A5041268623- Advanced Drug Delivery Systems
- Analytical Chemistry and Chromatography
- Polymer Foaming and Composites
- Injection Molding Process and Properties
- Surfactants and Colloidal Systems
- Nanoparticle-Based Drug Delivery
- Phytochemistry and Bioactivity Studies
- Ginseng Biological Effects and Applications
- Biochemical Analysis and Sensing Techniques
- Antifungal resistance and susceptibility
- Oral and gingival health research
- Oral microbiology and periodontitis research
- Phase Equilibria and Thermodynamics
- Carbohydrate Chemistry and Synthesis
- Pharmacological Effects of Natural Compounds
University of Oslo
2018-2020
University of Cambridge
2015
In this study, self-assembling Soluplus® micelles were examined for inherent properties. Through calorimetric analysis, the critical micelle concentration (CMC) could be determined at 25 and 37 °C, influence of three media (Milli-Q water, phosphate-buffered saline (PBS) with a pH 7.4 0.1 M HCl) on lower solution temperature (LCST) was detected. Furthermore, solubilisation poorly soluble drug, furosemide, into studied. The concentration-dependent properties micellar system assessed through an...
From a patient-centric perspective, oromucosal drug delivery is highly attractive due to the ease of administration without need swallowing, and improved patient safety. The aim presented work was prepare buccal film using self-forming micellar solubiliser as matrix, combining it with mucoadhesive polymer for an enhanced retention on mucosa. Specifically, we propose use graft co-polymer (Soluplus®), former, supplemented polymers more hydrophilic properties known properties; hydroxypropyl...
The present study is aimed to enhance the oral bioavailability of ketoprofen by inserting it into matrix poly(vinylpyrrolidone) (PVP) K10 spatially confined microcontainers, means supercritical CO2-aided impregnation. Microcontainers are cylindrical reservoirs, with typical sizes in micrometer range, a cavity open on one side, where drug formulation loaded. Differently traditional tablets, microcontainers have higher surface area per unit volume, and release only direction. This design meant...
Oral candidiasis is an important opportunistic fungal infection and polyenes azoles are still the most used antifungal agents. However, oral absorption resulting from available treatments generally poor and, consequently, a very high frequency of administrations agents strongly required. Therefore, major challenge to improve retention in buccal mucosa, encapsulation into mucoadhesive systems may be considered as possible strategy achieve this objective. Three types polymeric nanoparticles...
Glycyrrhiza glabra L. is considered an important source of bioactive compounds. This study aimed at the development efficient solution for treatment oral candidiasis. Several extracts were prepared using different solvents and their potential in vitro antifungal activity was assessed. Ethanolic showed most promising results against C. albicans. extract incorporated into mucoadhesive nanoparticles (PLA, PLGA alginate), which further included gel, film a toothpaste, respectively. The that...
The goal for any formulation design of poorly soluble drugs is to increase the solubility. However, increased solubility a challenge when drug administered oral cavity as rapidly dispersing or mucoadhesive buccal films. Most are bitter and may correlate with perceived worsening taste profile. aim present work was investigate dual effect inclusion complex formation, namely solubilization two lipophilic model (indomethacin furosemide) in hydrophobic hydroxypropyl-β-cyclodextrin increasing...