A5069803353- Mechanical Circulatory Support Devices
- Cardiac Valve Diseases and Treatments
- Cardiac Structural Anomalies and Repair
- Cardiac Arrest and Resuscitation
- Aortic Disease and Treatment Approaches
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Ischemia and Reperfusion
- Infective Endocarditis Diagnosis and Management
- Atrial Fibrillation Management and Outcomes
- Cardiac and Coronary Surgery Techniques
- Venous Thromboembolism Diagnosis and Management
- Heart Failure Treatment and Management
- Transplantation: Methods and Outcomes
- Cardiovascular Function and Risk Factors
- Antiplatelet Therapy and Cardiovascular Diseases
- Mitochondrial Function and Pathology
- Cardiac Imaging and Diagnostics
- Cardiac pacing and defibrillation studies
- Aortic aneurysm repair treatments
- Enhanced Recovery After Surgery
- Anesthesia and Neurotoxicity Research
- Cardiovascular and exercise physiology
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Congenital Heart Disease Studies
- Extracellular vesicles in disease
Mitochondrie, stress oxydant et protection musculaire
2013-2025
Hôpital Civil, Strasbourg
2015-2025
Hôpitaux Universitaires de Strasbourg
2014-2024
Université de Strasbourg
2014-2024
Médecine Cardiovasculaire Translationnelle
2024
Université de Rennes
2022
Centre Hospitalier Universitaire de Rennes
2022
Inserm
2022
Laboratoire de Biométrie et Biologie Evolutive
2016
NorthEast Regional Epilepsy Group
2016
Statins protect against cardiovascular-related mortality but induce skeletal muscle toxicity. To investigate mechanisms of statins, we tested the hypothesis that statins optimized cardiac mitochondrial function impaired vulnerable by inducing different level reactive oxygen species (ROS). In atrium patients treated with ROS production was decreased and oxidative capacities were enhanced together an extensive augmentation mRNAs expression peroxisome proliferator-activated receptor gamma...
The optimal approach to the use of venoarterial extracorporeal membrane oxygenation (ECMO) during cardiogenic shock is uncertain.To determine whether early moderate hypothermia (33-34 °C) compared with strict normothermia (36-37 improves mortality in patients receiving ECMO.Randomized clinical trial (who were eligible if they had been endotracheally intubated and ECMO for <6 hours) conducted intensive care units at 20 French cardiac centers between October 2016 July 2019. Of 786 patients,...
To provide recommendations for enhanced recovery after cardiac surgery (ERACS) based on a multimodal perioperative medicine approach in adult patients with the aim of improving patient satisfaction, reducing postoperative mortality and morbidity, length hospital stay.A consensus committee 20 experts from French Society Anaesthesia Intensive Care Medicine (Société française d'anesthésie et de réanimation, SFAR) Thoracic Cardiovascular Surgery chirurgie thoracique cardio-vasculaire, SFCTCV)...
The present study was designed to describe the prevalence of norepinephrine use, factors associated with its and incidence postoperative complications according in patients undergoing cardiac surgery cardiopulmonary bypass.We performed a prospective, multicenter, observational 4 University-affiliated medico-surgical cardiovascular units. We analyzed all treated after excluding pre-ECMO surgery, LVAD implantation, heart transplantation intra-operative hemorrhage.Of 9316 screened during...
Delta 9 tetrahydrocannabinol (THC), the main component of cannabis, has adverse effects on cardiovascular system, but whether concomitant ethanol (EtOH) and aging modulate its toxicity is unknown. We investigated dose responses THC vehicle, EtOH, mitochondrial respiration reactive oxygen production in both young old rat cardiac mitochondria (12 90 weeks). dose-dependently impaired groups, such impairment was enhanced aged rats (−97.5 ± 1.4% vs. −75.6 4.0% at 2 × 10−5 M, IC50: 0.7 0.05 1.3...
Muscle injury resulting from ischemia-reperfusion largely aggravates patient prognosis but whether and how muscle phenotype modulates ischemia-reperfusion-induced mitochondrial dysfunction remains to be investigated. We challenged the hypothesis that glycolytic muscles are more prone than oxidative skeletal muscles. therefore determined simultaneously effect of 3 hours ischemia induced by aortic clamping followed 2 reperfusion (IR, n=11) on both gastrocnemius soleus muscles, as compared...
Abstract OBJECTIVES The aim of this study was to assess the safety early chest tube removal (CTR) protocol on 1st postoperative day (POD1) our Enhanced Recovery After Surgery (ERAS) programme by comparing risk pneumothorax, pleural and pericardial effusion requiring intervention hospital mortality. METHODS All consecutive patients undergoing elective coronary revascularization and/or valve surgery between 2015 2021 were assessed in terms their perioperative management pathways: conventional...
Pathological tissues release a variety of factors, including extracellular vesicles (EVs) shed by activated or apoptotic cells. EVs trapped within the native pathological valves may act as key mediators valve thrombosis. Human aortic stenosis promote activation valvular endothelial cells, leading to dysfunction, and proadhesive procoagulant responses.
Abstract OBJECTIVES This study provides a thorough analysis of cardiac surgeons' involvement in transcatheter aortic valve replacement (TAVR) activities France, covering decision-making, procedural roles, training, and outcome analysis. METHODS A nationwide survey was sent to all surgeons surgery trainees France. Subgroup performed for age, status (established versus in-training), type practice facility. RESULTS total 172 from both private public sectors responded the survey. Most...
Background/Objectives: Acute respiratory distress syndrome (ARDS) is a life-threatening condition that frequently complicates high-risk cardiac surgery. We evaluated the circulating levels and transpulmonary gradient of intracellular proteins in patients at risk developing ARDS after surgery using large scale-proteomics. Methods: enrolled sixteen undergoing surgery, followed by planned ICU admission. Circulating were measured onset surgical procedure, admission (H0), 24 h (H24) blood samples...
Abstract Aims Heart transplantation (HT) can be proposed as a therapeutic strategy for patients with severe refractory electrical storm (ES). Data in the literature are scarce and based on case reports. We aimed at determining characteristics survival of transplanted ES. Methods results Patients registered HT waiting list during following days after ES eventually transplanted, from 2010 to 2021, were retrospectively included 11 French centres. The primary endpoint was in-hospital mortality....
Remote organ impairments are frequent and increase patient morbidity mortality after lower limb ischemia-reperfusion (IR). We challenged the hypothesis that IR might also impair lung, renal, liver mitochondrial respiration. Two-hour tourniquet-induced ischemia was performed on both hindlimbs, followed by a two-hour reperfusion period in C57BL6 mice. Lungs, kidneys maximal respiration (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"...
Despite growing evidence that aortic valve repair improves long-term patient outcomes and quality of life, valves are mostly replaced. We evaluate the effect versus replacement in patients with dystrophic root aneurysm up to 4 years.The multicentric CAVIAAR (Conservation Aortique Valvulaire dans les Insuffisances Aortiques et Anévrismes de la Racine aortique) prospective cohort study enrolled 261 patients: 130 underwent standardized (REPAIR) consisting remodelling expansible ring...
Evidence regarding the benefits of an enhanced recovery after cardiac surgery (ERACS) programme is lacking. The aim this study was to analyse impact a systematic standardized ERACS for patients undergoing isolated elective surgical aortic valve replacement (SAVR) stenosis in terms hospital mortality and morbidity, patient blood management length stay.Patients SAVR between 2015 2020 were identified from our database (n = 941). implemented November 2018. Propensity score matching indicated...
Abstract Aims Right ventricular failure after left assist device (LVAD) implantation is a major concern that remains challenging to predict. We sought investigate the relationship between preoperative pulmonary artery pulsatility index (PAPi) and mortality LVAD implantation. Methods results A retrospective analysis of ASSIST‐ICD multicentre registry allowed assessment PAPi before according formula [(systolic pressure − diastolic pressure)/central venous pressure]. The primary endpoint was...