A5074281561- COVID-19 Clinical Research Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Respiratory Support and Mechanisms
- Long-Term Effects of COVID-19
- Intracranial Aneurysms: Treatment and Complications
- Mechanical Circulatory Support Devices
- Intracerebral and Subarachnoid Hemorrhage Research
- Cancer, Hypoxia, and Metabolism
- Heart Failure Treatment and Management
- Cardiovascular Syncope and Autonomic Disorders
- Magnetic Bearings and Levitation Dynamics
- Tribology and Lubrication Engineering
- Cardiac Structural Anomalies and Repair
- Intensive Care Unit Cognitive Disorders
- Hydraulic and Pneumatic Systems
- Trauma Management and Diagnosis
- Pleural and Pulmonary Diseases
- Eicosanoids and Hypertension Pharmacology
- Vascular anomalies and interventions
- Sepsis Diagnosis and Treatment
- Laser Applications in Dentistry and Medicine
- Pneumonia and Respiratory Infections
- Infrared Thermography in Medicine
- Blood groups and transfusion
- Kawasaki Disease and Coronary Complications
Aix-Marseille Université
2017-2023
Hôpital de la Timone
2019-2023
Inserm
2023
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2023
Hôpital Privé Marseille Beauregard
2022-2023
Hôpital de la Conception
2022
Assistance Publique Hôpitaux de Marseille
2021-2022
Unité de recherche sur les maladies cardiovasculaires et métaboliques
2019
The optimal approach to the use of venoarterial extracorporeal membrane oxygenation (ECMO) during cardiogenic shock is uncertain.To determine whether early moderate hypothermia (33-34 °C) compared with strict normothermia (36-37 improves mortality in patients receiving ECMO.Randomized clinical trial (who were eligible if they had been endotracheally intubated and ECMO for <6 hours) conducted intensive care units at 20 French cardiac centers between October 2016 July 2019. Of 786 patients,...
Since March 2020, health care systems were importantly affected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak, with some patients presenting distress (ARDS), requiring extra-corporeal membrane oxygenation (ECMO). We designed an ambispective observational cohort study including all consecutive adult admitted to 5 different ICUs from a university hospital. The main objective was identify the risk factors of COVID-19 ARDS supported ECMO associated 90-day survival.
Describe the characteristics of ventilation-acquired pneumonia (VAP) and potential risk factors in critically ill SARS-CoV-2 patients admitted three French public hospitals during first year COVID-19 pandemic. We conducted a monocentric retrospective study seven Marseille intensive care units (ICUs) aiming to describe VAP identify their factors. were compared non-VAP control group. From March November 2020, 161 for viral-induced acute respiratory failure (ARF) requiring invasive mechanical...
Restrictive anorexia nervosa (AN) presents an adaptive appetite regulating profile including mainly high levels of ghrelin. Because this mechanism is not effective on food intake, other appetite-regulating peptides need to be explored. 26RFa a hypothalamic neuropeptide that stimulates appetite, gonadotropin release, and bone metabolism. The objective the study was evaluate circadian in AN patients compared with healthy subjects, eating disorders, constitutional thinness (CT). This...
Following the results of randomized controlled trials on levosimendan, French health authorities requested an update current use and side-effects this medication a national scale.The France-LEVO registry was prospective observational cohort study reflecting indications, dosing regimens, as well patient outcomes over year.The patients included (n = 602) represented 29.6% yearly levosimendan in France. They were treated for cardiogenic shock 250, 41.5%), decompensated heart failure 127,...
Background: Acute kidney injury (AKI) is the second most frequent condition after acute respiratory distress syndrome (ARDS) in critically ill patients with severe COVID-19 and strongly associated mortality. The aim of this multicentric study was to assess impact specific treatments ARDS on risk AKI patients. Methods: In cohort study, data from consecutive older than 18 years admitted 6 ICUs for COVID-19-related requiring invasive mechanical ventilation were included. incidence severity AKI,...
Delayed cerebral ischemia (DCI) following aneurysmal subarachnoid hemorrhage (aSAH) is a major cause of complications and death. Here, we set out to identify high-performance predictive biomarkers DCI its underlying metabolic disruptions using metabolomics lipidomics approaches. This single-center prospective observational study enrolled 61 consecutive patients with severe aSAH; among them, 22 experienced DCI. Nine without aSAH were included as validation controls. Blood cerebrospinal fluid...
In order to avoid contact between the vibrating rotor and stator, annular seals are designed with a relatively large radial clearance (∼100 μm) and, therefore, have an important leakage. The floating ring seal is able reduce leakage flow rate by using much lower clearance. as on in accommodate its vibrations. pressure difference upstream downstream chambers pressing nose of (secondary seal) against stator. forces acting resultant hydrodynamic field inside primary seal, friction secondary...
Several lipid metabolites in cerebrospinal fluid are correlated with poor outcomes aneurysmal subarachnoid haemorrhage. Most of these bind to ubiquitous thromboxane-prostaglandin (TP) receptors, causing vasoconstriction and inflammation. Here, we evaluated terutroban (TBN), a specific TP receptor antagonist, for the prevention post-haemorrhage blood-brain barrier disruption, neuronal apoptosis delayed cerebral hypoperfusion.The rat double haemorrhage model was produced by twice injecting...
To describe clinical characteristics and management of intensive care units (ICU) patients with laboratory-confirmed COVID-19 to determine 90-day mortality after ICU admission associated risk factors.This observational retrospective study was conducted in six (ICUs) three university hospitals Marseille, France. Between 10 March May 2020, all adult admitted SARS-CoV-2 respiratory failure were eligible for inclusion. The statistical analysis focused on the mechanically ventilated patients....
A novel multisystem inflammatory syndrome in children (MIS-C) temporally associated with the coronavirus disease 2019 (COVID-19) infection has been reported, arising weeks after peak incidence of COVID-19 adults. Patients MIS-C have reported to cardiac involvement and clinical features overlapping other acute syndromes such as Kawasaki disease, toxic shock syndrome, macrophage activation syndrome. Multisystem may follow infection, most time its asymptomatic form, even though it can lead...
Abstract BackgroundKidney failure is the second most frequent condition after acute respiratory distress syndrome (ARDS) in critically ill patients with severe COVID-19 and strongly associated mortality. The aim of this multicentric study was to assess impact specific treatments ARDS on risk kidney injury (AKI) patients.MethodsIn cohort study, data from consecutive hospitalized 6 ICUs for were retrospectively collected. incidence severity AKI monitored during entire ICU stay. Patients older...
Abstract Introduction: Non-life-threatening blunt chest trauma (BCT) admitted in emergency department (ED) are at risk of acute respiratory failure (ARF) and complications during their intensive care unit (ICU) follow-up. They may require a special focus to adopt specific prophylactic strategies proper orientation. The aim this study was identify different factors for ARF mild BCT. Methods: This retrospective, monocentric from January 2015 December 2020 included all patients with BCT the ED...
Functional isotope imaging evaluation of terutroban efficiency in a proinflammatory rat model subarachnoid haemorrhage (SAH)
Abstract BACKGROUND Delayed cerebral ischaemia (DCI) following aneurysmal subarachnoid haemorrhage (aSAH) is a major cause of complications and death. Here we set out to identify high-performance predictive biomarkers DCI its underlying metabolic disruptions using metabolomics lipidomics approaches. METHODS This single-centre retrospective observational study enrolled 61 consecutive patients with severe aSAH requiring external ventricular drainage between 2013 2016. Of these patients, 22...
Abstract BACKGROUND. Delayed cerebral ischaemia (DCI) following aneurysmal subarachnoid haemorrhage (aSAH) is a major cause of complications and death. Here we set out to identify high-performance predictive biomarkers DCI its underlying metabolic disruptions using metabolomics lipidomics approaches. METHODS. This single-centre retrospective observational study enrolled 61 consecutive patients with severe aSAH requiring external ventricular drainage between 2013 2016, among them 22...
In order to avoid contact between the vibrating rotor and stator annular seals are designed with a relatively large radial clearance (∼100 μm) therefore have an important leakage. The floating ring seal is able reduce leakage flow rate by using much lower clearance. as on in accommodate its vibrations. pressure difference upstream downstream chambers pressing nose of (secondary seal) against stator. forces acting resultant hydrodynamic field inside primary seal, friction secondary inertia...
Abstract BACKGROUND AND AIMS Kidney failure is the second most frequent condition after acute respiratory distress syndrome (ARDS) in critically ill patients with severe COVID-19 and strongly associated mortality. The aim of this multicentric study was to assess impact specific treatments ARDS on risk kidney injury (AKI) COVID patients. METHOD Data from a prospectively collected database consecutive hospitalized six ICUs for retrospectively analysed. incidence severity AKI were monitored...
Abstract Introduction The aim of this study was to evaluate if an automated measurement lung lesions, epicardial fat and pericardial volume during the days surrounding hospital admission for COVID-19 pneumonia may predict intubation or mortality. second purpose assess whether association these Computed Tomography (CT) measures with SOFA (Sequential Organ Failure Assessment) score, could mortality better than score alone. Methods This observational retrospective conducted in Timone university...