A5037656420- Transplantation: Methods and Outcomes
- Cardiac Structural Anomalies and Repair
- Mechanical Circulatory Support Devices
- Cardiac Valve Diseases and Treatments
- Infective Endocarditis Diagnosis and Management
- Renal Transplantation Outcomes and Treatments
- Viral Infections and Immunology Research
- Polyomavirus and related diseases
- Viral-associated cancers and disorders
- Congenital Heart Disease Studies
- Cardiac Imaging and Diagnostics
- Cardiac Arrhythmias and Treatments
- Cardiac tumors and thrombi
- Cardiac pacing and defibrillation studies
- Cytomegalovirus and herpesvirus research
- Aortic Disease and Treatment Approaches
- Cardiac Arrest and Resuscitation
- Vascular anomalies and interventions
- Atrial Fibrillation Management and Outcomes
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiovascular Function and Risk Factors
- Advanced MRI Techniques and Applications
- Organ Transplantation Techniques and Outcomes
- Cardiovascular Issues in Pregnancy
- Aortic aneurysm repair treatments
Clinica Universidad de Navarra
2016-2025
Universidad de Navarra
2009-2024
Hospital Universitario 12 De Octubre
2016
Navarre Institute of Health Research
2015
Bellvitge University Hospital
2015
Complejo Hospitalario de Navarra
2012
Gobierno de Navarra
2004-2012
Azienda Ospedaliera Sant'Andrea
2008
Sociedad Española de Cardiología
2006-2007
University of Pamplona
2006
he Spanish Post-Heart-Transplant Tumour Registry comprises data on neoplasia following heart transplantation (HT) for all HT patients (1984–2003). This retrospective analysis of 3393 investigated the incidence and prognosis neoplasia, influence antiviral prophylaxis. About 50% post-HT neoplasias were cutaneous, 10% lymphomas. The cumulative skin cancers other nonlymphoma increased with age at time (from respectively 5.2 8.9 per 1000 person-years in first year to 14.8 12.6 after 10 years),...
Myocardial fibrosis is a main contributor to the development of heart failure (HF). CT-1 (cardiotrophin-1) and Gal-3 (galectin-3) are increased in HF associated with myocardial fibrosis. The aim this study analyze whether regulates Gal-3. Proteomic analysis revealed that was upregulated by human cardiac fibroblasts parallel other profibrotic proinflammatory markers. upregulation mediated ERK (extracellular signal-regulated kinase) 1/2 Stat-3 (signal transducer activator transcription 3)...
In the third report of European Registry for Patients with Mechanical Circulatory Support Association Cardio-Thoracic Surgery, outcomes patients receiving mechanical circulatory support are reviewed in relation to implant era.Procedures adult (January 2011-June 2020) were included. from centres <60% follow-ups completed excluded. Outcomes stratified into 3 eras (2011-2013, 2014-2017 and 2018-2020). Adverse event rates (AERs) calculated early phase (<3 months) late (>3 months). Risk factors...
Prolonged bleeding during cardiovascular surgery presents a risk for the patient and increases time cost of surgery. TachoSil is ready-to-use haemostatic agent that consists an equine collagen patch coated with human fibrinogen thrombin. This trial evaluated efficacy safety (< or =30 days post-surgery) surgical compared standard fleece control in patients undergoing surgery.Patients scheduled elective on heart, ascending aorta aortic arch requiring cardiopulmonary bypass were eligible this...
Cardiotrophin-1 has been shown to be profibrogenic in experimental models. The aim of this study was analyze whether cardiotrophin-1 is associated with left ventricular end-diastolic stress and myocardial fibrosis hypertensive patients heart failure. Endomyocardial biopsies from (n=31) necropsies 7 control subjects were studied. Myocardial protein mRNA the fraction volume occupied by collagen increased compared controls (P<0.001). overexpression localized cardiomyocytes. correlated type I...
Abstract OBJECTIVES This fourth report aimed to provide insights into patient characteristics, outcomes, and standardized outcome ratios of patients implanted with durable Mechanical Circulatory Support across participating centers in the European Registry for Patients (EUROMACS) registry. METHODS All registered receiving mechanical circulatory support up August 2024 were included. Expected number events predicted using penalized logistic regression. Standardized (Observed/Expected events)...
Cardiac fibrosis is mediated by the persistent activity of myofibroblasts, which differentiate from resident cardiac fibroblasts in response to tissue damage and stress signals. The signaling pathways transcription factors regulating fibrotic transformation have been thoroughly studied. In contrast, roles chromatin myofibroblast differentiation their contribution pathogenic remain poorly understood. Here, we combined bulk single-cell CRISPR screens characterize primary fibroblasts. We...
To compare left atrial performance with dual-source CT (DSCT) respect to magnetic resonance imaging (MRI) in orthotopic heart transplant recipients.Twenty-nine consecutive recipients (27 male; mean age 64.1 +/- 13 years; time from transplantation 122.8 69.7 months) referred for exclusion of cardiac allograft vasculopathy underwent DSCT and MRI. Standard biatrial technique was employed subjects whereas 16 were transplanted after the bicaval technique. Axial 5-mm slice-thickness datasets...
Objective: Our aim was to compare the efficacy of surgical versus percutaneous administration skeletal myoblasts (SkM) in a swine model chronic myocardial infarction and determine mechanism(s) involved their beneficial effect.
Cystatin C has been shown to be associated with heart failure preserved ejection fraction (HFPEF). In addition, myocardial fibrosis involved in diastolic dysfunction HFPEF. Therefore, we hypothesized that increased cystatin levels may altered collagen metabolism, contributing patients HFPEF.One hundred and forty-one elderly hypertensive HFPEF were included. Cardiac morphology function was assessed by echocardiography. Circulating of C, biomarkers type I synthesis (carboxy-terminal propeptide...
A combination of human-induced pluripotent stem cells (hiPSCs) and 3D microtissue culture techniques allows the generation models that recapitulate cardiac microenvironment for preclinical research new treatments. In particular, spheroids represent simplest approach to in generate gradients cellular access media, mimicking effects an ischemic event. However, previous required incubation under low oxygen conditions or deprived nutrient media recreate ischemia. Here, we describe large (i.e.,...
The deep inferior epigastric perforator (DIEP) flap has been shown to be a valid option for breast reconstruction, as it certain advantages over the free TRAM flap, including lower morbidity in donor area, conservation of abdominal wall function, and reduced postoperative pain. However, some cases venous congestion using DIEP have described. authors present case which return objectively (by measurment with flux meter) presented marked improvement (from 4 ml/min 13.9 ml/min) after drainage...