A5055022776- Advanced Drug Delivery Systems
- Nanoparticle-Based Drug Delivery
- Drug Solubulity and Delivery Systems
- Lipid Membrane Structure and Behavior
- Drug Transport and Resistance Mechanisms
- RNA Interference and Gene Delivery
- 3D Printing in Biomedical Research
- Advancements in Transdermal Drug Delivery
- Barrier Structure and Function Studies
- Cancer Cells and Metastasis
- Curcumin's Biomedical Applications
- Polymer Surface Interaction Studies
- Nuts composition and effects
- Electrospun Nanofibers in Biomedical Applications
- Cancer Research and Treatments
- Spectroscopy and Quantum Chemical Studies
- Phytochemicals and Antioxidant Activities
- Glycosylation and Glycoproteins Research
- Proteoglycans and glycosaminoglycans research
- Dendrimers and Hyperbranched Polymers
- Stalking, Cyberstalking, and Harassment
- Plant biochemistry and biosynthesis
- Bullying, Victimization, and Aggression
- Linguistics and Language Studies
- Youth, Politics, and Society
Rede de Química e Tecnologia
2022-2023
Polytechnic Institute of Porto
2022-2023
Universidade do Porto
2016-2022
i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto
2016-2022
Instituto Superior de Engenharia do Porto
2022
Cooperativa de Ensino Superior Politécnico e Universitário
2018-2021
Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde
2018-2021
Instituto Português de Oncologia Francisco Gentil
2013
University of Aveiro
2013
Little is known on the expression of tumour‐associated carbohydrate antigen sialyl‐Tn (STn), in bladder cancer. We report here that 75% high‐grade tumours, presenting elevated proliferation rates and high risk recurrence/progression expressed STn. However, it was mainly found non‐proliferative areas tumour, namely cells invading basal muscle layers. STn also tumour‐adjacent mucosa, which suggests its dependence a field effect tumour. Furthermore, not by normal urothelium, demonstrating...
From a patient-centric perspective, oromucosal drug delivery is highly attractive due to the ease of administration without need swallowing, and improved patient safety. The aim presented work was prepare buccal film using self-forming micellar solubiliser as matrix, combining it with mucoadhesive polymer for an enhanced retention on mucosa. Specifically, we propose use graft co-polymer (Soluplus®), former, supplemented polymers more hydrophilic properties known properties; hydroxypropyl...
This work addresses the establishment and characterization of gellan gum:pectin (GG:P) biodegradable mucoadhesive beads intended for colon-targeted delivery resveratrol (RES). The impact polymer carrier system on cytotoxicity permeability RES was evaluated. Beads circular shape (circularity index 0.81) with an average diameter 914 μm, Span 0.29, entrapment efficiency 76% were developed. In vitro drug release demonstrated that able to reduce rates in gastric media control up 48 h at...
Nanoparticles based on gellan gum/pectin blends were designed for colon-targeted release of resveratrol (RES). Their impact drug rates and permeability evaluated using Caco-2 cell model mucus secreting triple co-culture model. Polymeric nanoparticles (PNP) successfully prepared by nebulization/ionotropic gelation, achieving high loading (>80%). PNP spherical with a low positive charge density (+5mV) exhibited diameters around 330 nm. Developed able to promote effective modulation rates, so...
Colorectal cancer (CRC) is a heterogeneous disease with high incidence and mortality worldwide. The efficacy of conventional CRC chemotherapy hampered by poor drug solubility bioavailability suboptimal pharmacokinetic profiles. In this work, camptothecin (CPT), potent anticancer drug, was loaded into an amphiphilic chitosan modified PEG oleic acid, to reduce progression after oral administration. While CPT-loaded micelles presented activity against HCT116, Caco-2 HT29 cell lines in vitro,...
<ns4:p>This study addresses the critical issue of stroke, a leading cause mortality and disability in Portugal, by implementing comprehensive educational intervention among 10th-grade students. The Via Verde AVC (VVAVC) fast track protocols underscore urgency early stroke recognition, emphasizing pivotal role timely responses pre-hospital emergency situations. project, involving 458 students, demonstrates substantial improvement knowledge post-intervention, with 88% students recognizing...
Chestnut (Castanea sativa) shells (CSS) are a source of bioactive compounds with well demonstrated in-vitro antioxidant properties. Nevertheless, no in-vivo studies have already evaluated this effect. This study the effects oral daily administration an eco-friendly CSS extract (50 and 100 mg/kg per body weight (b.w.)) to rats regarding activity, glucose lipids levels, metabolomic profiling polyphenols by LC-ESI-LTQ-Orbitrap-MS. The results properties in animals liver, kidney blood serum, as...
The present study attempted for the first time to explore effects of daily oral intake a phenolics-rich extract from chestnut shells (CS) on metabolomic profiling rat tissues by liquid chromatography coupled Orbitrap-mass spectrometry (LC-ESI-LTQ-Orbitrap-MS) targeted polyphenolics and their metabolites screen potential oxidative stress biomarkers, validating its use as promising nutraceutical ingredient with outstanding antioxidant properties prevention co-therapy lifestyle-related diseases...
The oral route is widely accepted as the most physiological path for exogenous administration of insulin, it closely mimic endogenous insulin pathway. Thus, in this work proposed an innovative lipid-polymeric nanocarrier to delivery orally. Areas covered: Nanoparticles were produced through a modified solvent emulsification-evaporation method, using ethyl palmitate and hydroxypropylmethylcellulose acetate succinate matrix. Lipid-polymeric nanoparticles around 300 nm size, negatively charged...
Aim: Explore the use of polymeric micelles in development powders intended for pulmonary delivery biopharmaceuticals, using insulin as a model protein. Materials & methods: Formulations were assessed vitro aerosolization properties and vivo efficacy safety streptozotocin-induced diabetic rat model. Results: Powders presented good like fine particle fraction superior to 40% mass median aerodynamic diameter inferior 6 μm. Endotracheally instilled have shown faster onset action than...
Herpetic infections caused by Herpes simplex virus (HSV) are among the most common human infections, affecting more than two quarters of world's population. The standard treatment for orofacial herpes is administration antiviral drugs, mainly acyclovir (ACV). However, current products mostly based on semisolid formulations that have limited ability to promote drug skin penetration and tend leak from application site, thus showing reduced sustain local residence. This work reports production...