A5067584346- Glioma Diagnosis and Treatment
- Electrospun Nanofibers in Biomedical Applications
- Cancer Cells and Metastasis
- Tissue Engineering and Regenerative Medicine
- Bone Tissue Engineering Materials
- MicroRNA in disease regulation
- Nanoplatforms for cancer theranostics
- Congenital heart defects research
- Nanoparticle-Based Drug Delivery
- Advanced biosensing and bioanalysis techniques
- Wnt/β-catenin signaling in development and cancer
- Mesenchymal stem cell research
- RNA Interference and Gene Delivery
- Antimicrobial agents and applications
- Cancer-related gene regulation
- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- RNA Research and Splicing
- Epigenetics and DNA Methylation
- TGF-β signaling in diseases
- Photodynamic Therapy Research Studies
- Protein Hydrolysis and Bioactive Peptides
- Immune cells in cancer
- Graphene and Nanomaterials Applications
- Biosensors and Analytical Detection
University of Minho
2015-2024
Instituto Nacional de Investigação Agrária e Veterinária
2024
Abstract One strategy to decrease the incidence of hospital-acquired infections is avoid survival pathogens in environment by development surfaces with antimicrobial activity. To study antibacterial behaviour active surfaces, different approaches have been developed which ISO 22916 standard. assess performance testing methodologies analyse activity hydrophobic surface patterned plastics as part a Horizon 2020 European research project. Four methods were used film, including standard,...
Glioblastoma (GBM), the most malignant primary brain tumor, leads to poor and unpredictable clinical outcomes. Recent studies showed tumor microenvironment has a critical role in regulating growth by establishing complex network of interactions with cells. In this context, we investigated how GBM cells modulate resident glial cells, particularly their paracrine activity, modulation can influence back on phenotype Conditioned media (CM) mouse cultures unexposed (unprimed) or exposed (primed)...
Glioblastoma (GBM) is a highly aggressive primary brain cancer, for which curative therapies are not available. An emerging therapeutic approach suggested to have potential target malignant gliomas has been based on the use of multipotent mesenchymal stem cells (MSCs), either unmodified or engineered deliver anticancer agents, as these present an intrinsic capacity migrate towards tumors. Nevertheless, it still controversial whether this innate tropism MSCs tumor area associated with cancer...
Background: Glioblastomas (GBMs) present remarkable metabolism reprograming, in which many cells display the “Warburg effect”, with production of high levels lactate that are extruded to tumour microenvironment by monocarboxylate transporters (MCTs). We described previously MCT1 is up-regulated human GBM samples, and inhibition decreases glioma cell viability aggressiveness. In study, we aimed unveil role prognosis explore it as a target for therapy vivo. Methods: activity protein expression...
Glioblastoma (GBM) is a universally fatal brain cancer, for which novel therapies targeting specific underlying oncogenic events are urgently needed. While the WNT pathway has been shown to be frequently activated in GBM, constituting potential therapeutic target, relevance of WNT6, an activator this pathway, remains unknown. Methods: WNT6 protein and mRNA levels were evaluated GBM. silenced or overexpressed GBM cells assess functional effects vitro vivo. Phospho-kinase arrays TCF/LEF...
Although some placenta-derived products are already used for tissue regeneration, the human chorion membrane (HCM) alone has been poorly explored. In fact, just one study uses decellularized HCM (dHCM) with native architecture (i.e., without extracellular matrix (ECM) suspension creation) as a substrate cell differentiation. The aim of this work is to fully characterize dHCM presence and distribution nuclei, DNA ECM components. Moreover, mechanical properties, in vitro biological performance...
In this work, polymer nanocomposite films based on poly(L-lactic acid) (PLLA) were reinforced with mesoporous silica nanoparticles, cellular foam (MCF) and Santa Barbara amorphous-15 (SBA). PLLA is a biobased aliphatic polyester, that possesses excellent thermomechanical properties, has already been commercialized for packaging applications. The aim was to utilize nanoparticles have established as nanocarriers enhance the mechanical thermal properties of PLLA. Since introduction...
Glioblastoma (GBM) is the most common and deadly primary malignant brain tumor. Current therapies are not effective, average survival of GBM patients after diagnosis being limited to few months. Therefore, discovery new treatments for this highly aggressive cancer urgently needed. Chalcones synthetic naturally occurring compounds that have been widely investigated as anticancer agents. In work, three chalcone derivatives were tested regarding their inhibitory activity selectivity towards...
The long non-coding RNA HOX transcript antisense intergenic (HOTAIR) is associated with oncogenic features in bladder cancer and predictive of poor clinical outcomes patients diagnosed this disease. In study, we evaluated the impact HOTAIR single nucleotide polymorphisms rs920778 rs12826786 on risk survival. This case-control study included 106 199 cancer-free controls. Polymorphisms were through PCR-restriction fragment length polymorphism. odds ratio 95% confidence intervals tested using...
spp. is among the most central etiological agents in foodborne bacterial disorders. To identify
Glioblastoma (GBM) is the most lethal and common malignant primary brain tumor in adults. An important feature that supports GBM aggressiveness unique composition of its extracellular matrix (ECM). Particularly, fibronectin plays an role cancer cell adhesion, differentiation, proliferation, chemoresistance. Thus, herein, a hydrogel with mechanical properties compatible ability to disrupt dynamic reciprocal interaction between cells was produced. High-molecular-weight hyaluronic acid (HMW-HA)...
Transforming growth factor beta (TGF-β) plays an important role in carcinogenesis. Two polymorphisms the TGF-β1 gene (-509C/T and 869T/C) were described to influence susceptibility gastric breast cancers. The 869T/C polymorphism was also associated with overall survival cancer patients. In present study, we investigated relevance of these glioma risk prognosis. A case-control study that included 114 patients 138 cancer-free controls performed. Single nucleotide (SNPs) evaluated by polymerase...
The increase of both arterial occlusive diseases and coronary heart leads to a higher demand for small-diameter vascular grafts (<6 mm). gold standard vessel replacement is the use autologous veins. Nevertheless, up 30% these patients need grafts. Although synthetic polymers have been successfully used large-diameter (>6 mm), they are associated with thrombosis, intimal hyperplasia, calcification, chronic inflammation when as Therefore, natural materials studied this application. In study,...
The identification of cancer stem cells (CSCs), which are implicated in tumor initiation, progression, therapy resistance, and relapse, is great biological clinical relevance. In glioblastoma (GBM), this still a challenge, as no single marker able to universally identify populations GBM (GSCs). Indeed, there controversy on whether biomarker-expressing fulfill the functional criteria bona fide GSCs, despite being widely used. Here, we describe novel subpopulation autofluorescent (Fluo+) that...
The existence of a clear association between stress and cancer is still matter debate. Recent studies suggest that chronic associated with some types may influence tumor initiation patient prognosis, but its role in brain tumors not known. Glioblastoma (GBM) highly malignant primary cancer, for which effective treatments do exist. Understanding how stress, or effector hormones glucocorticoids (GCs), modulate GBM aggressiveness great importance. To address this, we used both syngeneic...
Enterotoxigenic Escherichia coli (ETEC) is the major bacterial cause of diarrheal diseases in pigs, particularly at young ages, resulting significant costs to swine farming. The pathogenicity ETEC largely dependent on presence fimbriae and ability produce toxins. Fimbriae are responsible for their initial adhesion intestinal epithelial cells, leading onset infection. In particular, F4 type (K88) often attributed neonatal infections have also been associated with post-weaning infections. This...
According to the World Health Organization (WHO), chronic inflammatory-related diseases represent greatest threat human health. Indeed, failure in resolution of inflammation leads serious pathological conditions, such as cardiovascular diseases, arthritis, cancer, diabetes, autoimmune and neurodegenerative disorders that are often associated with extremely high suffering societal economic burdens. Despite number efficacy available therapeutic agents have been increased, side effects some...