Alessio Gasperetti
A5020242367- Cardiac Arrhythmias and Treatments
- Cardiovascular Effects of Exercise
- Cardiac pacing and defibrillation studies
- Cardiac electrophysiology and arrhythmias
- Atrial Fibrillation Management and Outcomes
- Sports injuries and prevention
- Cardiomyopathy and Myosin Studies
- Viral Infections and Immunology Research
- Cardiac Imaging and Diagnostics
- Cardiac Arrest and Resuscitation
- COVID-19 Clinical Research Studies
- Cardiac Structural Anomalies and Repair
- Cardiac tumors and thrombi
- Cardiovascular Function and Risk Factors
- Congenital Heart Disease Studies
- Acute Myocardial Infarction Research
- Cardiac Valve Diseases and Treatments
- Heart Failure Treatment and Management
- Cardiovascular and exercise physiology
- COVID-19 and healthcare impacts
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Long-Term Effects of COVID-19
- Respiratory Support and Mechanisms
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Infective Endocarditis Diagnosis and Management
Johns Hopkins Medicine
2021-2025
Johns Hopkins University
2021-2025
Luigi Sacco Hospital
2019-2025
Centro Cardiologico Monzino
2018-2025
University of Padua
2024
Johns Hopkins Hospital
2021-2024
ASST Fatebenefratelli Sacco
2020-2024
Marche Polytechnic University
2020-2024
Utrecht University
2023-2024
University Medical Center Utrecht
2022-2024
Pathogenic desmoplakin (DSP) gene variants are associated with the development of a distinct form arrhythmogenic cardiomyopathy known as DSP cardiomyopathy. Patients harbouring these at high risk for sustained ventricular arrhythmia (VA), but existing tools individualized arrhythmic assessment have proven unreliable in this population.
Patients with likely pathogenic/pathogenic desmoplakin (
Background: Cryoballoon-based pulmonary vein isolation (PVI) has emerged as an effective treatment for atrial fibrillation. The most frequent complication during cryoballoon-based PVI is phrenic nerve injury (PNI). However, data on PNI are scarce. Methods: YETI registry a retrospective, multicenter, and multinational evaluating the incidence, characteristics, prognostic factors recovery follow-up of patients with PVI. Experienced electrophysiological centers were invited to participate. All...
Background: Electroanatomic voltage mapping (EVM) is a promising modality for guiding endomyocardial biopsies (EMBs). However, few data support its feasibility and safety. We now report the largest cohort of patients undergoing EVM-guided EMBs to show diagnostic yield compare it with cardiac magnetic resonance (CMR)–guided approach. Methods: included 162 consecutive EMB at our institution from 2010 2019. was performed in pathological areas identified EVM CMR. CMR sensitivity specificity...
Desmoplakin (DSP) cardiomyopathy is an increasingly recognized form of arrhythmogenic cardiomyopathy. With a genotype-specific approach, we characterized the diagnosis, natural history, and risk for ventricular arrhythmia heart failure in DSP cardiomyopathy.We followed 91 individuals [45 probands, 34% male, median age 27.5 years (interquartile interval 20.0-43.9)] with pathogenic or likely variants 4.3 years. Regarding involvement, left predominance was most common (n = 22, 28%) by...
BACKGROUND: In the early stages of COVID-19 pneumonia, hypoxemia has been described in absence dyspnea ("silent" or "happy" hypoxemia). Our aim was to report its prevalence and outcome a series hypoxemic patients upon Emergency Department admission.METHODS: this retrospective observational cohort study we enrolled population consisting 213 with PaO2/FiO2 ratio <300 mmHg at hospital admission. Two groups (silent dyspneic hypoxemia) were defined. Symptoms, blood gas analysis, chest X-ray (CXR)...
Hypothesizing that the non-aerated lung fraction as evaluated by quantitative analysis of computed tomography (CT) equals shunt (V A /Q = 0), we used a computational approach to estimate magnitude ventilation–perfusion mismatch in severe COVID-19. The results show hyperperfusion poorly ventilated region is likely cause hypoxemia observed. extensive microthrombosis pulmonary circulation may represent pathophysiological mechanism such V distribution.
Arrhythmogenic right ventricular cardiomyopathy (ARVC) causes arrhythmias (VAs) and sudden cardiac death (SCD). In 2019, a risk prediction model that estimates the 5-year of incident VAs in ARVC was developed (ARVCrisk.com). This study aimed to externally validate this large international multicentre cohort compare its performance with factor approach recommended for implantable cardioverter-defibrillator (ICD) use by published guidelines expert consensus.In retrospective 429 individuals...
Abstract Aims Pulsed field ablation (PFA) is a non-thermal ablative approach in which cardiomyocyte death obtained through irreversible electroporation (IRE). Data correlating the biophysical characteristics of IRE and lesion are limited. The aim this study was to assess effect different procedural parameters [voltage, number cycles (NoCs), contact] on vegetal animal model for IRE. Methods results Two hundred four Russet potatoes were used. lesions delivered 3 cm cored potato specimens using...
The feasibility and effectiveness of virtual visits (VVs) for cardiac electrophysiology patients are still unknown. We aimed to assess the VVs as compared in-person visits, describe patient experience with care in clinical electrophysiology. prospectively enrolled scheduled receive a evaluation, dividing them two groups: VV group an visit group. Outcomes interest were: (1) improvement symptoms after index visit, (2) disappearance remote monitoring (RM) alerts at follow-up, (3) necessity...
Abstract Background and Aims Implantable cardioverter-defibrillators (ICDs) are critical for preventing sudden cardiac death (SCD) in arrhythmogenic right ventricular cardiomyopathy (ARVC). This study aims to identify cross-continental differences utilization of primary prevention ICDs survival free from sustained arrhythmia (VA) ARVC. Methods was a retrospective analysis ARVC patients without prior VA enrolled clinical registries 11 countries throughout Europe North America. Patients were...
Abstract Background and Aims Pathogenic variants in the desmoplakin (DSP) gene are associated with development of a distinct arrhythmogenic cardiomyopathy phenotype not fully captured by either dilated (DCM), non-dilated left ventricular (NDLVC), or right (ARVC). Prior studies have described baseline DSP genetic, inflammatory, structural characteristics. However, cohort sizes limited full clinical characterization identification demographic predictors sustained arrhythmias (VAs), heart...
BackgroundEpidemiological evidence suggests that anti-inflammatory and immunomodulatory properties of statins may reduce the risk infections infection-related complications.ObjectiveWe aimed to assess impact prior statin use on coronavirus disease (COVID-19) severity mortality.MethodsIn this observational multicenter study, consecutive patients hospitalized for COVID-19 were enrolled. In-hospital mortality assessed with National Early Warning Score (NEWS) deemed primary secondary outcomes,...
BackgroundSince the body of evidence addressing coagulation derangements caused by Coronavirus disease (COVID-19) has been constantly growing, we investigated whether pre-hospitalization oral anticoagulation (OAC) or in-hospital heparin treatment could have a protective role among COVID-19 patients.MethodIn this cohort study, consecutive patients admitted to four different Italian Institutions were enrolled. Baseline demographic, clinical, laboratory, and radiological characteristics, as...
Pulmonary vein isolation (PVI) either by balloon devices or radiofrequency forms the cornerstone of invasive atrial fibrillation (AF) treatment. Although equally effective cryoballoon (CB)-based PVI offers shorter procedure duration and a better safety profile. Beside worldwide established Arctic Front Advance system, novel CB device, POLARx, was recently introduced. This incorporates unique features, which may translate into improved efficacy safety. However, multicentre assessment...
A novel risk calculator based on clinical characteristics and noninvasive tests that predicts the onset of sustained ventricular arrhythmias (VA) in patients with arrhythmogenic right cardiomyopathy (ARVC) has been proposed validated by recent studies. It remains unknown whether programmed stimulation (PVS) provides additional prognostic value.All a definite ARVC diagnosis, no history VAs at PVS performed baseline were extracted from 6 international registries. The calculator-predicted for...
Manual compression (MC), widely used to achieve venous access haemostasis, needs prolonged immobilization and extended time-to-haemostasis. Vascular closure devices (VCD) have been reported significantly shorter time haemostasis ambulation in arterial access-site management. The current study aimed evaluate the safety efficacy as well rate of urinary tract complications patients receiving MC vs. VCD for closure.A total 803 consecutive undergoing catheter ablation or left atrial appendage...