A5008399151- 3D Printing in Biomedical Research
- Cancer Cells and Metastasis
- Advanced Drug Delivery Systems
- Nanoparticle-Based Drug Delivery
- Drug Solubulity and Delivery Systems
- Innovative Microfluidic and Catalytic Techniques Innovation
- Proteoglycans and glycosaminoglycans research
- Glycosylation and Glycoproteins Research
- Cancer Research and Treatments
- Inhalation and Respiratory Drug Delivery
- Microfluidic and Capillary Electrophoresis Applications
- Infant Nutrition and Health
- Drug Transport and Resistance Mechanisms
- Cancer, Hypoxia, and Metabolism
- Single-cell and spatial transcriptomics
- Liver physiology and pathology
i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto
2020-2024
Universidade do Porto
2020-2024
University of Beira Interior
2018
Inflammatory bowel disease (IBD) encompasses a set of chronic inflammatory conditions, namely Crohn's and ulcerative colitis. Despite all advances in the management IBD, definitive cure is not available, largely due to lack holistic understanding its etiology pathophysiology. Several vitro, vivo, ex vivo models have been developed over past few decades order abbreviate remaining gaps. The establishment reliable predictable vitro intestinal inflammation may indeed provide valuable tools...
Abstract Inflammatory Bowel Disease (IBD) is a chronic inflammatory condition affecting the gastrointestinal tract (GIT). Glucagon‐like peptide‐2 (GLP‐2) analogs possess high potential in treatment of IBD by enhancing intestinal repair and attenuating inflammation. Due to enzymatic degradation poor absorption, GLP‐2 are administered parenterally, which leads patient compliance. This work aims develop IBD‐targeted nanoparticles (NPs) for oral delivery analog, Teduglutide (TED). Leveraging...
In vitro 3D cancer spheroids generally exhibit a drug resistance profile similar to that found in solid tumors. Due this property, these models are an appealing for anticancer compounds screening. Nevertheless, the techniques and methods aimed discovery mostly standardized cells cultured 2D. The development of 2D cell culture displaying resistant is required mimic vivo tumors, while equipment, techniques, methodologies established conventional cultures can continue be employed compound work,...