A5076267258- Neonatal Respiratory Health Research
- Congenital Diaphragmatic Hernia Studies
- Pelvic floor disorders treatments
- Endometriosis Research and Treatment
- Maternal and Perinatal Health Interventions
- Uterine Myomas and Treatments
- Endometrial and Cervical Cancer Treatments
- Maternal Mental Health During Pregnancy and Postpartum
- Neuroscience of respiration and sleep
- Congenital Anomalies and Fetal Surgery
- Electrospun Nanofibers in Biomedical Applications
- Anorectal Disease Treatments and Outcomes
- Ovarian cancer diagnosis and treatment
- Maternal and fetal healthcare
- Reproductive Health and Contraception
- Urinary Bladder and Prostate Research
- Tissue Engineering and Regenerative Medicine
- Congenital heart defects research
- Cytokine Signaling Pathways and Interactions
- Sexual function and dysfunction studies
- Minimally Invasive Surgical Techniques
- Pregnancy and preeclampsia studies
- Congenital Heart Disease Studies
- Pregnancy-related medical research
- Cancer Risks and Factors
Hospital Braga
2015-2024
University of Minho
2015-2024
Ordem dos Médicos
2022
Ipca Laboratories (India)
2013-2015
Centro Hospitalar do Porto
2015
Medica (United States)
2014
Federación Colombiana de Obstetricia y Ginecología
2014
RMIT University
2006-2012
Hospital de São Marcos
2012
University of Oulu
2007
Although some placenta-derived products are already used for tissue regeneration, the human chorion membrane (HCM) alone has been poorly explored. In fact, just one study uses decellularized HCM (dHCM) with native architecture (i.e., without extracellular matrix (ECM) suspension creation) as a substrate cell differentiation. The aim of this work is to fully characterize dHCM presence and distribution nuclei, DNA ECM components. Moreover, mechanical properties, in vitro biological performance...
Vulvovaginal candidiasis (VVC) has been identified as a global issue of concern due to its clinical, social and economic implications. The emerging relevance VVC makes it crucial increase the knowledge on epidemiological etiological features in order improve prevention treatment. Thus, this study aimed reveal incidence, microbiology, antifungal pattern risk factors Portugal. For that, high vaginal samples were collected from 470 symptomatic asymptomatic participants; Candida spp. with...
The pathogenesis of pulmonary hypertension (PH) includes an inflammatory response. Thymulin, a zinc-dependent thymic hormone, has important immunobiological effects by inhibiting various proinflammatory cytokines and chemokines. We investigated morphological hemodynamic thymulin administration in rat model monocrotaline (MCT)-induced PH, as well the pattern cytokine gene expression intracellular pathways involved. Adult Wistar rats received injection MCT (60 mg/kg, sc) or equal volume...
Maternal depression and anxiety have been found to negatively affect fetal neonatal growth. However, the independent effects of maternal on fetal-neonatal growth outcomes trajectories remain unclear. This study aimed analyze simultaneously prenatal (1) outcomes, (2), trajectories, from 2nd trimester pregnancy childbirth.A sample 172 women was recruited completed self-reported measures during 3rd trimesters pregnancy, at childbirth. Fetal biometrical data were collected clinical reports same...
Antenatal stimulation of lung growth is a reasonable approach to treat congenital diaphragmatic hernia (CDH), disease characterized by pulmonary hypoplasia and hypertension. Several evidences from the literature demonstrated possible involvement renin-angiotensin system (RAS) during fetal development. Thus, expression pattern renin, angiotensin-converting enzyme, angiotensinogen, type 1 (AT1) 2 (AT2) receptors angiotensin II (ANGII) was assessed immunohistochemistry throughout gestation,...
Endometriosis Health Profile Questionnaire-30 is currently the most used questionnaire for quality of life measurement in women with endometriosis. The aim this study to evaluate psychometric properties and validate Portuguese version.A sequential sample 152 patients endometriosis, followed a Portugal reference center, were asked complete on social demographic features, version Short Form Survey 36 Item â 2. Appropriate statistical analysis was performed using descriptive statistics, factor...
Abstract Aging and testosterone almost inexorably cause benign prostatic hyperplasia (BPH) in Human males. However, etiology of BPH is largely unknown. Serotonin (5-HT) produced by neuroendocrine cells presents high concentration normal transition zone, but its function prostate physiology Previous evidence demonstrated that 5-HT are decreased compared to prostate. Here, we show a strong negative regulator growth. In vitro , inhibits rat branching through down-regulation androgen receptor...
Abstract Background Characterized by abnormal lung growth or maturation, congenital diaphragmatic hernia (CDH) affects 1:3000 live births. Cellular studies report proximal (SOX2 + ) and distal (SOX9 progenitor cells as key modulators of branching morphogenesis epithelial differentiation, whereas transcriptome demonstrate ROBO/SLIT potential therapeutic targets for diaphragm defect repair in CDH. In this study, we tested the hypothesis that (a) experimental-CDH could changes expression...
Background/Aims: The human embryo develops in a hypoxic environment. In this way, cells have to rely on the glycolytic pathway for energy supply, leading an intracellular accumulation of monocarboxylates such as lactate and pyruvate. These acids important role cell metabolism their rapid transport across plasma membrane is crucial maintenance pH homeostasis. This mediated by family transporters, designated monocarboxylate transporters (MCTs), namely isoforms 1 4. MCT1/4 expression regulated...
Background We aimed to determine the prevalence of vaginal colonization by Gardnerella vaginalis and bacterial vaginosis (BV) in Portuguese pregnant women, identify risk factors for BV G. pregnancy. Methods A cross-sectional study was conducted among women aged ≥ 18 years who were attending two public hospitals Northwest region Portugal. Epidemiological data collected anonymous questionnaire. diagnosed Nugent criteria presence identified polymerase chain reaction. Crude associations between...
Key points Retinoic acid (RA) and ghrelin levels are altered in human hypoplastic lungs when compared to healthy lungs. Although considerable data have been obtained about RA, bombesin the congenital diaphragmatic hernia (CDH) rat model, neuroendocrine factors never associated with RA signalling pathway this animal model. In study, interaction between was explored CDH The authors found that normal fetal lung explants treated showed an increase growth. Hypoplastic presented higher expression...
The glycoprotein 130 (gp130) dependent family of cytokines comprises interleukin-6 (IL-6), IL-11, leukemia inhibitory factor (LIF), cardiotrophin-like cytokine (CLC), ciliary neurotrophic (CNTF), cardiotrophin-1 (CT-1) and oncostatin M (OSM). These share the membrane gp130 as a common signal transducer. Recently, it was demonstrated that IL-6 promotes, whereas LIF inhibits fetal lung branching. Thus, in this study, effects on morphogenesis other classical members gp130-type (IL-11, CLC,...
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Background Leukemia inhibitory factor (LIF) and interleukin-6 (IL-6) are members of the family glycoprotein 130 (gp130)-type cytokines. These cytokines share gp130 as a common signal transducer, which explains why they show some functional redundancy. Recently, it was demonstrated that IL-6 promotes fetal lung branching. Additionally, LIF has been implicated in developmental processes branching organs. Thus, this study expression pattern its effects on rat morphogenesis were assessed....