A5032390176- Health and Lifestyle Studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Diabetes Management and Research
- Nutrition, Genetics, and Disease
- Pregnancy and preeclampsia studies
- Hormonal and reproductive studies
- Travel-related health issues
- Metabolism, Diabetes, and Cancer
- Vibrio bacteria research studies
- Obesity, Physical Activity, Diet
- Neonatal Respiratory Health Research
- Public Health and Social Inequalities
- Reproductive Biology and Fertility
- Ovarian function and disorders
- Infant Development and Preterm Care
- Labor Law and Work Dynamics
- Developmental and Educational Neuropsychology
- Surgical Simulation and Training
- Adrenal Hormones and Disorders
- Educational Research and Science Teaching
- Congenital Diaphragmatic Hernia Studies
- Anatomy and Medical Technology
University of Zulia
2014-2024
Hospital General San Jorge
2017-2021
Agencia Española de Medicamentos y Productos Sanitarios
2018-2019
Madrid Health Service
1998-2019
Sociedad Española de Nefrología
2017-2018
Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable
2017
Hospital Clínico Universitario Lozano Blesa
2011
Ministry of Health
2009
Photoaging (PA) is considered a silent disease affecting millions of people globally and defined as skin damage due to prolonged exposure ultraviolet radiation (UVR) from the sun. Physiologically, in state renewal synthesis components extracellular matrix (ECM). However, UVR affects production ECM, functioning response cells begins change, thus expressing clinical phenotypic characteristics PA. The primary mechanisms involved PA are direct DNA cells, increases oxidative stress, activation...
During pregnancy, women undergo several metabolic changes to guarantee an adequate supply of glucose the foetus. These modifications develop what is known as physiological insulin resistance. When this process altered, however, gestational diabetes mellitus (GDM) occurs. GDM a multifactorial disease, and genetic environmental factors play crucial role in its aetiopathogenesis. has been linked both macroscopic molecular alterations placental tissues that affect physiology. This review...
We evaluated treatment outcomes in a prospective registry of human immunodeficiency virus/hepatitis C virus (HCV)–coinfected patients treated with interferon‐free direct‐acting antiviral agent–based therapy hospitals from the region Madrid between November 2014 and August 2016. assessed sustained viral response at 12 weeks after completion used multivariable logistic regression to identify predictors failure. 2,369 patients, whom 59.5% did not have cirrhosis, 33.9% had compensated 6.6%...
Background and Aim . Insulin resistance (IR) is a prominent pathophysiologic component in myriad of metabolic disorders, including obesity, prediabetes, type 2 diabetes mellitus, which are common our locality. The objective this study was to determine the prevalence IR factors associated with condition an adult population from Maracaibo city, Venezuela. Methodology A cross-sectional, descriptive multistaged randomized sampling carried out 2026 adults. defined as HOMA2-IR ≥ 2. multiple...
We analysed hepatitis C virus (HCV) reinfection among participants in a prospective registry of HIV/HCV-coinfected patients treated with all-oral direct-acting antiretroviral (DAA)-based therapy the region Madrid.An observational cohort study.The study period started on date sustained viral response (SVR) was confirmed. The censoring 31 December 2017. SVR defined as negative HCV-RNA 12 weeks after completion treatment. Reinfection positive test result achievement SVR.Reinfections were...
Background: Insulin resistance (IR) evaluation is a fundamental goal in clinical and epidemiological research. However, the most widely used methods are difficult to apply populations with low incomes. The triglyceride-glucose index (TGI) emerges as an alternative use daily practice. Therefore objective of this study was determine optimal cutoff point for TGI adult population from Maracaibo, Venezuela. Methods: This sub-study Maracaibo City Metabolic Syndrome Prevalence Study, descriptive,...
Vessel Plus is an open acccess journal, which publishes articles related to vascular diseases, including acute respiratory distress syndrome, aneurysm, atherosclerosis, hypertension, stroke, peripheral or pulmonary etc.
<ns4:p><ns4:bold>Background:</ns4:bold> Insulin resistance (IR) evaluation is a fundamental goal in clinical and epidemiological research. However, the most widely used methods are difficult to apply populations with low incomes. The triglyceride-glucose index (TGI) emerges as an alternative use daily practice. Therefore objective of this study was determine optimal cutoff point for TGI adult population from Maracaibo, Venezuela.</ns4:p><ns4:p> <ns4:bold>Methods:</ns4:bold> This sub-study...
Traveler's diarrhea (TD) is the most frequent disease among people from industrialized countries who travel to less developed ones, especially sub-Saharan Africa, Southern Asia and South America. The common bacteria causing TD enterotoxigenic Escherichia coli (ETEC). WC/rBS cholera vaccine (Dukoral) has been shown induce cross-protection against ETEC by means of B subunit toxin. aim study was evaluate effectiveness in preventing TD.
Late preterm (LP) infants (34 -36 weeks of gestation) are the largest group and also least studied so far. In order to improve their care reduce impact increased morbidity mortality, it is essential know current situation in Spain.Clinical-epidemiological variables LP population 34 participating hospitals were prospectively collected from 1 April 2011 31 March 2016, then compared with Minimum Perinatal Data Set for term births database.Of 9,121 studied, 21.7% 34, 30.8% 35, 47.5% 36...
Abstract Autism spectrum disorder (ASD) is a neurodevelopmental disability with high heritability yet the genetic etiology remains elusive. Therefore, it necessary to elucidate new genotype–phenotype relationships for ASD improve both etiological knowledge and diagnosis. In this work, copy‐number variant whole‐exome sequencing analysis were performed in an patient complex neurobehavioral phenotype epilepsy attention deficit hyperactivity disorder. We identified rare recessive single...
Nowadays there is a debate about the indication of oral whole-cell/recombinant B-subunit cholera vaccine (WC/rBS) in traveller's diarrhoea. However, cost-benefit analysis based on real data has not been published. A cost-effectiveness and study (WC/rBS), Dukoral® for prevention diarrhoea (TD) was performed subjects travelling to risk areas. The effectiveness WC/rBS TD analyzed 362 travellers attending two International Vaccination Centres Spain between May September 2005. overall efficacy...
<ns4:p><ns4:bold>Background:</ns4:bold> Insulin resistance (IR) evaluation is a fundamental goal in clinical and epidemiological research. However, the most widely used methods are difficult to apply populations with low incomes. The triglyceride-glucose index (TGI) emerges as an alternative use daily practice. Therefore objective of this study was determine optimal cutoff point for TGI adult population from Maracaibo, Venezuela.</ns4:p><ns4:p> <ns4:bold>Methods:</ns4:bold> This sub-study...
Late preterm (LP) infants (34–36 weeks of gestation) are the largest group and also least studied so far. In order to improve their care reduce impact increased morbidity mortality, it is essential know current situation in Spain. Clinical-epidemiological variables LP population 34 participating hospitals were prospectively collected from April 1, 2011 March 31, 2016, then compared with Minimum Perinatal Data Set for term births database. Of 9,121 studied, 21.7% 34, 30.8% 35, 47.5% 36...
Abstract Background The efficacy of licensed direct-acting antiviral (DAA) regimens is assumed to be the same for hepatitis C virus (HCV)–monoinfected patients (HCV-Mono) and HIV/HCV-coinfected (HCV-Co). However, high sustained viral response (SVR) rates DAA small number HIV-infected included in registration trials have made it difficult identify predictors treatment failure, including presence HIV. Methods We compared outcomes ledipasvir/sofosbuvir (LDV/SOF) against HCV G1 treatment-naïve...