A5015407323- Mechanical Circulatory Support Devices
- Cardiac Structural Anomalies and Repair
- Transplantation: Methods and Outcomes
- Heart Failure Treatment and Management
- Renal Transplantation Outcomes and Treatments
- Organ Transplantation Techniques and Outcomes
- Cardiac pacing and defibrillation studies
- Cardiac Arrest and Resuscitation
- Platelet Disorders and Treatments
- Congenital Heart Disease Studies
- Respiratory Support and Mechanisms
- Long-Term Effects of COVID-19
- Atrial Fibrillation Management and Outcomes
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Valve Diseases and Treatments
- Hemoglobin structure and function
- Venous Thromboembolism Diagnosis and Management
- Intensive Care Unit Cognitive Disorders
- Intracerebral and Subarachnoid Hemorrhage Research
- COVID-19 Clinical Research Studies
- Cardiac Arrhythmias and Treatments
- Cardiac Ischemia and Reperfusion
- Ultrasound and Hyperthermia Applications
- Hemophilia Treatment and Research
- Airway Management and Intubation Techniques
University of Freiburg
2014-2025
Universitäts-Herzzentrum Freiburg-Bad Krozingen
2014-2025
University Medical Center Freiburg
2007-2025
University Medical Center Hamburg-Eppendorf
2017
Roche (Switzerland)
2014
New Valve Technology (Germany)
2010
Edwards Lifesciences (Switzerland)
2010
Medtronic (China)
2010
Intuitive Surgical (Switzerland)
2010
CSL (Germany)
2010
Objective: Outcomes after ventricular assist device (VAD) implantation have significantly improved during the last decade. However, bleeding episodes remain a serious complication of VAD support. This cannot be explained by individual anticoagulation regimen alone in several cases, but may symptomatic acquired von Willebrand disease (VWD). The leading finding VWD (AVWD) is loss large multimers which results diminished binding to collagen and platelets. We, therefore, analysed patients with...
Abstract Background and Aims HeartMate 3 (HM3) is a fully magnetically levitated continuous flow left ventricular assist device, which received CE marking in 2015. The ELEVATE Registry was initiated to collect real-world outcomes patients treated with HM3 post-CE Mark approval. Methods A total of 540 subjects implanted at 26 centres between March 2015 February 2017 were included this registry. Of these, 463 the device as primary implant (primary cohort, PIC), 19 pump exchange (pump cohort),...
Abstract OBJECTIVES This fourth report aimed to provide insights into patient characteristics, outcomes, and standardized outcome ratios of patients implanted with durable Mechanical Circulatory Support across participating centers in the European Registry for Patients (EUROMACS) registry. METHODS All registered receiving mechanical circulatory support up August 2024 were included. Expected number events predicted using penalized logistic regression. Standardized (Observed/Expected events)...
Elevated pulmonary vascular resistance (PVR) unresponsive to pharmacological intervention is a major limitation in heart transplantation (HTX). The post-operative course of these patients associated with an increased risk life-threatening right failure. We evaluated the efficiency implantable left ventricular assist device (LVAD) decrease PVR by unloading ventricle and lower later orthotopic HTX.Six end-stage failure (NYHA class IV) 'fixed' hypertension (PVR 5.7+/-0.7, range 4.4-6.5 Wood...
Unexplained bleeding episodes are associated with ventricular assist devices (VAD) and can occur in part due to acquired von Willebrand syndrome (AVWS). AVWS is characterised by loss of high molecular weight (HMW) multimers factor (VWF) decreased ratios collagen binding capacity ristocetin cofactor activity VWF antigen. Loss as subjected increased shear stress, which occurs presence VADs. We studied 12 patients who required mechanical support their native heart for terminal cardiac...
Implantation of a ventricular assist device (VAD) is seminal therapeutic option for patients with terminal cardiac failure. However, haemolysis remains clinically relevant adverse effect several VAD types. Lysed erythrocytes release lactate dehydrogenase (LDH) and haemoglobin. Free haemoglobin in plasma bound by haptoglobin high affinity. The complex internalised monocytes/macrophages degraded. Any more released free captured haemopexin. This also undergoes lysosomal degradation various...
Objective: Acquired Von Willebrand syndrome (AVWS) can contribute to bleeding complications in patients with ventricular assist devices (VADs). AVWS results from shear stress, which causes unfolding of the high-molecular-weight (HMW) multimers factor (VWF) subsequent cleavage. Loss HMW VWF is leading finding AVWS. In consequence, binding collagen and platelets impaired. The onset after VAD implantation not yet determined. We examined for presence an early, intermediate, late phase...
Abstract Aims Heart transplantation may represent a particular risk factor for severe coronavirus infectious disease 2019 (COVID-19) due to chronic immunosuppression and frequent comorbidities. We conducted nation-wide survey of all heart transplant centers in Germany presenting the clinical characteristics recipients with COVID-19 during first months pandemic Germany. Methods results A multicenter evaluating current status among adult was performed. total 21 patients reported Mean patient...
The ELEVATE Registry was designed to study long-term outcomes with the Heartmate 3 (HM3), a fully magnetically levitated centrifugal ventricular assist device, in real-world population following CE-mark approval.A total of 540 patients, implanted Europe and Middle East were followed ELEVATE. registry included 463 patients receiving HM3 as primary implant (Primary Implant Cohort), 19 underwent pump upgrade from another device (Pump Exchange Cohort) 58 who had experienced an outcome before...
Abstract Background and Aims Given limited evidence lack of consensus on donor acceptance for heart transplant (HT), selection practices vary widely across HT centres in the USA. Similar variation likely exists a broader scale—across countries systems—but remains largely unexplored. This study characterized differences populations between USA Eurotransplant—a consortium eight European countries—and their implications system-wide outcomes. Methods Characteristics adult reported donors...
The number of implanted ventricular assist devices (VADs) has increased significantly recently. Bleeding, the most frequent complication, cannot be solely attributed to anticoagulation therapy. Acquired von Willebrand syndrome (AVWS) caused by shear stress is in VAD patients and can increase bleeding risk. HeartMate III (HM III) a novel left featuring potential improvements over II.In this study, we investigated prevalence onset AVWS 198 patients. To our knowledge, largest cohort whose...
Ex vivo organ perfusion is an advanced preservation technique that allows graft assessment and extended ex situ intervals. We hypothesized its properties might be especially beneficial for high-risk recipients and/or donors with criteria.We reviewed the outcomes of 119 consecutive heart transplant patients, which were divided into two groups: A (OCS) vs. B (conventional). was performed using Organ Care System (OCS). Indications OCS-usage expected ischemic time >4 h or >2 plus given donor...
Hypercoagulability in Coronavirus Disease 2019 (COVID-19) causes deep vein thrombosis and pulmonary embolism necessitating systemic anticoagulation. Case reports of intracerebral hemorrhages ventilated COVID-19 patients warrant precaution. It is unclear, however, if with acute respiratory distress syndrome (ARDS) or without veno-venous extracorporeal membrane oxygenation therapy (VV-ECMO) have more (ICH) compared to other ARDS patients.
Left ventricular assist device (LVAD) outflow graft obstruction (OGO) is a serious complication that often requires surgical intervention. Standard approaches involve cardiopulmonary bypass (CPB) or veno-arterial extracorporeal membrane oxygenation (vaECMO) to facilitate clamping and shortening. We present approach reduce the need for CPB vaECMO A 25-year-old female presented routine LVAD follow-up with reduced flow. Computed tomography angiography (CTA) revealed OGO due external compression...
Impaired binding of Von Willebrand factor (VWF) to platelets and collagen due acquired syndrome (AVWS) is associated with support from a ventricular assist device (VAD) can contribute bleeding tendencies in patients VADs. The onset AVWS has been shown occur immediately after VAD implantation. Our aim was determine long-term data on patients.We analysed 278 sets 74 HeartMate II (HMII) for 3-80 months implantation (11.2 ± 12.1, median 6.3 months.). Ristocetin cofactor activity (VWF:RCo),...
Objective: Both heart transplant (HTX) candidates and patients on ventricular assist device (VAD) support suffer from severe failure have to fear life-threatening complications. For both patient groups, the importance of screening for treatment psychosocial problems mental disorders optimize compliance survival has been acknowledged. We compared use psychotherapeutic by with primary HTX, VAD support, either destination therapy or be transplanted, successfully bridged transplant. In addition,...
With liberalization of donor eligibility criteria, hearts are being harvested from remote locations, increasing ischemic times. The aim this study was to examine the effect total time (TIT) on length stay in intensive care unit (LOS ICU) and its economic consequences. population included recipients without prior mechanical support undergoing heart transplantation between 1998 2008 at a single institution. mean age 72 (56 men, 16 women) 50.6 years (range 15-68 years) 41.5 11-61 years). median...