inflammatory conditions, namely Crohn's and ulcerative colitis. Despite all advances in the management IBD, definitive cure is not available, largely due to lack holistic understanding its etiology pathophysiology. Several vitro, vivo, ex vivo models have been developed over past few decades order abbreviate remaining gaps. The establishment reliable predictable vitro intestinal inflammation may indeed provide valuable tools...
Resveratrol (RES) is a biopharmaceutical classification system (BCS) class II compound with low solubility and high permeability. Several strategies have been explored to overcome the bioavailability of RES, making formation solid dispersions (SDs) one most promising. This study aimed at development RES third-generation SD prepared by lyophilization as strategy improve solubility, dissolution, oral bioavailability. Eudragit E PO was selected hydrophilic carrier in 1:2 (RES:carrier) ratio,...
Abstract The rising global prevalence of Inflammatory Bowel Disease (IBD) and its significant socio-economic impact highlight the urgent need to develop innovative solutions overcome poor targeting efficiency short retention time faced by current treatments. Hence, aim this work was use an advanced oxidative-responsive nanosystem selectively target accumulate at inflamed tissues for oral administration budesonide, a corticosteroid used treat intestinal inflammation. For system,...
Abstract The encapsulation of bevacizumab (BVZ), angiogenesis inhibitor antibody, into nanocarriers is explored aiming at enhancing its efficacy in colorectal cancer (CRC) treatment while eliminating potential side effects. Still, the translation such nanomedicines clinics not straightforward owing to their preclinical screening simplistic models, that do mimic complexity and heterogeneity CRC microenvironment. Herein, development a multicellular spheroid as an advanced model capable...
Orally delivered therapeutics offer great promise for localized treatment of colorectal cancer. However, various natural barriers along the gastrointestinal tract need to be tackled allow effective drug delivery tumoral sites.
<h3>Introduction</h3> Heart failure (HF) mortality rates continue to pose a significant challenge despite advancements in recent decades – the UK, one-year are approximately 20%, ranging up 30% globally among HF patients.1, 2 Of note, elderly individuals, substantial segment of population, face particularly high rates.3 Reduced left ventricular ejection fraction (EF) is key prognostic element HF, and so target for intervention.4, 5 The strategic introduction uptitration evidence-based...
Abstract BACKGROUND Pediatric brain tumors (PBT) are the leading cause of non-accidental death in pediatric age. These rare and lack adequate experimental models capable accurately capturing their complex molecular landscape. METHODS AND RESULTS Our team has established specific protocols for generation expansion ex-vivo patient-derived organoids (PDO) from fresh surgical material a variety PBT, within clinically relevant timeframe. include pilocytic astrocytomas, pleomorphic...