A5068151285- Drug Solubulity and Delivery Systems
- Advanced Drug Delivery Systems
- Inhalation and Respiratory Drug Delivery
- Advancements in Transdermal Drug Delivery
- Analytical Methods in Pharmaceuticals
- Analytical Chemistry and Chromatography
- Microencapsulation and Drying Processes
- Academic Research in Diverse Fields
- Computational Drug Discovery Methods
- Cancer therapeutics and mechanisms
- Cholinesterase and Neurodegenerative Diseases
- Nanoparticle-Based Drug Delivery
- Synthesis and biological activity
- Chemical Synthesis and Reactions
- Intramuscular injections and effects
- Crystallization and Solubility Studies
- Antibiotics Pharmacokinetics and Efficacy
- Silymarin and Mushroom Poisoning
- Vascular Malformations and Hemangiomas
- Biotechnology and Related Fields
- Chemical Reactions and Isotopes
- Mesoporous Materials and Catalysis
- Facial Rejuvenation and Surgery Techniques
- Neutropenia and Cancer Infections
- Characterization and Applications of Magnetic Nanoparticles
Universidade Federal do Rio de Janeiro
2013-2024
Trinity College Dublin
2015-2016
Johns Hopkins Medicine
1974
Johns Hopkins University
1974
In the present study, in vitro permeation experiments a Franz diffusion cell were performed using different synthetic polymeric membranes and pig ear skin to evaluate rivastigmine (RV) transdermal drug delivery system. vitro-in vivo correlations (IVIVC) examined determine best model membrane. studies across for Exelon® Patch (which contains RV), results compared. Deconvolution of bioavailability data Wagner–Nelson method enabled fraction RV absorbed be determined point-to-point IVIVC...
The purpose of this study was to prepare engineered particles rivastigmine hydrogen tartrate (RHT) and characterize the physicochemical aerodynamic properties, in comparison a lactose carrier formulation (LCF). Microparticles were prepared from ethanol/water solutions containing RHT with without incorporation l-leucine (Leu), using spray dryer. Dry powder inhaler formulations characterized by scanning electron microscopy, X-ray diffraction, laser diffraction particle sizing, ATR-FTIR,...
Thiosemicarbazone-acridine hybrids are prominent inhibitors of topoisomerases II. This study reports the design, synthesis, and antiproliferative evaluation eighteen new acridine–thiosemicarbazone derivatives as possible topoisomerase IIα. In general, compounds showed moderate to low cytotoxicity in first screening performed on three cell lines, with emphasis DT-3OCH3 series, which five six have been active. Further studies against resistant leukemic cells indicated an interesting profile...
In this study, we report the synthesis of twenty new acridine-thiosemicarbazone derivatives and their antiproliferative activities. Mechanisms action such as inhibition topoisomerase IIα interaction with DNA have been studied for some most active by means both in silico vitro methods, evaluations non-clinical toxicities (in vivo) mice. general, compounds showed greater cytotoxicity against B16-F10 cells, highest potency DL-08 (IC50 = 14.79 µM). Derivatives DL-01 (77%), DL-07 (74%) (79%)...
Abstract Rivaroxaban (RXB), an oral direct factor Xa inhibitor, presents innovative therapeutic profile. However, RXB has shown adverse effects, mainly due to pharmacokinetic limitations, highlighting the importance of developing more effective formulations. Therefore, this work aims at preparation, physicochemical characterization and in vitro evaluation time-dependent anticoagulant activity toxicology profile RXB-loaded poly(lactic- co -glycolic acid) (PLGA)/poloxamer nanoparticles...
Bacterial infections represent one of the leading causes mortality in world. Among causative pathogens, S. aureus is prominently known as underlying cause many multidrug resistant that are often treated with first-line choice antibiotic vancomycin (VCM). Loading antibiotics into polymeric nanoparticles (Np) displays promise an alternative method to deliver therapy due greater access and accumulation at site infection well reducing toxicity, irritation degradation. The aim this work was...
In this study we aimed to develop a roflumilast (R) and formoterol fumarate (F) dry powder inhaler formulation (DPI) incorporating HPβCD by spray drying evaluated if it attenuates the inflammatory process improves lung function in murine model of ovalbumin induced allergic asthma. The DPI was characterized X-ray diffraction, thermal analysis, scanning electron microscopy, particle size, density, specific surface area dynamic vapor sorption analyses. vitro deposition studies were performed...
Silybin (SIB) is a hepatoprotective drug known for its poor oral bioavailability, attributed to classification as class IV with significant metabolism during the first-pass effect. This study explored potential of solid lipid nanoparticles (SLN-SIB-U) or without (SLN-SIB) ursodeoxycholic acid and polymeric (PN-SIB) delivery systems SIB. The efficacy these nanosystems was assessed through in vitro studies using GRX Caco-2 cell lines permeability proliferation assays, respectively, well vivo...
Metformin is a euglycemic drug for the treatment of type 2 diabetes mellitus. To date, there are 13 dissolution methodologies described in U.S. Pharmacopoeia (USP) to evaluate release profile metformin from extended-release tablets utilizing either USP apparatus 1 (basket) or (paddle). In absence protocol 3 (reciprocating cylinder), goal this work was develop an vitro method based on vivo–in correlation (IVIVC). Following systematic evaluation, final method, M4, defined. It applied 30 dips...
Abstract Injectable solutions containing epinephrine (EPI) and norepinephrine (NE) are not stable, their degradation is favored mainly by the oxidation of catechol moiety. As studies these drugs under forced conditions scarce, herein, we report identification products (DP) in anesthetic formulations development stability‐indicating HPLC method. Finally, risk assessment major was evaluated using silico toxicity approach. method developed to obtain a higher selectivity allowing adequate...
Abstract Objective The objective of this work was to develop a self‐emulsifying drug delivery system (SEDDS) containing caffeine for the treatment cellulite. Methods SEDDS were prepared using solution method. 0.5% (w/v) added previously selected excipients. characterized by droplet size, zeta potential, emulsification time and long‐term stability. In vitro release skin permeation investigated Franz‐type diffusion cells. cytotoxicity evaluated on normal human keratinocytes. Results Caffeine...
Background: Oral suspensions are heterogeneous disperse systems, and the particle size distribution, crystalline form of dispersed solid, composition formulation can be listed as parameters that control drug dissolution rate its bioavailability. Objective: The aim this work was to develop a discriminative test, which, in association with silico methodologies, make it possible safely anticipate bioavailability problems. Methods: Nimesulide ibuprofen (BCS class II) cephalexin I) oral were...
INJECTABLE SUSPENSION.A reversed-phase HPLC method was developed and validated to separate simultaneously quantify the association of betamethasone sodium phosphate (BP) dipropionate (BD) in injectable suspensions.Chromatographic conditions were ternary gradient elution at 1.6 mL/min on a C18 column with 254 nm.The linearity established range 120 280 mg/mL BD, 48 112 BP.The RSD intermediate precision <1% recoveries 99-101% for both drugs.The proved selective, linear, precise, accurate robust...
Introduction: Thrombotic disorders are among the leading causes of morbidity and mortality worldwide. Drugs used in prevention treatment atherothrombosis have pharmacokinetic limitations adverse effects such as hemorrhagic conditions, highlighting importance developing more effective antiplatelet agents. Methods: In this work, we synthesized N,N'-disubstituted ureas 3a-3j evaluated their profiles through vitro, ex vivo, silico studies. Results: The derivatives exhibited a selective...