A5044574857- Antimicrobial Peptides and Activities
- Supramolecular Self-Assembly in Materials
- Polydiacetylene-based materials and applications
- Lipid Membrane Structure and Behavior
- Bacterial biofilms and quorum sensing
- Biochemical and Structural Characterization
- Machine Learning in Bioinformatics
- Chemical Synthesis and Analysis
- Click Chemistry and Applications
- Metal-Organic Frameworks: Synthesis and Applications
- Neuropeptides and Animal Physiology
- RNA Interference and Gene Delivery
- Metabolism and Genetic Disorders
- Mitochondrial Function and Pathology
- ATP Synthase and ATPases Research
University of Nebraska Medical Center
2021-2024
University of Southern California
2024
Nebraska Medical Center
2023-2024
Self-assembled nanostructures such as those formed by peptide amphiphiles (PAs) are of great interest in biological and pharmacological applications. Herein, a simple widely applicable chemical modification, urea motif, was included the PA's molecular structure to stabilize virtue intermolecular hydrogen bonds. Since amino acid residue nearest lipid tail is most relevant for stability, we decided include modification at that position. We prepared four groups molecules (13 PAs all), with...
Abstract Antimicrobial peptide amphiphiles (PAs) are a promising class of molecules that can disrupt the bacterial membrane or act as drug nanocarriers. In this study, we prepared 33 PAs to establish supramolecular structure‐activity relationships. We studied morphology and activity nanostructures against different Gram‐positive Gram‐negative strains (such Staphylococcus aureus , Escherichia coli Pseudomonas aeruginosa Acinetobacter baumannii ). Next, used principal component analysis (PCA)...
In recent decades, peptide amphiphiles (PAs) have established themselves as promising self-assembling bioinspired materials in a wide range of medical fields. Herein, we report dual-therapeutic system constituted by an antimicrobial PA and cylindrical protease inhibitor (LJC) to achieve broad spectrum enhance therapeutic efficacy. We studied two strategies: PA–LJC nanostructures ( Encapsulation ) + free LJC Combination ). Computational modeling using molecular theory for amphiphile...
Abstract Although cardiovascular diseases (CVD) are the leading cause of global mortality, there is a lack therapies that target and revert underlying pathological processes. Mitochondrial dysfunction involved in pathophysiology CVD, thus potential for therapeutic development. To mitochondria improve efficacy, nanoparticle‐based delivery systems have been proposed as promising strategies agents to mitochondria. This review will first discuss how mitochondrial related progression several CVD...
Supramolecular nanostructures with tunable properties can have applications in medicine, pharmacy, and biotechnology. In this work, we show that the self-assembly behavior of peptide amphiphiles (PAs) be effectively tuned by replacing carboxylic acids exposed to aqueous media isosteres, functionalities share key physical or chemical another group. Transmission electron microscopy, atomic force small-angle X-ray scattering studies indicated nanostructure's morphologies are responsive...
We developed three new analogs of the antimicrobial peptide (AMP) Citropin 1.1: DAN-1-13, AJP-1-1, and HHX-2-28, tested their potential antibiofilm activities against Staphylococcus aureus S. pseudintermedius. Potential cytotoxic or hemolytic effects were determined using cultured human keratinocytes erythrocytes to determine safety.