Erwan Flécher
A5040091356- Mechanical Circulatory Support Devices
- Cardiac Structural Anomalies and Repair
- Infective Endocarditis Diagnosis and Management
- Cardiac Valve Diseases and Treatments
- Cardiac Arrest and Resuscitation
- Transplantation: Methods and Outcomes
- Aortic Disease and Treatment Approaches
- Cardiac pacing and defibrillation studies
- Heart Failure Treatment and Management
- Antimicrobial Resistance in Staphylococcus
- Cardiac, Anesthesia and Surgical Outcomes
- Organ Transplantation Techniques and Outcomes
- Cardiac and Coronary Surgery Techniques
- Orthopedic Infections and Treatments
- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Infectious Aortic and Vascular Conditions
- Congenital Heart Disease Studies
- Renal Transplantation Outcomes and Treatments
- Healthcare Systems and Practices
- Viral Infections and Immunology Research
- Intensive Care Unit Cognitive Disorders
- Respiratory Support and Mechanisms
- Coronary Interventions and Diagnostics
- Pulmonary Hypertension Research and Treatments
Centre Hospitalier Universitaire de Rennes
2016-2025
Université de Rennes
2016-2025
Hôpital Pontchaillou
2015-2024
Inserm
2013-2024
Paris Biotech Santé
2023
Laboratoire Traitement du Signal et de l'Image
2015-2023
Chongqing Electromechanical Holdings (China)
2022
Association Française pour le Dépistage et la Prévention des Handicaps de l’Enfant
2022
Méditerranée Infection Foundation
2022
Institut de Recherche pour le Développement
2022
The aim of this article is to assess the left atrial (LA) reservoir function in patients with severe aortic stenosis (AS) and evaluate its impact on recurrence major adverse cardiac events (MACEs). About 128 (mean age 79 ± 9 years) AS were included study. Global peak LA strain (PLAS) measured by two-dimensional speckle-tracking echocardiography (STE) during ventricular (LV) systole represented function. Overall death, hospitalization for cause, worsening heart failure defined as MACEs. With...
The optimal approach to the use of venoarterial extracorporeal membrane oxygenation (ECMO) during cardiogenic shock is uncertain.To determine whether early moderate hypothermia (33-34 °C) compared with strict normothermia (36-37 improves mortality in patients receiving ECMO.Randomized clinical trial (who were eligible if they had been endotracheally intubated and ECMO for <6 hours) conducted intensive care units at 20 French cardiac centers between October 2016 July 2019. Of 786 patients,...
Background Extracorporeal membrane oxygenation (ECMO) has been increasingly used for postcardiotomy cardiogenic shock, but without a concomitant reduction in observed in-hospital mortality. Long-term outcomes are unknown. This study describes patients' characteristics, outcome, and 10-year survival after ECMO. Variables associated with postdischarge mortality investigated reported. Methods Results The retrospective international multicenter observational PELS-1 (Postcardiotomy Life Support)...
Background Unfractionated heparin, administered during venoarterial extracorporeal membrane oxygenation to prevent thromboembolic events, largely depends on plasma antithrombin for its antithrombotic effects. Decreased heparin responsiveness seems frequent oxygenation; however, association with acquired deficiency is poorly understood. The objective of this study was describe longitudinal changes in levels support and evaluate the between responsiveness. hypothesis that would be associated...
Venoarterial extracorporeal membrane oxygenation (VA-ECMO) is increasingly used as a short-term circulatory support in patients with refractory cardiogenic shock providing bridge to long-term mechanical or transplantation. In France, higher priority status granted transplant candidates on VA-ECMO than those support. This study aimed evaluate the impact of transplantation primary therapy survival at listing.This was retrospective analysis data from French national registry CRISTAL including...
// Murielle Grégoire 1,2,3 , Fabien Guilloton Céline Pangault 1,2,3,4 Frédéric Mourcin Phaktra Sok 1,2,3,5 Maelle Latour 3,4 Patricia Amé-Thomas Erwan Flecher 6 Thierry Fest and Karin Tarte 1 INSERM, UMR U917, Equipe Labellisée Ligue Contre le Cancer, Rennes, France 2 Université Rennes 1, UMR917, 3 EFS Bretagne, 4 CHU de Pôle Biologie, 5 Service Médecine L'enfant et L'adolescent, Chirurgie Thoracique Cardiovasculaire, Correspondence to: Tarte, email: Keywords : B-cell lymphoma, tumor...
Background Despite expanding use, knowledge on extracorporeal membrane oxygenation support during the COVID-19 pandemic remains limited. The objective was to report characteristics, management, and outcomes of patients receiving with a diagnosis in France identify pre-extracorporeal factors associated in-hospital mortality. A hypothesis similar mortality rates risk for non–COVID-19 venovenous made. Methods Extracorporeal Membrane Oxygenation Respiratory Failure and/or Heart failure related...
To describe the clinical results (both early and at follow-up) of patients currently receiving extracorporeal membrane oxygenation (ECMO) therapy for cardiac and/or pulmonary failure. assess effect indications, presentations ECMO modalities on early/late outcomes. identify baseline factors associated with worse survival follow-up.We reviewed prospectively collected data 325 a tertiary referral centre during 2005-2013 period. Follow-up was conducted by dedicated personnel (average: 84 ± 86...
Post-cardiotomy cardiogenic shock is a major concern in cardiac surgery. We reviewed our experience of extracorporeal membrane oxygenation (ECMO) as temporary circulatory support post-cardiotomy shock.Between January 2005 and December 2014, adult patients implanted with ECMO after surgical procedures were included. Indications for failure to be withdrawn from cardiopulmonary bypass or refractory occurring during postoperative Days 1 2. Patients' characteristics outcomes prospectively...
To better select for patients who most likely will benefit from cardiac surgery among those with infective endocarditis (IE), we aimed to identify preoperative markers associated poor outcome after IE, and evaluate the accuracy of European System Cardiac Operative Risk Evaluation (EuroSCORE) II predict mortality. We enrolled all adult underwent during acute phase definite IE (Duke Criteria) in two referral centres surgery. Patients were identified through intensive care unit (ICU) electronic...
Venoarterial extracorporeal membrane oxygenation (VA-ECMO) provides heart mechanical support in critically ill patients with cardiogenic shock. Despite important progresses the management of under VA-ECMO, acquired infections remain extremely frequent and increase mortality rate. Since immune dysfunctions have been described both after surgery cardiopulmonary bypass, VA-ECMO initiation may be responsible for alterations that expose to nosocomial (NI). Therefore, this prospective study, we...
OBJECTIVES: Prone positioning and venovenous extracorporeal membrane oxygenation (ECMO) are both useful interventions in acute respiratory distress syndrome (ARDS). Combining the two therapies is feasible safe, but effectiveness not known. Our objective was to evaluate potential survival benefit of prone ECMO patients cannulated for COVID-19–related ARDS. DESIGN: Retrospective analysis a multicenter cohort. PATIENTS: Patients on who tested positive severe coronavirus 2 by reverse...
ObjectivesPostcardiotomy extracorporeal membrane oxygenation (ECMO) can be initiated intraoperatively or postoperatively based on indications, settings, patient profile, and conditions. The topic of implantation timing only recently gained attention from the clinical community. We compare characteristics as well in-hospital long-term survival between intraoperative postoperative ECMO.MethodsThe retrospective, multicenter, observational Postcardiotomy Extracorporeal Life Support (PELS-1)...
Abstract Background Both critically ill patients with coronavirus disease 2019 (COVID-19) and receiving extracorporeal membrane oxygenation (ECMO) support exhibit a high incidence of healthcare-associated infections (HAI). However, data on incidence, microbiology, resistance patterns, the impact HAI outcomes in ECMO for severe COVID-19 remain limited. We aimed to report microbiology evaluate ECMO-associated (ECMO-AI) in-hospital mortality. Methods For this study, we analyzed from 701...
The new French heart allocation system is designed to minimize waitlist mortality and extend the donor pool without a detrimental effect on posttransplant survival. This study was construct 1-year graft-loss risk score incorporating recipient characteristics. included all adult first single-organ recipients transplanted between 2010 2014 (N = 1776). population randomly divided in 2:1 ratio into derivation validation cohorts. association of variables with graft loss determined mixed Cox model...
Extracorporeal life support is used for patients with severe heart failure as a bridge to transplantation or recovery. We aimed at analyzing the efficacy and safety of extracorporeal treat refractory arrhythmic storm responsible cardiogenic shock in resistant antiarrhythmic drugs.Retrospective study.University Hospital Rennes, France.Patients admitted between January 2005 March 2015.Patients intractable despite optimal medical therapy were implanted an support. Patients' characteristics...