A5030988022- Cancer Genomics and Diagnostics
- Pancreatic and Hepatic Oncology Research
- Genetic factors in colorectal cancer
- Cardiovascular Effects of Exercise
- Cardiovascular Disease and Adiposity
- Lung Cancer Treatments and Mutations
- Colorectal Cancer Surgical Treatments
- Cardiovascular Function and Risk Factors
- Colorectal Cancer Treatments and Studies
- Cancer Immunotherapy and Biomarkers
- Global Cancer Incidence and Screening
- Head and Neck Anomalies
- Soft tissue tumor case studies
- Thyroid Cancer Diagnosis and Treatment
- Advances in Oncology and Radiotherapy
- Sarcoma Diagnosis and Treatment
- Molecular Biology Techniques and Applications
- Epigenetics and DNA Methylation
- Radiomics and Machine Learning in Medical Imaging
- Colorectal and Anal Carcinomas
- Medical Imaging and Pathology Studies
- Gastrointestinal disorders and treatments
- Colorectal Cancer Screening and Detection
- Cancer Cells and Metastasis
- Thyroid and Parathyroid Surgery
Universidade do Porto
2022-2023
Hospital Universitário Lauro Wanderley
2017-2023
Universidade Federal da Paraíba
2017-2023
Universidade Federal Fluminense
2021
•The TSR is a cost-effective and robust histological parameter scored on routine hematoxylin–eosin-stained slides.•This study prospectively validates the independent prognostic effect of for patients with stage II-III colon cancer.•Stroma-high tumors (i.e. intratumoral stromal percentage >50%) significantly lead to worse DFS.•Stroma-high also exhibit chemotherapy resistance, emphasizing clinical need new therapy strategies.•Implementation in international guidelines improved guidance...
Pancreatic cancer is one of the deadliest malignancies, characterized by late-stage diagnosis and limited treatment options. Comprehensive genomic profiling plays an important role in understanding molecular mechanisms underlying disease identifying potential therapeutic targets. Cell blocks (CBs), derived from EUS-FNA, have become valuable resources for analysis. We examine profile pancreatic ductal adenocarcinoma (PDAC) using specimens obtained CB across a large gene panel, within...
The human heart contains varying amounts of fat deposits. Cardiac physiological occurs predominantly in the right ventricle (RV). discovery and characterization adipose tissue along left (LV) has been rarely reported. This study aimed to determine occurrence fatty deposits epicardial, pericoronay myocardial compartments LV, trace epidemiological profile clinical associations with this finding. Epidemiological morphological data samples were collected from corpses submitted necropsy. fixed,...
The tumor stroma plays a relevant role in the initiation and evolution of solid tumors. Tumor-stroma ratio (TSR) is histological feature that expresses proportion stromal component surrounds cancer cells. In different studies, TSR represents potential prognostic factor: rich tissue can promote invasion aggressiveness. aim this study was to evaluate reproducibility determine interobserver agreement score. estimate evaluated patients diagnosed with colorectal adenocarcinoma (CRA), who...
Abstract Several standardized systems for nongynecological cytopathology have been published following the successful implementation of The Bethesda System Reporting Cervical Cytology. Each these comprises a set reporting categories accompanied by risk malignancy. However, in most cases, malignancy estimates not based on high‐quality evidence and often may be consider proper “risks” (because they estimated cross‐sectional studies). This commentary discusses problems related to data used...
Metastatic breast cancer (MBC) remains in most cases an incurable disease with genetic complexity and heterogeneity. Improvements classification management have been introduced, addition to the development of endocrine anti-HER2 targeted therapies. Currently, efforts are being made delineate best approach for genomic landscape MBC and, as result, molecular therapeutic targets. Here, we highlight recent developments cytopathology MBC, discussing cytological diagnostic approaches...
<b><i>Introduction:</i></b> The characterization of tumor microenvironment (TME) related factors and their impact on progression have attracted much interest. We investigated cancer cells cancer-associated fibroblasts (CAFs) to evaluate biomarkers that are associated with neoplastic progression, observing them in different interface zones colorectal cancer. <b><i>Methods:</i></b> On 357 CRC tissue microarrays, using immunohistochemistry, we...
Introduction: Solitary fibrous tumors (SFTs) are a rare type of spindle cell neoplasm, composed cellular and collagenous components, predominantly arise from the pleura. SFTs liver (SFTL) uncommon with little number cases reported in English literature. The diagnosis is based on histological morphological characteristics, associated immunohistochemical markers molecular analysis. rarity this tumor makes it difficult to evaluate its prognosis natural course. Surgical resection remains...
Abstract Objectives Colorectal cancer (CRC) is the second leading cause of death in world, with survival correlated extension disease at diagnosis. In many low-/middle-income countries, incidence CRC increasing rapidly, while decreasing rates are observed high-income countries. We evaluated anatomopathological profile 390 patients diagnosed who underwent surgical resection, over a six-year period, state Paraíba, northeastern Brazil. Results Adenocarcinomas accounted for 98% cases primary...