A5031604063- MicroRNA in disease regulation
- Hepatitis C virus research
- Cytomegalovirus and herpesvirus research
- Extracellular vesicles in disease
- Telomeres, Telomerase, and Senescence
- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- Circular RNAs in diseases
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- RNA modifications and cancer
- RNA Research and Splicing
- Advanced Electrical Measurement Techniques
- Cancer-related molecular mechanisms research
- Escherichia coli research studies
- Pharmaceutical and Antibiotic Environmental Impacts
- HIV/AIDS Research and Interventions
- Immune cells in cancer
- HIV-related health complications and treatments
- Liver Disease Diagnosis and Treatment
- Antibiotic Resistance in Bacteria
Instituto de Salud Carlos III
2020-2025
Centro de Investigación Biomédica en Red
2024-2025
Centro Nacional de Microbiologia
2022
MicroRNAs (miRNAs) have a crucial role in regulating immune response against infectious diseases, showing changes early disease onset and before the detection of pathogen. Thus, we aimed to analyze plasma miRNA profile at COVID-19 identify miRNAs as prognostic biomarkers severity survival.Plasma miRNome 96 patients that developed asymptomatic/mild, moderate severe was sequenced together with group healthy controls. Plasma immune-related were also assessed. showed 200 significant...
Extracellular vesicles (EVs) are an increasingly promising tool for liquid biopsy in liver diseases. Hepatitis C Virus (HCV) infection, alone or together with Human Immunodeficiency (HIV) infection significantly impacts on the microRNA (miRNA) EVs content resembling chronic hepatitis (CHC) progression. The objective of study was to delve into intricate EVs-miRNA profiles CHC patients different fibrosis stages, aiming pinpoint non-invasive markers capable distinguishing significant fibrosis....
Introduction Carbapenemase-Producing Escherichia coli (CP-Eco) isolates, though less prevalent than other CP-Enterobacterales, have the capacity to rapidly disseminate antibiotic resistance genes (ARGs) and cause serious difficult-to-treat infections. The aim of this study is phenotypically genotypically characterizing CP-Eco isolates collected from Spain better understand their mechanisms population structure. Methods Ninety representative received 2015 2020 25 provinces 59 hospitals...
Hepatitis C virus (HCV) coinfection with human immunodeficiency (HIV) has a detrimental impact on disease progression. Increasing evidence points to extracellular vesicles (EVs) as important players of the host-viral cross-talk. The microRNAs (miRNAs), essential components EVs cargo, are key regulators normal cellular processes and also promote viral replication, pathogenesis, We aimed characterize plasma-derived miRNA signature chronic HCV infected HIV coinfected patients unravel molecular...
Coinfection with hepatitis C virus (HCV) influences HIV reservoir size. However, it is unknown whether this coinfection also induces a higher provirus transcription. Viral transcription promoted by synergy between cellular factors such as NF-κB and the viral regulator Tat. The impact of HCV on was analyzed in resting (r)CD4 T+ cells (CD3+CD4+CD25-CD69-HLADR-) rCD4 T cells-depleted PBMCs (rCD4 T- PBMCs) from multicenter cross-sectional study 115 cART-treated patients: 42 HIV+/HCV+ coinfected...
Background: Although human immunodeficiency virus type 1 (HIV-1) reservoir size is very stable under antiretroviral therapy (ART), individuals exposed to the Hepatitis C (HCV) (chronically coinfected and spontaneous clarifiers) show an increase in HIV spliced viral RNA, which could indicate that protein regulator Tat being more actively synthesized and, thus, lead a higher yield of new HIV. However, it still unknown whether effect HCV elimination with direct-acting antivirals (DAAs) modify...
Gender-specific consequences after HCV eradication are unexplored. MicroRNAs (miRNAs) play a crucial role in the immune response against viral infections. However, few have highlighted miRNA sex-biased disease or therapy response. We aim to assess gender differences reflected expression of HIV/HCV-coinfected patients who achieve sustained virological (SVR) with direct acting antivirals (DAAs). conducted prospective study PBMCs from 28 chronic (HIV/HCV) at baseline and achieving SVR DAAs....
We identified that acute or chronic Hepatitis C (HCV) infection in people living with HIV (PLWHIV) results different senescence profiles. However, variations these profiles after HCV elimination, spontaneously direct-acting antivirals (DAAs), remain unclear.Longitudinal observational study (48 weeks) 70 PLWHIV: 23 PLWHIV active HCV-chronic (CHC) before and eradication DAAs, 12 who clarify the (SC), 35 controls (HIV). Oxidative stress was quantified at DNA, lipid, protein, nitrate levels, as...
Abstract Coinfection with hepatitis C virus (HCV) and human immunodeficiency (HIV) increases immune activation, inflammation, oxidative stress that could lead to premature senescence. Different HCV infections, either acute or chronic infection, distinct cellular senescence in people living HIV (PLWHIV). Observational study 116 PLWHIV under antiretroviral treatment different status: (i) n = 45 chronically infected (CHC); (ii) 36 individuals who spontaneously clarify (SC); (iii) 35 controls....
Micro RNAs (miRNAs) are essential players in HIV and HCV infections, as both viruses modulate cellular miRNAs interact with the miRNA-mediated host response. We aim to analyze miRNA profile of patients different exposure explore specific signatures PBMCs for each type infection. massively sequenced small from 117 HIV+ infected patients: 45 chronically (HIV/HCV+), 36 that spontaneously clarified after acute infection (HIV/HCV-) without previous (HIV). Thirty-two healthy were used controls...
Abstract Non-coding RNAs are key regulatory molecules that govern a myriad of biological process by interacting and modulating the expression their target protein-coding genes. The combination RNA large-scale sequencing computational analyses has revealed existence vast diversity species with essential roles in functions. However, dealing huge network interactions become challenge urgent need for new tools arisen. We present CORALIS, an R package statistical analysis visualization...
Abstract Background : Co-infection with Hepatitis C virus (HCV) and Human Immunodeficiency Virus (HIV) increase immune activation, inflammation oxidative stress that could lead to premature senescence. Different HCV infection, either acute or chronic distinct cellular senescence in people living HIV (PLWHIV). Methods Observational study 116 PLWHIV different status: i) n=45 chronically infected (CHC); ii) n=36 individuals who spontaneously clarify (SC); iii) n= 35 controls. Oxidative...
Abstract Background : Previously, we identified that different HCV infection, either acute or chronic infection in people living with HIV (PLWHIV) drives dissimilar cellular senescence profile. However, variations these profiles after clearance, spontaneously direct-acting antivirals (DAAs), remains unclear. Methods Longitudinal observational study (48 weeks of follow-up) 70 PLWHIV status: 23 active HCV-chronic (CHC) before and eradication DAAs, 12 who clarify the (SC), 35 controls (HIV),...
Abstract Non-coding RNAs are key regulatory molecules that govern a myriad of biological process by interacting and modulating the expression their target protein-coding genes. The combination RNA large-scale sequencing computational analyses has revealed existence vast diversity species with essential roles in functions. However, dealing huge network interactions become challenge urgent need for new tools arisen. We present CORALIS, an R package statistical analysis visualization...