A5033177639- RNA Interference and Gene Delivery
- Advancements in Transdermal Drug Delivery
- 3D Printing in Biomedical Research
- Advanced Drug Delivery Systems
- Immunotherapy and Immune Responses
- Dermatology and Skin Diseases
- Cancer Cells and Metastasis
- Silk-based biomaterials and applications
- Cellular Mechanics and Interactions
- Nanoparticle-Based Drug Delivery
- Drug Solubulity and Delivery Systems
- Nanoplatforms for cancer theranostics
- Microscopic Colitis
- Inflammation biomarkers and pathways
- Nanoparticles: synthesis and applications
- Innovative Microfluidic and Catalytic Techniques Innovation
- Inflammatory Bowel Disease
- S100 Proteins and Annexins
- Skin Protection and Aging
- Extracellular vesicles in disease
- Sperm and Testicular Function
- Salivary Gland Disorders and Functions
- Hydrogels: synthesis, properties, applications
- Polymer Nanocomposite Synthesis and Irradiation
- Graphene and Nanomaterials Applications
Universidade de São Paulo
2009-2024
i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto
2023-2024
Universidade do Porto
2024
Weatherford College
2024
Centro de Investigacion Principe Felipe
2022
Universidad de Especialidades
2022
SUPERA Park of Innovation and Technology of Ribeirão Preto
2022
Universidade de Ribeirão Preto
2020-2022
Universidade Federal de Ouro Preto
2019
Universidade Federal de Minas Gerais
2017
Melanoma, the deadliest form of skin cancer, poses a significant clinical challenge for development effective treatments. Conventional in vivo animal studies have shown limited translational relevance to humans, raising strength pre-clinical models melanoma research. This review provides an in-depth analysis alternative including vitro and ex platforms such as reconstructed skin, spheroids, organoids, organotypic models, skin-on-a-chip, bioprinting. Through comprehensive analysis, specific...
Inflammatory bowel disease (IBD) encompasses a set of chronic inflammatory conditions, namely Crohn's and ulcerative colitis. Despite all advances in the management IBD, definitive cure is not available, largely due to lack holistic understanding its etiology pathophysiology. Several vitro, vivo, ex vivo models have been developed over past few decades order abbreviate remaining gaps. The establishment reliable predictable vitro intestinal inflammation may indeed provide valuable tools...
Abstract The rising global prevalence of Inflammatory Bowel Disease (IBD) and its significant socio-economic impact highlight the urgent need to develop innovative solutions overcome poor targeting efficiency short retention time faced by current treatments. Hence, aim this work was use an advanced oxidative-responsive nanosystem selectively target accumulate at inflamed tissues for oral administration budesonide, a corticosteroid used treat intestinal inflammation. For system,...
We report an enhanced X-ray shielding effect related to graphene. The mass attenuation coefficients measured for nanocomposites made of poly(vinylidene fluoride) (PVDF) filled with 1.88 wt % functionalized graphene oxides (GO), pyrolytic graphite (PG), multiwalled carbon nanotubes (MWCNT), and amorphous (soot) have been compared. For 6.9 keV photons, the value graphene-based nanocomposite was found be four times higher than that encountered other graphitic-based nanocomposites. were photons...
We developed poly-ε-caprolactone (PCL)-based nanoparticles containing D-α-tocopherol polyethylene glycol-1000 succinate (TPGS) or Poloxamer 407 as stabilizers to efficiently encapsulate genistein (GN). Two formulations, referred PNTPGS and PNPol, were prepared using nanoprecipitation. They characterized by size PDI distribution, zeta potential, nanoparticle tracking analysis (NTA), GN association (AE%), infrared spectroscopy (FT-IR), differential scanning calorimetry (DSC). PNTPGS-GN...
Abstract Inflammatory Bowel Disease (IBD) is a chronic inflammatory condition affecting the gastrointestinal tract (GIT). Glucagon‐like peptide‐2 (GLP‐2) analogs possess high potential in treatment of IBD by enhancing intestinal repair and attenuating inflammation. Due to enzymatic degradation poor absorption, GLP‐2 are administered parenterally, which leads patient compliance. This work aims develop IBD‐targeted nanoparticles (NPs) for oral delivery analog, Teduglutide (TED). Leveraging...
The physicochemical characteristics of nanostructured suspensions are important prerequisites for the success new drug development. This work aimed to develop nanometric systems containing Cymbopogon densiflorus leaf essential oil and evaluate their antimicrobial activity. was isolated by hydrodistillation from leaves analyzed GC-MS. main constituents were found be trans-p-mentha-2,8-dien-1-ol, cis-p-mentha-2,8-dien-1-ol, trans-p-mentha-1(7),8-dien-2-ol, cis-piperitol,...
The oral administration of the glucagon-like peptide-1 analogue, semaglutide, remains a hurdle due to its limited bioavailability. Herein, neonatal Fc receptor (FcRn)-targeted nanoparticles (NPs) were designed enhance delivery semaglutide. nanocarriers covalently linked FcRn-binding peptide FcBP or affibody molecule Z
The stratum corneum (SC) is the skin's outermost layer, organized by clusters of corneocytes among a lipid matrix, acting as barrier. This "brick and mortar" organization modified in many skin diseases. We proposed lesioned-skin model for assessing permeability topical formulations impact integrity on molecules. anticipate that removal SC compromises barrier function, making it more permeable, affecting biopharmaceutics formulations. By stripping with 25 strips (Corneofix®), thickness was...
Abstract In vitro models are crucial in cancer research, but they must truthfully mimic vivo tumors for clinical relevance. The development of unprecedent melanoma quadruple multicellular tumoroids (MCTs) is proposed comprising tumor cells, keratinocytes, fibroblasts, and monocytes that replicate architecture, microenvironment, secretome behavior. These MCTs 300 µm diameter secreted keratin collagen, showing complexity proportional to their cell combinations. Further, closely resembled terms...