A5107964181- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- HIV/AIDS Research and Interventions
- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- HIV-related health complications and treatments
- Cytomegalovirus and herpesvirus research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Hepatitis B Virus Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Respiratory Support and Mechanisms
- Immune Cell Function and Interaction
- Liver Disease and Transplantation
- Cardiac Arrest and Resuscitation
- Hemodynamic Monitoring and Therapy
- Acute Kidney Injury Research
- Mechanical Circulatory Support Devices
- Cardiac, Anesthesia and Surgical Outcomes
- Hemoglobinopathies and Related Disorders
- Sepsis Diagnosis and Treatment
- Iron Metabolism and Disorders
- Dialysis and Renal Disease Management
- Acute Myeloid Leukemia Research
- Renal function and acid-base balance
- Blood groups and transfusion
Hospital General Universitario Gregorio Marañón
2016-2025
Instituto de Salud Carlos III
2020-2024
Centro de Investigación Biomédica en Red
2021-2024
Brookhaven National Laboratory
2024
Universidad Complutense de Madrid
2006-2023
Centro de Investigación en Red en Enfermedades Cardiovasculares
2021
Instituto de Investigación Sanitaria La Fe
2020
Hospital Universitari i Politècnic La Fe
2020
Hospital Universitario La Paz
2004-2016
Hospital de Clínicas
2016
Human immunodeficiency virus (HIV) infection modifies the natural history of chronic hepatitis C, thus promoting more rapid progression to cirrhosis and end-stage liver disease. The objective our study was determine whether C (HCV) clearance is associated with improved clinical outcomes in patients positive for HIV HCV. It an ambispective cohort carried out 11 units Spain involved 711 consecutive HIV/HCV who started interferon plus ribavirin therapy between 2000 2005. We measured sustained...
Background. Sustained virological response (SVR) after therapy with interferon plus ribavirin reduces liver-related complications and mortality in patients coinfected human immunodeficiency virus (HIV) hepatitis C (HCV). We assessed the effect of SVR on HIV progression not related to liver disease.
Abstract Purpose. To assess the usefulness of sonographic measurement median nerve cross‐sectional area (CSA) in diagnosis carpal tunnel syndrome (CTS) and grading its severity using conduction (NC) studies as standard. Method. The CSA was measured at inlet outlet ellipse formula automatic tracing 72 hands with suspicion CTS. Result. lack inter‐reader reliability led to excluding measurements obtained outlet. Based on receiver operating characteristic curves, following cut‐off points for...
Objective To develop and validate a prediction model of mortality in patients with COVID-19 attending hospital emergency rooms. Design Multivariable prognostic model. Setting 127 Spanish hospitals. Participants Derivation (DC) external validation (VC) cohorts were obtained from multicentre single-centre databases, including 4035 2126 confirmed COVID-19, respectively. Interventions Prognostic variables identified using multivariable logistic regression. Main outcome measures 30-day mortality....
Transient elastography (FibroScan) is a novel, rapid and noninvasive technique to assess liver fibrosis. Our objective was compare transient (TE) other serum indexes as alternatives biopsy in HIV/hepatitis C virus (HCV)-coinfected patients. The fibrosis stage (METAVIR Score), TE, the aspartate aminotransferase-to-platelet ratio index, Forns FIB-4 HGM-2 were assessed 100 patients between January 2007 2008. diagnostic values compared by calculating area under receiver operating characteristic...
Abstract Despite being a cardinal experimental model, the induction of cirrhosis in rats by repeated exposure to carbon tetrachloride (CCl4) has low reproducibility. Here, we compared two models induced orogastric administration CCl4 once (CCl4-1xWk) or twice week (CCl4-2xWk) for 12 weeks male Sprague-Dawley rats. Control received water instead CCl4. Both protocols similarly attenuated body weight gain (p < 0.01 vs. Control). Although both increased hepatic fibrosis, portal hypertension...
Abstract Background Drug–drug interactions (DDIs) that involve antiretrovirals (ARVs) tend to cause harm if unrecognized, especially in the context of comorbidity and polypharmacy. Methods A linkage was established between drug dispensing registry Madrid Liverpool human immunodeficiency virus (HIV) DDI database (January 2017–June 2017). Polypharmacy defined as use ≥5 non-HIV medications, DDIs were classified by a traffic-light ranking for severity. Results total 22 945 people living with HIV...
Background and Aims: We assessed long-term clinical outcomes prognostic factors for liver disease progression after sustained viral response with direct-acting antivirals in patients coinfected HIV/HCV advanced fibrosis or cirrhosis. Approach Results: A total of 1300 who achieved from 2014 to 2017 Spain were included: 1145 compensated chronic (384 761 cirrhosis) 155 decompensated The median follow-up was 40.9 months. Overall, 85 deaths occurred, 61 due non-liver non-AIDS–related causes that...
Background: There are few data on long-term effects of highly active antiretroviral therapy (HAART) weight and height in HIV-infected children. Objectives: Our objective was to assess the effect HAART children over time Madrid cohort, analyze possible factors associated with effect. Patients methods: This a retrospective study starting 1997 or later. Serial measurements weight, body mass index (BMI) were performed converted z-scores using Spanish revised reference data. Changes from baseline...
Line-of-sight free-space optical links can provide extremely high bandwidth communications, but this usually requires that transmitter and receiver are precisely aligned. In order to allow terminals be mobile, must able track users within their field of view so the link is maintained. There various means do this, all require complex subsystems with a number different optical, optoelectronic, electrical components. A solid-state tracking architecture introduced seven-channel system...
Continuous renal replacement therapy (CRRT) frequently gives rise to complications in critically ill children. However, no studies have analyzed these prospectively. The purpose of this study was analyze the CRRT children and associated risk factors.A prospective, single-centre, observational performed all treated using order determine incidence related technique (problems catheterization, hypotension at time connection CRRT, hemorrhage, electrolyte disturbances) their relationship with...
Children are at higher risk of tuberculosis (TB) dissemination and extrapulmonary disease, contributing greatly to TB-associated morbidity long-term sequelae. However, there very few studies that assess the impact clinical spectrum pediatric TB (EPTB) in low-prevalence regions.Children <18 years age diagnosed with Madrid region (2005-2013) were reviewed. We compared epidemiology, characteristics performance diagnostic tests childhood pulmonary disease. performed a multivariate logistic...
We assessed non-liver-related non-acquired immunodeficiency syndrome (AIDS)-related (NLR-NAR) events and mortality in a cohort of human virus (HIV)/hepatitis C (HCV)-coinfected patients treated with interferon (IFN) ribavirin (RBV), between 2000 2008. The censoring date was May 31, 2014. Cox regression analysis performed to assess the adjusted hazard rate (HR) overall death responders nonresponders. Fine Gray conducted determine subhazard (sHR) NLR deaths NLR-NAR considering as competing...
Although highly prevalent throughout the world, accurate prevalence of hemoglobinopathies in Spain is unknown.This study presents data on national registry patients with thalassemia major (TM), intermedia (TI), and sickle cell disease (SCD) created 2014. Fifty centers reported cases retrospectively. Data were registered from neonatal screening or first contact at diagnosis until last follow-up death.Data 715 eligible collected: 615 SCD (497 SS, 64 SC, 54 SBeta phenotypes), 73 thalassemia, 9...
With the aim of improving access and engagement to healthcare in people living with HIV (PLHIV), 2022 Gregorio Marañón Hospital NGO COGAM developed a circuit for recruitment referral hospital. Program targeted PLHIV who were neither receiving antiretroviral treatment (ART) nor on medical follow-up (FU); but also, individuals at risk underwent screening tests and, if positive, referred confirmation. The result was an increase annual new seen hospital by reaching population were, essentially,...
Background. Use of antiretroviral therapy has resulted in a decrease morbidity and mortality rates human immunodeficiency virus type 1 (HIV-1)-infected children.Methods. We performed retrospective study involving 427 children to determine the effectiveness different protocols on clinical outcome. The follow-up period was divided into 5 calendar periods (CPs): CP1 (1980-1989), before administered; CP2 (1990-1993), when monotherapy CP3 (1994-1996), combined CP4 (1997-1998), </=50% were...
Shockable rhythms are rare in pediatric cardiac arrest and the results of defibrillation uncertain. The objective this study was to analyze cardiopulmonary resuscitation that included children.Forty-four out 241 children (18.2%) who were resuscitated from inhospital or out-of-hospital had been treated with manual defibrillation. Data recorded according Utstein style. Outcome variables a sustained return spontaneous circulation (ROSC) 1-year survival. Characteristics patients...
Abstract Introduction One of the greatest problems with continuous renal replacement therapy (CRRT) is early coagulation filters. Few studies have monitored circuit function prospectively. The purpose this study was to determine variables associated life in critically ill children CRRT. Methods A prospective observational performed 122 treated CRRT a pediatric intensive care unit from 1996 2006. Patient and filter characteristics were analyzed their influence on life. Data collected 540...