A5050006070- RNA Interference and Gene Delivery
- Advancements in Transdermal Drug Delivery
- Photodynamic Therapy Research Studies
- Nanoplatforms for cancer theranostics
- Immunotherapy and Immune Responses
- Oral health in cancer treatment
- Silk-based biomaterials and applications
- Extracellular vesicles in disease
- ATP Synthase and ATPases Research
- Mitochondrial Function and Pathology
- Photochromic and Fluorescence Chemistry
- Retinoids in leukemia and cellular processes
- Essential Oils and Antimicrobial Activity
- Metabolism and Genetic Disorders
- Lipid Membrane Structure and Behavior
- Dermatology and Skin Diseases
University of Southern California
2024
Universidade de São Paulo
2015-2021
National Council for Scientific and Technological Development
2016
ABSTRACT Autosomal dominant polycystic kidney disease (ADPKD) is the most common genetic worldwide. The one small molecule drug available to patients, tolvaptan, associated with off‐target side effects and high discontinuation rates, necessitating development of new therapeutic strategies. Previous work has shown that epigenome altered in ADPKD; however, identification targeting dysregulated epigenetic modulators yet be explored for human ADPKD therapy. Using cells derived from cysts we...
Abstract Although cardiovascular diseases (CVD) are the leading cause of global mortality, there is a lack therapies that target and revert underlying pathological processes. Mitochondrial dysfunction involved in pathophysiology CVD, thus potential for therapeutic development. To mitochondria improve efficacy, nanoparticle‐based delivery systems have been proposed as promising strategies agents to mitochondria. This review will first discuss how mitochondrial related progression several CVD...
Because of excessive use antibiotics there is a growth in the number resistant strains. Due to this multiresistant bacteria, searches looking for alternatives antibacterial therapeutic has increased, and among them antimicrobial photodynamic therapy (aPDT) or inactivation (PDI). The involves action photosensitizer (PS), activated by specific wavelength, present oxygen, resulting cytotoxic effect. Natural curcumin, consists mixture three curcuminoids: demethoxycurcumin bis-demethoxycurcumin....