A5001632831- Immunodeficiency and Autoimmune Disorders
- Transplantation: Methods and Outcomes
- Cytomegalovirus and herpesvirus research
- Blood groups and transfusion
- Blood disorders and treatments
- Immune Cell Function and Interaction
- Systemic Lupus Erythematosus Research
- Reproductive System and Pregnancy
- Renal Transplantation Outcomes and Treatments
- Pneumocystis jirovecii pneumonia detection and treatment
- T-cell and B-cell Immunology
- Viral Infections and Immunology Research
- HIV Research and Treatment
- Platelet Disorders and Treatments
- Respiratory viral infections research
- Pregnancy and preeclampsia studies
- Parvovirus B19 Infection Studies
- Hepatitis C virus research
- Polyomavirus and related diseases
- COVID-19 Clinical Research Studies
- Diabetes and associated disorders
- Prenatal Screening and Diagnostics
- Pneumonia and Respiratory Infections
- Cystic Fibrosis Research Advances
- HIV/AIDS Research and Interventions
Hospital General Universitario Gregorio Marañón
2015-2024
Centro de Investigación en Red en Enfermedades Cardiovasculares
2024
International Society for Heart and Lung Transplantation
2023-2024
IFC Research (United Kingdom)
2024
Advanced Circulatory System (United States)
2023
Hospital Universitario Puerta de Hierro Majadahonda
2023
Universidad Complutense de Madrid
2011-2022
Grifols (United States)
2016
Biotest (Germany)
2016
Hospital Universitario La Paz
2016
Problem Natural killer ( NK , CD 3 − 56 + / 16 ) and NKT ‐like cells activity is considered among the key factors for reproductive success. In absence of immunological screening, beneficial effects intravenous immunoglobulin IVIG in preventing recurrent failure RRF have not been reported. Here, we analyse influence on pregnancy success women with circulating or/and expansion. Method study One hundred fifty‐seven previous miscarriage and/or implantation after vitro fertilization were...
Summary Recurrent respiratory tract infections (RRTIs) are common clinical conditions in individuals with alterations of the immune function. A prospective open pilot study a cohort patients RRTIs has been performed to assess whether sublingual immunization polyvalent bacterial vaccine could exert an immunomodulatory effect on antigen-specific immunological responses and have impact outcome. Seventeen were recruited. An oral preparation (Bactek®) was administered all daily for 6 months....
Summary Splenectomy has been used in patients with common variable immunodeficiency disorders (CVID), mainly the context of refractory autoimmune cytopenia and suspected lymphoma, but there are understandable concerns about potential compounding an existing immunodeficiency. With increasing use rituximab as alternative treatment for cytopenia, role splenectomy CVID needs to be re-examined. This retrospective study provides largest cohesive data set date describing outcome 45 past 40 years....
Problem Recurrent reproductive failure ( RRF ) has been associated with expansion of circulating NK cells, key cells for maternal tolerance, decidual vasculogenesis and embryo growth. This study reports our experience in intravenous immunoglobulin IVI g) therapy a large cohort women expanded and/or NKT ‐like (blood are heterogeneous subset T that share properties both cells). Method Observational or (>12% 10% cutoff levels total lymphocytes, respectively), treated g the next gestation....
Proteolytic shedding of ligands for the NK group 2D (NKG2D) receptor is a strategy used by tumors to modulate immune recognition cells and cytotoxic T cells. A number metalloproteases, especially those disintegrin metalloprotease (ADAM) family, can mediate NKG2D ligand cleavage this process be modulated expression thiol isomerase ERp5. In article, we describe that an increased MICA observed postinfection with several strains human CMV due enhanced activity ADAM17 (TNF-α converting enzyme)...
Objective To identify subsets of CD4 T lymphocytes that can predict the development AIDS and to assess whether increased levels these cellular markers could provide additional independent prognostic information cell count plasma HIV-1-RNA levels. Design methods In a prospective study, cohort 85 HIV-positive intravenous drug users [clinical categories CDC classification A (n = 48) B 37)] were followed for period 37 ± 13 months. Memory activated CD8 cells quantitated by three-colour flow...
ABSTRACT Objective To evaluate the efficiency of first‐trimester fetal growth restriction (FGR), low pregnancy‐associated plasma protein A (PAPP‐A), and their combination for predicting small gestational age (SGA) at delivery. Methods Retrospective cohort study women undergoing aneuploidy screening. Fetal crown–rump lengths (CRLs) were 10 to 14 weeks’ gestation converted adjusted Z ‐scores. Low PAPP‐A was defined as levels < 5th percentile GA. Receiver‐operating characteristic curves used...
Evaluation of specific antibody (Ab) response to polysaccharide antigens is essential for diagnosis primary immunodeficiencies. We assessed the Ab responses pneumococcal-polysaccharide (PPV) and Salmonella typhi-polysaccharide (TyphimVi) vaccines in a prospective study (EMPATHY) patients with common variable immunodeficiency (CVID-Group, n = 22), hypogammaglobulinemia (HYPOG-Group; 27) healthy controls (HC-Group; 16). Specific concentrations PPV TyphimVi were measured by ELISA (The Binding...
We report one case of pregnancy-onset severe diffuse proliferative nephritis in a patient with systemic lupus erythematosus (SLE), who was successfully treated combination anti-tumour necrosis factor (TNF)-alpha, plasmapheresis and high-dose intravenous gammaglobulin. No flares were observed either clinical symptoms or laboratory examinations during pregnancy after delivery. Her autoantibodies except fluorescent anti-nuclear antibodies negative. suggest that anti-TNF-alpha, gammaglobulin may...
Abstract Background We previously reported how specific humoral and cellular immunological markers that are readily available in clinical practice can be used to identify heart transplant recipients ( HTR ) at risk of developing severe infections. In this study, we perform an extended analysis profiles could prove superior individual assessing the infection early after transplantation. Methods a prospective follow‐up evaluated 100 1 week Laboratory tests included determination immunoglobulin...
Abstract: Infectious complication represents a significant source of morbidity and mortality in heart transplant recipients. To assess humoral immunity markers that can predict the development infection, 38 consecutive recipients transplants performed at single center were prospectively studied. Induction therapy included daclizumab. Immunoglobulin (IgG, IgA, IgM) complement factors (C3, C4, factor B) by nephelometry peripheral blood samples obtained before transplantation, 7 days 1 month...
Objetive. Few studies have assessed immunophenotypic abnormalities on lymphocyte subsets in patients with antiphospholipid syndrome (APS). We performed an extended immunological study to define alterations of distinct T, B, and natural killer (NK) cell obstetric APS their relationship APS–associated complications. Methods. Patients controls: 36 women [Sydney criteria, Group A1 without thrombosis (n = 26), A2 10)]; age matched recurrent abortion antibodies (disease controls; B), healthy...
Abstract IgG hypogammaglobulinemia is a risk factor for infection in heart recipients. We assessed reconstitution of humoral immunity after non‐specific intravenous immunoglobulin ( IVI g) replacement therapy administered to treat secondary recipients with severe infections. The study population comprised 55 who were g group) and no infectious complications (control group). An event was defined as requiring drug during the first year transplantation. protocol 5% pasteurized at dose 300–400...
Abstract Background Immunoglobulin G (IgG) hypogammaglobulinemia ( HGG ) is a risk factor for development of severe infections after heart transplantation. We performed clinical trial to preliminarily evaluate the efficacy and safety early administration intravenous immunoglobulin IVIG prevention infection in recipients with post‐transplant IgG . Methods Twelve detected screening phase (IgG <500 mg/dL) were recruited. Patients received (Flebogamma 5%), as follows: 2 doses 200 mg/kg...