A5086553535- Congenital Heart Disease Studies
- Congenital Diaphragmatic Hernia Studies
- Neonatal Respiratory Health Research
- Congenital Anomalies and Fetal Surgery
- Pulmonary Hypertension Research and Treatments
- Tracheal and airway disorders
- Venous Thromboembolism Diagnosis and Management
- Cardiovascular Conditions and Treatments
- Coronary Artery Anomalies
- Cardiac Arrest and Resuscitation
- Cardiac Valve Diseases and Treatments
- Regulation of Appetite and Obesity
- Vascular anomalies and interventions
- Medical Image Segmentation Techniques
- Vascular Malformations and Hemangiomas
- Vascular Anomalies and Treatments
- Kawasaki Disease and Coronary Complications
- Transplantation: Methods and Outcomes
- Cardiovascular Syncope and Autonomic Disorders
- Urological Disorders and Treatments
- Advanced MRI Techniques and Applications
- Ethics in Clinical Research
- Congenital heart defects research
- Mechanical Circulatory Support Devices
- Biomedical Ethics and Regulation
Universidade do Porto
2003-2025
Hospital de São João
2013-2025
Centro Hospitalar do Porto
2014-2020
University of Minho
2005-2019
Hospital Curry Cabral
2014
RMIT University
2006
Hospital Maria Pia
2002
Children’s Institute
2001-2002
Children's Hospital of Philadelphia
2001-2002
Johns Hopkins Medicine
2002
We investigated the endogenous production of ghrelin as well cardiac and pulmonary vascular effects its administration in a rat model monocrotaline (MCT)-induced hypertension (PH). Adult Wistar rats randomly received subcutaneous injection MCT (60 mg/kg) or an equal volume vehicle. One week later, animals were assigned to receive (100 μg/kg bid for 2 wk) saline. Four groups analyzed: normal treated with ( n = 7), injected saline 9), 9). At 22–25 days, right (RV) left ventricular (LV)...
Introduction International policy imperatives for the public and patient involvement in governance of health data coexist with conflicting cross-border policies on sharing. This can challenge planning implementation participatory healthcare services locally. Engaging local stakeholders understanding how their needs, values preferences governing be articulated made at supranational level is crucial. paper describes a protocol project that aims to coproduce people-centred model involving...
<i>Objective:</i> In congenital diaphragmatic hernia (CDH) the severity of pulmonary hypertension (PH) is considered, by several authors, determinant clinical outcome. Plasmatic N-terminal-pro-B type natriuretic peptide (NT-proBNP) might be useful in diagnosis and management PH newborns, although its interest CDH infants remains to defined. Early NT-proBNP levels were assessed correlated with cardiovascular echocardiographic parameters. <i>Patients Methods:</i> 28...
Parenchymal lung diseases are the main cause of persistent pulmonary hypertension newborn (PPHN). We aimed to assess non cardiac conditions associated PPHN in and survival rate over last 15 years, at our center. A retrospective chart review neonates admitted for from 1996 2010 was performed. New therapies were introduced 2003, rates between two periods (1996–2002 2003–2010) compared. Out 6750 newborns, 78 (1.1%) had diagnosis cause. The most prevalent causes hypoplasia (30.7%), infection...
Antenatal stimulation of lung growth is a reasonable approach to treat congenital diaphragmatic hernia (CDH), disease characterized by pulmonary hypoplasia and hypertension. Several evidences from the literature demonstrated possible involvement renin-angiotensin system (RAS) during fetal development. Thus, expression pattern renin, angiotensin-converting enzyme, angiotensinogen, type 1 (AT1) 2 (AT2) receptors angiotensin II (ANGII) was assessed immunohistochemistry throughout gestation,...
Pediatric pulmonary embolism (PE) is rare but associated with adverse outcomes. We aimed to characterize PE cases admitted in a tertiary hospital and evaluate sensitivity of selected diagnostic prediction tools.Retrospective, descriptive study from 2008 2020 using data collected records. Patients were grouped according severity setting (outpatients vs. inpatients). Links correlation demographic characteristics, risk factors, clinical presentation, management, outcomes analyzed. tools...
Abstract Dilated cardiomyopathy is the most common form of in paediatric population and an important cause heart transplantation children. The clinical profile course dilated children have been poorly characterised. A retrospective review 61 patients (37 female; 24 male) diagnosed with from January, 2005 to June, 2012 at a single institution was performed. median age diagnosis 15 months. Heart failure present 83.6% 44.3% required intensive care. prevalent causes were idiopathic (47.5%),...
Assessing public and patients' expectations concerns about genomic data sharing is essential to promote adequate governance engagement in rare diseases genomics research. This cross-sectional study compared the views of 159 disease patients, 478 informal carers 63 healthcare professionals Northern Portugal benefits risks for research, its associated factors. The three participant groups expressed significantly different views. majority patients (84.3%) (87.4%) selected discovery a cure...
Alveolar capillary dysplasia with misalignment of pulmonary veins (ACD/MPV) is a rare, fatal, neonatal developmental lung disorder, which usually presents as persistent hypertension unresponsive to treatment. The authors report the case neonate hypertension, associated duodenal stenosis secondary annular pancreas and intestinal malrotation. Support treatment, inhaled nitric oxide, oral sildenafil nebulized iloprost were used no clinical improvement. presented an overwhelming course,...
Congenital diaphragmatic hernia (CDH) is a life-threatening developmental anomaly, intrinsically combining severe pulmonary hypoplasia and hypertension. During development, signal transducers activators of transcription (STAT) are utilized to elicit cell growth, differentiation, survival.We used the nitrofen-induced CDH rat model. At selected gestational time points, lungs were divided into two experimental groups, i.e., control or CDH. We performed immunohistochemistry western blotting...
Aim: The aim of the study was to review our experience in management newborns with congenital diaphragmatic hernia (CDH). Methods: A retrospective including all infants CDH at Hospital de São João, a center that does not provide ECMO support, for period from 1997 2006. Since 2003, new treatment protocol has been used. Results: There were 61 (30 male/31 female) birth weight 2800 g (880 – 3770), and gestational age 38 weeks (28 41); 46 (75 %) inborn 42 (69 had prenatal diagnosis CDH. 2 (3...
Minimally invasive cardiovascular interventions guided by multiple imaging modalities are rapidly gaining clinical acceptance for the treatment of several diseases. These images typically fused with richly detailed pre-operative scans through registration techniques, enhancing intra-operative data and easing image-guided procedures. Nonetheless, rigid models have been used to align different modalities, not taking into account anatomical variations cardiac muscle throughout cycle. In current...