A5012003923- Hepatitis C virus research
- HIV/AIDS drug development and treatment
- HIV/AIDS Research and Interventions
- HIV Research and Treatment
- Liver Disease Diagnosis and Treatment
- HIV-related health complications and treatments
- Hepatitis B Virus Studies
- Infective Endocarditis Diagnosis and Management
- Cytomegalovirus and herpesvirus research
- Liver Disease and Transplantation
- Cardiac Valve Diseases and Treatments
- MicroRNA in disease regulation
- Cardiac Structural Anomalies and Repair
- Pneumocystis jirovecii pneumonia detection and treatment
- Telomeres, Telomerase, and Senescence
- Extracellular vesicles in disease
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cardiac Arrhythmias and Treatments
- Pericarditis and Cardiac Tamponade
- Cardiac pacing and defibrillation studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Myasthenia Gravis and Thymoma
- HIV, Drug Use, Sexual Risk
- Mechanical Circulatory Support Devices
- Bacterial biofilms and quorum sensing
King's College Hospital NHS Foundation Trust
2024
Berkshire Healthcare NHS Foundation Trust
2024
Research Institute Hospital 12 de Octubre
2018-2024
Centro de Investigación Biomédica en Red
2024
Hospital Universitario 12 De Octubre
2015-2024
University College London
2023
University of London
2023
King's College London
2023
King's College Hospital
2023
Universidad Complutense de Madrid
2006-2022
Cross-linking of Fas (CD95) induces apoptosis, a response that has been reported to depend upon the Ras activation pathway. Since many examples apoptosis have involve AP-1 and/or AP-1-activation AP-1-activating enzyme Jun kinase (JNK), downstream effectors or Ras-like small GTP-binding proteins, we evaluated role these molecules in Fas-mediated apoptosis. Although cross-linking on Jurkat T cells did result JNK activation, increased activity was observed relatively late, being detectable only...
Our objective was to assess the therapeutic noninferiority of dual therapy with darunavir/ritonavir and lamivudine compared triple plus 2 nucleos(t)ides for maintenance human immunodeficiency virus type 1 (HIV-1) suppression.This a multicenter, open-label, trial (margin 12%). Patients HIV-1 RNA <50 copies/mL 6 months or longer on (tenofovir disoproxil fumarate emtricitabine abacavir lamivudine) no resistance were randomized continue (n = 128) switch 129). The primary endpoint proportion...
We evaluated treatment outcomes in a prospective registry of human immunodeficiency virus/hepatitis C virus (HCV)–coinfected patients treated with interferon‐free direct‐acting antiviral agent–based therapy hospitals from the region Madrid between November 2014 and August 2016. assessed sustained viral response at 12 weeks after completion used multivariable logistic regression to identify predictors failure. 2,369 patients, whom 59.5% did not have cirrhosis, 33.9% had compensated 6.6%...
Background and Aims: We assessed long-term clinical outcomes prognostic factors for liver disease progression after sustained viral response with direct-acting antivirals in patients coinfected HIV/HCV advanced fibrosis or cirrhosis. Approach Results: A total of 1300 who achieved from 2014 to 2017 Spain were included: 1145 compensated chronic (384 761 cirrhosis) 155 decompensated The median follow-up was 40.9 months. Overall, 85 deaths occurred, 61 due non-liver non-AIDS–related causes that...
Objective: Social determinants of health (SDH) are important long-term conditions and multimorbidity in the general population. The intersecting relationship between SDH people with HIV remains poorly studied. Design: A cross-sectional study investigating relationships eight socio-economic parameters prevalent comorbidities clinical significance adults African ancestry aged 18–65 years South London, UK. Methods: Multivariable logistic regression analysis was used to evaluate associations...
We analysed hepatitis C virus (HCV) reinfection among participants in a prospective registry of HIV/HCV-coinfected patients treated with all-oral direct-acting antiretroviral (DAA)-based therapy the region Madrid.An observational cohort study.The study period started on date sustained viral response (SVR) was confirmed. The censoring 31 December 2017. SVR defined as negative HCV-RNA 12 weeks after completion treatment. Reinfection positive test result achievement SVR.Reinfections were...
With the purpose of reducing well-known negative impact late presentation (LP) on people living with HIV (PLWH), guidelines early diagnosis were published in 2014 Spain, but since then no data LP prevalence have been published. To estimate and risk factors to evaluate their development clinical outcomes Cohort Spanish HIV/AIDS Research Network (CoRIS) during 2004-2018.CoRIS is an open prospective multicenter cohort PLWH, adults, naive ART at entry. was defined as CD4 count ≤350 cells/μL or...
Abstract Objectives We assessed the prevalence of anti‐hepatitis C virus (HCV) antibodies and active HCV infection (HCV‐RNA‐positive) in people living with HIV (PLWH) Spain 2019 compared results those four similar studies performed during 2015–2018. Methods The study was 41 centres. Sample size estimated for an accuracy 1%. Patients were selected by random sampling proportional allocation. Results reference population comprised 973 PLWH, sample 1325. serostatus known 1316 PLWH (99.3%), whom...
Extracellular vesicles (EVs) are an increasingly promising tool for liquid biopsy in liver diseases. Hepatitis C Virus (HCV) infection, alone or together with Human Immunodeficiency (HIV) infection significantly impacts on the microRNA (miRNA) EVs content resembling chronic hepatitis (CHC) progression. The objective of study was to delve into intricate EVs-miRNA profiles CHC patients different fibrosis stages, aiming pinpoint non-invasive markers capable distinguishing significant fibrosis....
Background. The purpose of this study was to assess the prevalence anti-hepatitis C virus (HCV) antibodies (Abs) and active HCV infection in human immunodeficiency (HIV)-infected (HIV+) patients Spain 2015. This a cross-sectional study. Methods. performed 41 centers Sample size estimated for an accuracy 2%, number from each hospital determined by proportional allocation, were selected using simple random sampling. Results. reference population 35 791 patients, sample 1867 patients. Hepatitis...
BackgroundWe investigated the efficacy of a switch to dolutegravir plus lamivudine in aviremic individuals without evidence persistent resistance-associated mutations baseline proviral DNA population sequencing.MethodsOpen-label, single-arm, 48-week pilot trial. HIV-1 infected adults, naïve integrase inhibitors, with CD4+ above 350 cell/μL and fewer than 50 RNA copies per mL year prior study entry switched lamivudine. Participants were excluded if genotyping detected mutations. To detect...
Phosphoinositide (PI) 3-kinase has been implicated in T cell receptor (TCR) signaling, either as a positive or negative regulatory molecule. Here, we show that for normal mouse lymph node cells, PI activity is required interleukin-2 (IL-2) production following TCR-mediated activation. Furthermore, inhibition of prevented activation enzymes the extracellular signal-regulated protein kinase (ERK) signaling pathway (MEK-1 and ERK-2). Overexpression dominant-negative mutant pharmacological...
In HIV-1/HCV-coinfected patients, chronic HCV infection leads to an increased T-lymphocyte immune activation compared HIV-monoinfected thereby likely contributing increase HIV-1 reservoir that is the major barrier for its eradication. Our objective was evaluate influence of coinfection in viral size resting (r) CD4+ T-cells (CD25-CD69-HLADR-). Multicenter cross-sectional study 97 cART-treated including 36 patients with HIV and HCV-chronic co-infection without anti-HCV treatment, 32...
In the ART-PRO pilot trial there were no virological failures through 48 weeks of treatment with dolutegravir plus lamivudine in suppressed individuals and without archived resistance-associated mutations (RAMs) detected next-generation sequencing (NGS) but evidence RAMs baseline proviral DNA population sequencing.To present 96 week results from ART-PRO.Open-label, single-arm trial. At baseline, all participants switched to lamivudine. Participants excluded if genotyping RAMs. To detect...
Objectives: The aim of this study was to examine the impact late presentation (CD4 + cell count <350 cells/μl or an AIDS-defining event) on effectiveness and safety initial antiretroviral therapy (ART) evaluate whether treatment response depends first-line ART regimen in presenters. Design: ART-naive adults from Cohort Spanish HIV/AIDS Research Network (CoRIS) starting triple between 2010 2018. Methods: We used multivariable models assess differences viral suppression (viral load <50...
Patients with chronic hepatitis C and stage 3 fibrosis are thought to remain at risk of hepatocellular carcinoma after sustained virological response. We investigated this in a large cohort patients well-defined fibrosis.We performed multicentre, ambispective, observational study response treatment direct-acting antivirals started between January December 2015. Baseline was defined two-step procedure: we selected transient elastography values 9.5-14.5 kPa subsequently excluded those nodular...
Summary Guidelines recommend evaluating persistent alteration of liver tests in HCV‐infected patients after sustained virological response (SVR) and its influence on disease progression. We studied the prevalence, etiology, associated factors evolutionary implications HCV direct‐acting antivirals (DAA)‐induced SVR. This was a prospective study SVR DAA. Those with another previously diagnosed were excluded. Persistent defined as any increase ALT, AST or GGT at SVR12 SVR24. Causes determined...
ABSTRACT A presumptive chromosomal cephalosporinase (pI, 9.0) from a clinical strain of Acinetobacter genomic species 3 (AG3) is reported. The nucleotide sequence this β-lactamase shows for the first time gene encoding an AmpC enzyme in AG3. In addition, biochemical properties novel AG3 are reported
Background There are no validated waist circumference (WC) cut-offs to define metabolic syndrome in Black people with HIV. Methods Cross-sectional analyses within the CKD-AFRICA study. We used Pearson correlation coefficients and receiver operating characteristic (ROC) curves describe relationship between WC cardiometabolic parameters including triglycerides, cholesterol, glucose, glycated haemoglobin (HbA1c), homeostatic model assessment for insulin resistance (HOMA-IR), identify optimal...
Abstract Objectives Our objective was to describe the prevalence of cardiovascular disease (CVD) risk factors in people African ancestry with HIV UK. Methods We conducted a cross‐sectional analysis CVD Black aged ≥40 years and estimated 10‐year using QRISK®3‐2018. Correlations between body mass index (BMI) were described Pearson correlation coefficients, associated ≥5% logistic regression. Results included 833 median age 54 years; 54% female, 50% living obesity (BMI ≥30 kg/m 2 ), 61% had...
Hepatitis C virus (HCV) coinfection with human immunodeficiency (HIV) has a detrimental impact on disease progression. Increasing evidence points to extracellular vesicles (EVs) as important players of the host-viral cross-talk. The microRNAs (miRNAs), essential components EVs cargo, are key regulators normal cellular processes and also promote viral replication, pathogenesis, We aimed characterize plasma-derived miRNA signature chronic HCV infected HIV coinfected patients unravel molecular...