A5088564334- Glioma Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Hedgehog Signaling Pathway Studies
- Neurofibromatosis and Schwannoma Cases
- Cancer-related Molecular Pathways
- Genomics and Chromatin Dynamics
- Meningioma and schwannoma management
- DNA Repair Mechanisms
- Angiogenesis and VEGF in Cancer
- Cancer, Hypoxia, and Metabolism
- Microtubule and mitosis dynamics
- HER2/EGFR in Cancer Research
- Chromatin Remodeling and Cancer
- Neuroblastoma Research and Treatments
- MicroRNA in disease regulation
- Cancer Mechanisms and Therapy
- Cancer Genomics and Diagnostics
- Sarcoma Diagnosis and Treatment
- Molecular Biology Techniques and Applications
- Spinal Hematomas and Complications
- Genetics and Neurodevelopmental Disorders
- Monoclonal and Polyclonal Antibodies Research
- Vascular Malformations Diagnosis and Treatment
- Clinical Nutrition and Gastroenterology
- RNA modifications and cancer
Hospital de Câncer de Barretos
2013-2024
Universidade Federal do Triângulo Mineiro
2022
Hospital das Clínicas da Universidade Federal de Minas Gerais
2020
Hospital São Paulo
2010-2016
Hospital Universitario La Paz
2008
Instituto Barretos de Tecnologia
2004
Genomic analysis of a childhood cancer reveals markedly fewer mutations than what is typically seen in adult cancers.
Up to 20% of patients with pilocytic astrocytoma (PA) experience a poor outcome. BRAF alterations and Fibroblast growth factor receptor 1 ( FGFR1 ) point mutations are key molecular in Pas, but their clinical implications not established. We aimed determine the frequency prognostic role these cohort 69 PAs. assessed KIAA1549:BRAF fusion by fluorescence situ hybridization (exon 15) capillary sequencing. In addition, expression was analyzed using immunohistochemistry, this compared gene...
Glioblastoma ( GBM ), the most frequent and aggressive brain tumor, is characterized by marked angiogenesis directly related to invasiveness poor prognosis. Hypoxia considered be an important stimulus for inducing hypoxia‐inducible factor 1‐alpha HIF ‐1α) overexpression that activates platelet‐derived growth PDGF ) VEGF . The aim of this study analyze expression ‐ C , in endothelial tumor cells their relation ‐1α expression. Two hundred eight cases were studied tissue microarray...
Treatment for glioblastoma consists of radiotherapy and temozolomide-based chemotherapy. However, virtually all patients recur, leading to a fatal outcome. Receptor tyrosine kinase (RTK)-targeted therapy has been the focus attention in novel treatment options these patients. Here, we compared efficacy imatinib, sunitinib, cediranib models. In present work, biologic effect drugs was screened by viability, cell cycle, apoptosis, migration, invasion vitro assays or vivo chick chorioallantoic...
Human hotspot TERT promoter (TERTp) mutations have been reported in a wide range of tumours. Several studies shown that TERTp are associated with clinicopathological features; some instances, were considered as biomarkers poor prognosis. The rs2853669 SNP, located the region, was to modulate increased expression levels induced by recurrent somatic mutations. In this study we aimed determine frequency and prognostic value SNP 504 gliomas from Portuguese Brazilian patients. detected 47.8%...
The TP53 tumor suppressor gene codifies a protein responsible for preventing cells with genetic damage from growing and dividing by blocking cell growth or apoptosis pathways.A common single nucleotide polymorphism (SNP) in codon 72 (Arg72Pro) induces 15-fold decrease of apoptosis-inducing ability has been associated susceptibility to human cancers.Recently, another SNP at 47 (Pro47Ser) was reported have low apoptosis-208 ©FUNPEC-RP www.funpecrp.com.
Glioblastoma (GBM) is a universally fatal brain cancer, for which novel therapies targeting specific underlying oncogenic events are urgently needed. While the WNT pathway has been shown to be frequently activated in GBM, constituting potential therapeutic target, relevance of WNT6, an activator this pathway, remains unknown. Methods: WNT6 protein and mRNA levels were evaluated GBM. silenced or overexpressed GBM cells assess functional effects vitro vivo. Phospho-kinase arrays TCF/LEF...
Rosette-forming glioneuronal tumor (RGNT) of the IV ventricle is a rare and recently recognized brain entity. It histologically composed by two distinct features: glial component, resembling pilocytic astrocytoma, component forming neurocytic rosettes and/or perivascular rosettes. Herein, we describe 33-year-old man with RGNT arising in spinal cord. Following an immunohistochemistry validation, further performed extensive genomic analysis, using array-CGH (aCGH), whole exome cancer-related...
The 5’-methylthioadenosine phosphorylase (MTAP) gene is located in the chromosomal region 9p21. MTAP deletion a frequent event wide variety of human cancers; however, its biological role tumorigenesis remains unclear. purpose this study was to characterize expression profile series gliomas and associate it with patients’ clinicopathological features. Moreover, we sought evaluate, through glioma gene-edited cell lines, impact gliomas. evaluated 507 patients by immunohistochemistry (IHC),...
GBM may manifest rapidly de novo(primary GBM), or develop slowly from grade II orgrade III astrocytomas (secondary suggesting thatthey are distinct disease entities that evolve throughdifferent genetic pathways.In recent genome-wide analyses, high rates of sponta-neous mutations in the gene encoding cytosolic NADP-dependent isocitrate dehydrogenase 1 (IDH1) have beenreported diffuse gliomas including WHO grades andIII astroglial and oligodendroglial lineages.
The p53 tumor suppressor gene is the most frequently mutated in human cancer; this up to 50% of tumors.It has a critical role cell cycle, apoptosis and senescence, it participates many crucial physiological pathological processes.Polymorphisms have been suggested be associated with genetically determined susceptibility various types cancer.Another process involved ©FUNPEC-RP www.funpecrp.com.brGenetics Molecular Research 8 (1): 8-18 (2009) Polymorphisms methylation TP53 brain tumors...
XRCC1Arg194Trp and XRCC1Arg399Gln in gliomasXRCC1Arg194Trp polymorphism using PCR-RFLP 80 astrocytoma glioblastoma samples.Patients who had the allele Trp of an increased risk tumor development (OR = 8.80; confidence interval at 95% (95%CI) 4.37-17.70;P < 0.001), as did Gln 1.01; 95%CI 0.53-1.93;P 0.971).Comparison overall survival patients not show significant differences.We suggest that polymorphisms are involved susceptibility for developing astrocytomas glioblastomas.
XRCC3 and susceptibility to astrocytomas glioblastomas model.Patients who had the allele Met of Thr241Met polymorphism a significantly increased risk tumor development (odds ratio = 3.13; 95% confidence interval 1.50-6.50).There were no significant differences in overall survival patients.We suggest that is involved for developing glioblastomas.
OBJECTIVE: Report our experience with trigone ventricular meningiomas and review the surgical approaches to trigone. METHOD: From 1989 2006, six patients of lateral ventricles underwent microsurgical resection. Their clinical features, image, follow up, were retrospectively analyzed. RESULTS: Five presented large one small volume meningioma. Unspecific symptoms occurred in three patients; intracranial hypertension detected homonymous hemianopsy three; motor deficit present patient. Three...
The oncogene brachyury (TBXT) is a T-box transcription factor that overexpressed in multiple solid tumors and associated with tumor aggressiveness poor patient prognosis. Gliomas comprise the most common aggressive group of brain tumors, at present time functional clinical impact expression has not been investigated previously these neoplasms. Brachyury (mRNA protein) was assessed normal (n = 67), glioma tissues 716) cell lines 42), further silico studies were undertaken using genomic...
Glutathione S-transferases (GSTs) constitute a superfamily of ubiquitous multifunctional enzymes that are involved in the cellular detoxification large number endogenous and exogenous chemical agents have electrophilic functional groups.People who deficiencies this family genes at increased risk developing some types tumors.We examined GSTP1 Ile105Val polymorphism using PCR-RFLP 80 astrocytoma glioblastoma samples.Patients had Val allele an tumor development (odds ratio = 8.60; 95%...
Epidermal growth factor (EGF) plays an important role in cancer. A functional single nucleotide polymorphism (SNP) the 5'-untranslated region of EGF gene (+61 A>G) may influence its expression and contribute to cancer predisposition aggressiveness. Aiming investigate +61 A>G susceptibility glioma prognosis, we performed a case-control study with 165 patients 200 healthy controls from Brazil. Comparisons genotype distributions allele frequencies did not reveal any significant differences...
A retrospective study of 81 patients with low-grade astrocytoma (LGA) comparing the efficacy aggressive versus less surgery in eloquent and non-eloquent brain areas was conducted. Extent surgical resection analyzed to assess overall survival (OS) progression- free (PFS). Degree tumor classified as gross total (GTR), subtotal (STR) or biopsy. GTR, STR biopsy tumors were performed 31, 48 21% subjects, whereas resections 22.5, 35 42.5%. Overall 4.7 1.9 years submitted GTR/STR (p=0.013), among...
Copy number alterations (CNA) are one of the driving mechanisms glioma tumorigenesis, and currently used as important biomarkers in routine setting. Therefore, we performed CNA profiling 65 astrocytomas distinct malignant grades (WHO grade I-IV) Brazilian origin, using array-CGH microsatellite instability analysis (MSI), investigated their correlation with TERT IDH1 mutational status clinico-pathological features. Furthermore, silico Oncomine database was to validate our findings extend gene...
Purpose Central nervous system (CNS) malignant neoplasms may lead to venous thromboembolism (VTE) and bleeding, which result in rehospitalization, morbidity mortality. We aimed assess the incidence of VTE bleeding this population. Methods: This systematic review meta-analysis (PROSPERO CRD42023423949) were based on a standardized search PubMed, Virtual Health Library Cochrane (n = 1653) July 2023. After duplicate removal, data screening collection conducted by independent reviewers. The...
Epidermal growth factor (EGF) plays an important role in cancer. A functional single nucleotide polymorphism (SNP) the 5′-untranslated region of EGF gene (+61 A>G) may influence its expression and contribute to cancer predisposition aggressiveness. Aiming investigate +61 A>G susceptibility glioma prognosis, we performed a case-control study with 165 patients 200 healthy controls from Brazil. Comparisons genotype distributions allele frequencies did not reveal any significant...
<b><i>Background/Objectives:</i></b> Pilocytic astrocytomas (PAs) are the most frequent in children and adolescents. <i>Methilthioadenosine phosphorylase</i><i>(MTAP)</i> is a tumor-suppressor gene, loss of expression which associated with poor prognosis better response to specific chemotherapy leukemia non-small-cell lung cancer. The MTAP brain tumors remains largely unknown its biological role PA still unexplored. Our aims were describe...