A5079400958- Advanced Drug Delivery Systems
- Advancements in Transdermal Drug Delivery
- Lipid Membrane Structure and Behavior
- RNA Interference and Gene Delivery
- Reproductive tract infections research
- Nanoparticle-Based Drug Delivery
- Wound Healing and Treatments
- Drug Solubulity and Delivery Systems
- Reproductive System and Pregnancy
- Dermatology and Skin Diseases
- Advanced biosensing and bioanalysis techniques
- Ocular Surface and Contact Lens
- Antimicrobial Peptides and Activities
- Antimicrobial agents and applications
- Bacterial biofilms and quorum sensing
- Surfactants and Colloidal Systems
- Curcumin's Biomedical Applications
- Advanced Fluorescence Microscopy Techniques
- Inhalation and Respiratory Drug Delivery
- Near-Field Optical Microscopy
- Urinary Tract Infections Management
- Digital Holography and Microscopy
- Electrospun Nanofibers in Biomedical Applications
- Preterm Birth and Chorioamnionitis
- Natural Antidiabetic Agents Studies
UiT The Arctic University of Norway
2016-2025
Centre for Arctic Gas Hydrate, Environment and Climate
2024
Pokhara University
2005-2011
Tohoku Medical and Pharmaceutical University
2000-2002
University of Zagreb
1992-2001
University of Freiburg
1998-2000
University of London
1995-1998
Abstract The texture properties of formulation are an important parameter in optimization topical formulations. These will affect applicability the at administration site and therapy outcome. Our aim was to develop a fast reliable method characterize hydrogels, namely cohesiveness, adhesiveness, hardness. During development, we realized that measurements setup needed be adjusted for each hydrogel type, Carbopol, chitosan, poloxamer hydrogels. influence polymer concentration, pH,...
Development of liposomal mucoadhesive drug delivery system, which is able to improve the bioavailability poorly absorbed oral drugs by prolonging their gastric and intestinal residence time, through facilitating intimate contact system with absorption membrane.Liposomes containing model atenolol were prepared modified ethanol injection method. Liposomes coated different polymers, for example, chitosan, Carbopol 974P, Eudragit L100, S100, optimize choice coating material. The systems tested...
Enterococcus faecium is a commensal but also bacteremia causing pathogen, which inherently resistant to several antimicrobials and has great ability acquire new traits. Bacterial membrane vesicles (MVs) are increasingly recognized as mode of cell-free communication way deliver virulence factors and/or antimicrobial resistance determinants. These features make MVs interesting research targets in on critical hospital pathogens. This study describes for the first time that E. strains produce...
Successful treatment of skin infections requires eradication biofilms found in up to 90 % all chronic wounds, causing delayed healing and increased morbidity. We hypothesized that chitosan hydrogel boosts the activity liposomally-associated membrane active antimicrobials (MAA) could potentially improve bacterial biofilm eradication. Therefore, liposomes (∼300 nm) bearing chlorhexidine (CHX; ∼50 μg/mg lipid) as a model MAA were incorporated into hydrogel. The novel CHX-liposomes-in-hydrogel...
Lecithin liposomes, empty or containing FITC-dextran, were prepared by the ethanol injection method. Three different types of chitosans with molecular weight and degrees deacetylation used (Seacure 113, 210 311). Chitosan coating was carried out mixing liposomal suspension chitosan solution followed incubation. The size liposomes measured before after polymer an image analysis technique. mean diameter FITC-dextran in range 250-280 nm, whereas 300-330 regardless type. All chitosan-coated...
Chitosan is currently proposed to be one of the most promising polymers in wound dressing development. Our research focuses on its potential as a vehicle for nano-delivery systems destined burn therapy. One important features bioadhesion wounded site. We compared bioadhesive properties chitosan with those Carbopol, synthetic origin polymer. Chitosan-based hydrogels different molecular weights were first analyzed by texture analysis gel cohesiveness, adhesiveness and hardness. In vitro...
Deformable propylene glycol-containing liposomes (DPGLs) incorporating metronidazole or clotrimazole were prepared and evaluated as an efficient drug delivery system to improve the treatment of vaginal microbial infections. The liposome formulations optimized based on sufficient trapping efficiencies for both drugs membrane elasticity a prerequisite successful permeability therapy. An appropriate viscosity administration was achieved by into Carbopol hydrogel. DPGLs able penetrate through...
From a patient-centric perspective, oromucosal drug delivery is highly attractive due to the ease of administration without need swallowing, and improved patient safety. The aim presented work was prepare buccal film using self-forming micellar solubiliser as matrix, combining it with mucoadhesive polymer for an enhanced retention on mucosa. Specifically, we propose use graft co-polymer (Soluplus®), former, supplemented polymers more hydrophilic properties known properties; hydroxypropyl...
A liposomes-in-hydrogel system as an advanced wound dressing for dermal delivery of curcumin was proposed improved chronic therapy. Curcumin, a multitargeting poorly soluble active substance with known beneficial properties healing, incorporated in deformable liposomes to overcome its poor solubility. Chitosan hydrogel served vehicle providing superior healing properties. The novel should assure sustained skin curcumin, and increase retention at the site, utilizing both chitosan improve...