A5028697974- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Atrial Fibrillation Management and Outcomes
- Cardiac pacing and defibrillation studies
- Muscle metabolism and nutrition
- Immune cells in cancer
- Cardiovascular Effects of Exercise
- Diet and metabolism studies
- Bone health and treatments
- Immune Response and Inflammation
- Ion channel regulation and function
- High Altitude and Hypoxia
- Clinical practice guidelines implementation
- Psychoanalysis and Psychopathology Research
- Mitochondrial Function and Pathology
- Methemoglobinemia and Tumor Lysis Syndrome
- Pain Management and Placebo Effect
- Congenital Heart Disease Studies
- Connective tissue disorders research
- Orthopedic Surgery and Rehabilitation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cardiovascular and exercise physiology
- Sepsis Diagnosis and Treatment
- RNA and protein synthesis mechanisms
- Musculoskeletal synovial abnormalities and treatments
Hôpital Cardiologique du Haut-Lévêque
2023-2025
Electrophysiology and Heart Modeling Institute
2023-2025
Bordeaux Population Health
2019-2025
Centre Hospitalier Universitaire de Bordeaux
2023-2025
Université de Bordeaux
2019-2025
Lille’s Cardiology Hospital
2025
Inserm
1988-2023
Centre de Recherche Cardio-Thoracique de Bordeaux
2023
Institut du Thorax
2020-2023
Université Paris Cité
2021-2022
Arrhythmogenic right ventricular cardiomyopathy (ARVC) causes arrhythmias (VAs) and sudden cardiac death (SCD). In 2019, a risk prediction model that estimates the 5-year of incident VAs in ARVC was developed (ARVCrisk.com). This study aimed to externally validate this large international multicentre cohort compare its performance with factor approach recommended for implantable cardioverter-defibrillator (ICD) use by published guidelines expert consensus.In retrospective 429 individuals...
Background: Recurrences of atrial fibrillation (AF) after pulmonary vein isolation (PVI) are mainly due to reconnection. However, a growing number patients have AF recurrences despite durable PVI. The optimal ablative strategy for these is unknown. We analyzed the impact current ablation strategies in large multicenter study. Methods: Patients undergoing redo and presenting PVI were included. freedom from arrhythmia vein-based, linear-based, electrogram-based, trigger-based compared....
Significance Statement The pathophysiology of AKI during tumor lysis syndrome (TLS) is not fully understood. We aimed to decipher crystal-dependent and crystal-independent mechanisms TLS-induced AKI. Analyzing urine blood from patients with TLS provided data on the pathogenesis TLS. also explored in vitro vivo a murine model (syngeneic mice acute myeloid leukemia receiving chemotherapy). found that extracellular histones released huge amounts profoundly alter endothelium. Nonanticoagulant...
Abstract Aim Ventricular arrhythmias (VAs) are the most common cause of death in patients with repaired Tetralogy Fallot (rTOF). However, risk stratifying remains challenging. We examined outcomes following programmed ventricular stimulation (PVS) or without subsequent ablation rTOF planned for pulmonary valve replacement (PVR). Methods included all consecutive referred to our institution from 2010 2018 aged ≥18 years PVR. Right (RV) voltage maps were acquired and PVS was performed two...
Abstract Aims Heart transplantation (HT) can be proposed as a therapeutic strategy for patients with severe refractory electrical storm (ES). Data in the literature are scarce and based on case reports. We aimed at determining characteristics survival of transplanted ES. Methods results Patients registered HT waiting list during following days after ES eventually transplanted, from 2010 to 2021, were retrospectively included 11 French centres. The primary endpoint was in-hospital mortality....
The role of elevated plasma epinephrine concentrations in the regulation leucine kinetics and contribution beta-receptors were assessed man. Epinephrine (50 ng/kg per min) was infused either alone or combined with propranolol (beta-blockade) into groups six subjects fasted overnight; flux, oxidation, net forearm balance determined during 180 min. Constant insulin glucagon maintained all studies by infusing somatostatin replacements. Plasma decreased from baseline infusion 27 +/- 5...
Summary. The effects of acute pH changes on whole body leucine kinetics (1‐ 13 C‐leucine infusion technique) were determined in normal subjects. Plasma insulin, glucagon, and growth hormone concentrations kept constant by somatostatin replacement infusions the three hormones. When acidosis was produced ingestion NH4CI (4 mmol kg ‐1 p. os; n = 8 ) arterialized decreased within 3 h from 7.39±0.01 to 7.31 ±0.01 (P<0.001) plasma appearance increased 0.13 ±0.04 μmol min (P<0.02); contrast,...
Background: Pulsed field ablation (PFA) is a novel technique for pulmonary vein isolation in atrial fibrillation management. Notably, asystole episodes of varying durations have been observed during electroporation, but the underlying mechanisms remain unclear. Objective: This study hypothesizes that PFA attributable to activation parasympathetic ganglia on left atrium’s surface. Methods: We conducted with 24 patients (67% male, 62.8 ± 11.0 years, BMI: 25.3 5.6) suffering from paroxysmal...
Patients receiving cytoreductive therapy and bone marrow transplantation (BMT) are known to develop marked protein catabolism. To assess the contribution of whole body breakdown, amino acid oxidation incorporation into proteins, plasma leucine kinetics (1‐ 13 C‐leucine infusion technique) were determined in six patients five times within 14 days before after (Cyclophosphamide total irradiation) transplantation. Nitrogen balance became negative (—0.20 ± 0.04 g/ Kg/24 hr) cyclophosphamide (p...