A5000293296- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Nosocomial Infections in ICU
- Radiomics and Machine Learning in Medical Imaging
- Cancer Genomics and Diagnostics
- Pneumonia and Respiratory Infections
- Smoking Behavior and Cessation
- Neuroscience of respiration and sleep
- Cardiac Arrest and Resuscitation
- Obstructive Sleep Apnea Research
- Sepsis Diagnosis and Treatment
- Hemodynamic Monitoring and Therapy
- Diagnosis and treatment of tuberculosis
- Thermal Regulation in Medicine
- Respiratory Support and Mechanisms
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Research Studies
- Tuberculosis Research and Epidemiology
- Food Allergy and Anaphylaxis Research
- Cardiac Arrhythmias and Treatments
- Cervical Cancer and HPV Research
- Actinomycetales infections and treatment
- Eosinophilic Disorders and Syndromes
- Airway Management and Intubation Techniques
- Pleural and Pulmonary Diseases
IPO Porto
2024
University of Lisbon
2016-2024
Hospital Santo António dos Capuchos
2023
Hospitais da Universidade de Coimbra
2022
Hospital Prof. Dr. Fernando Fonseca
2014-2020
Hospital de São José
2011-2018
Hospital do Desterro
2018
Instituto Nacional del Tórax
2015
Universitat de Barcelona
2015
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2015
Introduction Despite the availability of new antibiotics such as daptomycin, methicillin-resistant Staphylococcus aureus (MRSA) bacteraemia continues to be associated with high clinical failure rates. Combination therapy has been proposed an alternative improve outcomes but there is a lack studies. The study aims demonstrate that combination daptomycin plus fosfomycin achieves higher success rates in treatment MRSA than alone. Methods and analysis A multicentre open-label, randomised phase...
Background: Ventilator-associated pneumonia (VAP) is associated to longer stay and poor outcomes. Lacking definitive diagnostic criteria, worsening gas exchange assessed by PaO2/FIO2 ≤ 240 in mmHg has been proposed as one of the criteria for VAP. We aim assess adequacy diagnose Methods: Prospective observational study 255 consecutive patients with suspected VAP, clustered according vs. > at onset. The primary analysis was association between quantitative microbiologic confirmation...
We report a case of primary cerebral abscess due to Nocardia asteroides in nonimmunocompromised patient with particular clinical course. The first symptom (right subacute brachial palsy) and the lesion computed tomographic (CT) scan (left parietofrontal edema suggestive brain tumor) disappeared after corticosteroid treatment was discharged total recovery. After 2 months she complained headache visual disturbance. A new CT showed an annular left occipital lobe. biopsy diagnosed nocardia...
other antibiotics.To our knowledge, this is the first case of KS with confirmed selective IgE-mediated allergy to cefazolin.
Immunotherapy has revolutionized the field of oncology by utilizing body's immune system to target and eliminate cancer cells. In non-small cell lung (NSCLC), immunotherapeutic agents such as checkpoint inhibitors (ICIs) have shown promising results. ICIs receptors like PD-1, PD-L1, CTLA-4 enhance response against tumors. However, resistance mechanisms immunotherapy are not fully understood, ongoing research aims overcome these challenges. early-stage setting, neoadjuvant adjuvant trials...
Introduction: Clinical guidelines recommend rapid evaluation of patients with suspected lung cancer. There are few data concerning delays in the diagnostic process cancer Portugal and adherence to recommendations. The aim this work is review analyze different phases diagnosis, staging, therapeutic decision treatment within a pulmonology department. Methods: Retrospective, single -center cohort study, identification analysis stages pathway taken by study contemplates flow design...
<b>Introduction:</b> Pulmonary sequestration represents 0,15-6% of all pulmonary malformations. The treatment is usually surgical (lobectomy). However, a less invasive approach with percutaneous embolization the systemic artery can be considered as an alternative option. <b>Methods:</b> Retrospective study last 13 years clinical cases in Radiology Department Lisbon. <b>Results:</b> 4 patients were identified (average age 34, 50% male). Concerning smoking habits, only one patient did not...
<b>Background:</b> electronic cigarette (e-cig) has emerged in recent years as an increasingly popular device. However, knowledge about its risks is growing and there are conflicting data to interest a smoking cessation aid. Public opinion on the subject varies greatly. <b>Objectives:</b> evaluate knowledge, perception of use e-cig adult smokers willing quit. <b>Methods:</b> cross-sectional prospective study recruited from hospital-based clinic, using self-administered questionnaire. The...
<b>Introduction:</b> ICU-acquired pneumonia (ICUAP) is the leading infection in critically ill patients. Lacking gold standard diagnostic criteria, clinical criteria are used to suggest diagnosis. A worsening oxygenation (PaO<sub>2</sub>/F<sub>I</sub>O<sub>2</sub>≤240 mmHg) proposed as criterion of ICUAP. <b>Objectives:</b> To assess adequacy PaO<sub>2</sub>/F<sub>I</sub>O<sub>2</sub>≤240 mmHg diagnose <b>Methods:</b> We prospectively assessed 426 consecutive patients with diagnosis ICUAP,...
The aim was to assess the impact of empiric antibiotic adequacy on ICU outcome patients with ventilator-associated pneumonia (VAP), reasons for inadequacy and risk factors potential multidrug-resistant organisms.
ALK gene rearrangements are important oncogenic driver alterations in non-small-cell lung cancer and a predictive factor. When present, it enables the use of tyrosine kinase inhibitors, such as Alectinib. This drug can lead to anemia erythrocyte morphological changes. We present case 72-year-old patient diagnosed with stage IV non-small cell treated Alectinib first line. The was very effective reducing tumor size but G2 acanthocytosis side effects. Anemia improved once replaced by Brigatinib.