A5017388943- Sarcoma Diagnosis and Treatment
- Vascular Tumors and Angiosarcomas
- COVID-19 and healthcare impacts
- Cardiac tumors and thrombi
- Cutaneous Melanoma Detection and Management
- CAR-T cell therapy research
- Melanoma and MAPK Pathways
- Cardiac, Anesthesia and Surgical Outcomes
- Trauma and Emergency Care Studies
- Reconstructive Surgery and Microvascular Techniques
- Immunotherapy and Immune Responses
- Polyomavirus and related diseases
- Surgical site infection prevention
- Cancer and Skin Lesions
- Ear and Head Tumors
- Bone Tumor Diagnosis and Treatments
- Radiation Dose and Imaging
- Vascular Malformations and Hemangiomas
- Medical Imaging and Pathology Studies
- Antenna Design and Analysis
- Wound Healing and Treatments
- CNS Lymphoma Diagnosis and Treatment
- Ultrasound in Clinical Applications
- Neuroblastoma Research and Treatments
- Advances in Oncology and Radiotherapy
The Netherlands Cancer Institute
2021-2024
Oncode Institute
2023-2024
Dutch Cancer Society
2024
Society of Surgical Oncology
2023
Laboratoire des Sciences de l'Ingénieur, de l'Informatique et de l'Imagerie
2020-2022
University of Birmingham
2020-2021
NIHR Birmingham Biomedical Research Centre
2021
Yorkshire Cancer Research
2021
Urology Foundation
2021
Association for Cancer Surgery
2021
ObjectiveILP has shown to achieve high response rates in patients with melanoma ITM. Possibly there is a synergistic mechanism of action ILP and anti-PD1. The aim this trial was investigate the safety efficacy adding single dose systemic anti-PD1 isolated limb perfusion (ILP) for in-transit metastases (ITM).MethodsIn placebo controlled double-blind phase Ib/II trial, ITM were randomized 1:1 either nivolumab or one day prior ILP. primary endpoint complete (CR) rate at three months, terms...
The aim of this study was to assess the association between radiological and histopathological response after neoadjuvant radiotherapy (nRT) in soft tissue sarcoma (STS), as well prognostic value different evaluation methods on oncological outcome.A retrospective cohort patients with localized STS extremity trunk wall, treated nRT followed by resection were included. assessed RECIST 1.1 (RECIST) MR-adapted Choi (Choi), histopathologic evaluated according EORTC-STBSG recommendations....
Abstract Background Isolated limb infusion and perfusion (ILI/ILP) has been a mainstay treatment for unresectable melanoma in‐transit metastases (ITM), but increased use of immune checkpoint inhibitors (ICI) intralesional therapy (talimogene laherparepvec [TVEC]) introduced several different management options. This study compares first‐line ILI/ILP, ICI, TVEC. Methods Retrospective review from 12 international institutions included patients treated 1990 to 2022 with or TVEC ITM. Results A...
Purpose of the Report Localization techniques are needed to facilitate resection nonpalpable lesions. In this study, feasibility radio-guided occult lesion localization (ROLL) with 99m Tc is investigated for nonpalpable, small, suspicious, or proven melanoma soft tissue sarcoma lesions at various locations throughout body. Patients and Methods were selected study. Within 24 hours before surgery, a median dose 33.92 MBq Tc-labeled human albumin particles ( Tc-NA Tc-MAA) was injected in under...
This study assessed whether electromagnetic navigation can be of added value during resection recurrent or post-therapy intra-abdominal/pelvic soft tissue sarcomas (STS) in challenging locations.Patients were included a prospective study. A pre-operatively 3D roadmap was made and tracked using reference markers. During the operation, an pointer used for localization tumor/critical anatomical structures. The primary endpoint feasibility, secondary outcomes safety usability.Nine patients with...
Imaging is crucial in monitoring treatment effects soft tissue sarcoma (STS), where tumor size and intensity are key factors. Standard evaluation criteria, RECIST Choi, have been criticized for inconsistencies limited correlation with patient outcomes. While more accurate predicting response, Choi criteria labor intensive radiologists, necessitating improved methods. We analyzed Spearman correlations between diameter, volume. Cohen's kappa was used to measure agreement RECIST,...