A5018425647- Electrospun Nanofibers in Biomedical Applications
- Tendon Structure and Treatment
- 3D Printing in Biomedical Research
- Tissue Engineering and Regenerative Medicine
- Cellular Mechanics and Interactions
- Plant biochemistry and biosynthesis
- Natural product bioactivities and synthesis
- Periodontal Regeneration and Treatments
- Additive Manufacturing and 3D Printing Technologies
- Laser Applications in Dentistry and Medicine
- Shoulder Injury and Treatment
- Hydrogels: synthesis, properties, applications
- Advanced Cellulose Research Studies
- Bone Tissue Engineering Materials
- Extracellular vesicles in disease
- Silk-based biomaterials and applications
- Polysaccharides and Plant Cell Walls
- Orthopedic Surgery and Rehabilitation
- Essential Oils and Antimicrobial Activity
- Phase Equilibria and Thermodynamics
- Sports injuries and prevention
- Innovative Microfluidic and Catalytic Techniques Innovation
- Wound Healing and Treatments
- Hemostasis and retained surgical items
- Proteoglycans and glycosaminoglycans research
University of Minho
2015-2024
Hospital Braga
2023
Materials Research Group (United States)
2018
University of Aveiro
2008-2016
Injectable hyaluronic acid (HA)-based hydrogels compose a promising class of materials for tissue engineering and regenerative medicine applications. However, their limited mechanical properties restrict the potential range application. In this study, cellulose nanocrystals (CNCs) were employed as nanofillers in fully biobased strategy production reinforced HA nanocomposite hydrogels. Herein we report development new injectable composed adipic dihydrazide-modified (ADH-HA) aldehyde-modified...
Tendon and ligament (T/L) function is intrinsically related with their unique hierarchically anisotropically organized extracellular matrix. Their natural healing capacity is, however, limited. Here, continuous aligned electrospun nanofiber threads (CANT) based on synthetic/natural polymer blends mechanically reinforced cellulose nanocrystals are produced to replicate the nanoscale collagen fibrils grouped into microscale fibers that compose native T/L. CANT then incrementally assembled 3D...
Anisotropically aligned electrospun nanofibrous scaffolds based on natural/synthetic polymer blends have been established as a reasonable compromise between biological and biomechanical performance for tendon tissue engineering (TE) strategies. However, the limited tensile properties of these biomaterials restrict their application in this field due to load‐bearing nature tendon/ligament tissues. Herein, use cellulose nanocrystals (CNCs) reinforcing nanofillers blend matrix,...
Topographical cues of magnetically responsive tendon mimetic 3D scaffolds in combination with magneto-mechanical stimulation human adipose stem cells synergistically boost their tenogenesis.
Abstract Growth factors (GFs) are proteins secreted by cells that regulate a variety of biological processes. Although they have long been proposed as potent therapeutic agents, their administration in soluble form has proven costly and ineffective due to short half‐lives environments. Biomaterial‐based approaches increasingly sought alternatives improve the efficacy or, ideally, replace need for exogenous GFs regenerative medicine strategies. The means which these systems evolve from...
Molecular imprinting (MI) has been explored as an increasingly viable tool for molecular recognition in various fields. However, of biologically relevant molecules like proteins is severely hampered by several problems. Inspired natural antibodies, the use epitopes templates to circumvent those limitations, offering lower costs and greater versatility. Here, we review latest innovations this technology, well different applications where MI polymers (MIPs) have used target biomolecules...
Abstract Recreating the extracellular matrix organization and cellular patterns of anisotropic tissues in bioengineered constructs remains a significant biofabrication challenge. Magnetically‐assisted 3D bioprinting strategies can be exploited to fabricate biomimetic scaffolding systems, but they fail provide control over distribution magnetic materials incorporated bioinks while preserving fidelity designed composites. To overcome this dichotomy, concepts magnetically‐ matrix‐assisted are...
Abstract Several millions of individuals are estimated to develop post-acute sequelae SARS-CoV-2 condition (PASC) that persists for months after infection. Here we evaluate the immune response in convalescent with PASC compared asymptomatic and uninfected participants, six following their COVID-19 diagnosis. Both cases characterised by higher CD8 + T cell percentages, however, proportion blood cells expressing mucosal homing receptor β7 is low patients. show increased expression PD-1,...
Injectable hydrogels are particularly interesting for applications in minimally invasive tissue engineering and regenerative medicine strategies. However, the typical isotropic microstructure of these biomaterials limits their potential regeneration ordered tissues. In present work, we decorated rod-shaped cellulose nanocrystals with magnetic nanoparticles coated polydopamine polyethylene glycol polymer brushes to obtain chemical colloidal stable nanoparticles. Then, (0.1–0.5 wt %) were...
Three-dimensional (3D) bioprinting holds the promise to fabricate tissue and organ substitutes for regenerative medicine. However, lack of bioactive inks support functional living constructs is one main limitations hindering progress this technology. In study, a biofunctional human-based nanocomposite bioink (HUink) composed platelet lysate hydrogels reinforced by cellulose nanocrystals reported. When combined with suspended technologies, HUink allows biofabrication 3D freeform high...
This review aims to provide an overview of the biogenetic origin triterpenic acids (with particular emphasis on ursolic, oleanolic and betulinic acids), analytical extraction hyphenated methodologies (mainly GC-MS) used their identification quantification, followed by major sources these components, indicating potential large scale production pathways, with especial abundant agroforestry biomass residues. The biological activity is described, focusing antitumoral as modulators growth...
The innate graded structural and compositional profile of musculoskeletal tissue interfaces is disrupted replaced by fibrotic in the context disease degeneration. Tissue engineering strategies focused on restoration transitional complexity found those junctions present special relevance for regenerative medicine. Herein, we developed a gelatin-based multiphasic hydrogel system, where sections with distinct composition microstructure were integrated single unit. In each phase, hydroxyapatite...