A5066210822- Cardiac Arrhythmias and Treatments
- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Cardiac pacing and defibrillation studies
- Cardiac electrophysiology and arrhythmias
- Mitochondrial Function and Pathology
- Advanced MRI Techniques and Applications
- Atrial Fibrillation Management and Outcomes
- Cardiomyopathy and Myosin Studies
- Ion channel regulation and function
- Cardiovascular Effects of Exercise
- Cardiac Valve Diseases and Treatments
- Cardiac Structural Anomalies and Repair
- Adipose Tissue and Metabolism
- ATP Synthase and ATPases Research
- Nitric Oxide and Endothelin Effects
- Sarcoidosis and Beryllium Toxicity Research
- Cardiac Ischemia and Reperfusion
- Heart Rate Variability and Autonomic Control
- Venous Thromboembolism Diagnosis and Management
- Hormonal Regulation and Hypertension
- ECG Monitoring and Analysis
- Electron Spin Resonance Studies
- Coronary Interventions and Diagnostics
- Infective Endocarditis Diagnosis and Management
Hamamatsu University School of Medicine
2015-2024
Nippon Medical School
2020
Otsuka (Japan)
2020
Hirosaki University
2016
Hamamatsu University
2008-2014
Red Cross Hospital
2014
Hamamatsu University Hospital
2014
General Department of Preventive Medicine
2005-2013
Stanford University
2013
Yamaha (Japan)
2013
Background: Cryoballoon-based pulmonary vein isolation (PVI) has emerged as an effective treatment for atrial fibrillation. The most frequent complication during cryoballoon-based PVI is phrenic nerve injury (PNI). However, data on PNI are scarce. Methods: YETI registry a retrospective, multicenter, and multinational evaluating the incidence, characteristics, prognostic factors recovery follow-up of patients with PVI. Experienced electrophysiological centers were invited to participate. All...
Reactive oxygen species (ROS) production during ischemia-reperfusion (I/R) is thought to be a critical factor for myocardial injury. However, small amount of ROS the ischemic preconditioning (IPC) may provide signal cardioprotection. We have previously reported that repetitive pretreatment [hydrogen peroxide (H(2)O(2)), 2 microM] mimicked IPC-induced cardioprotection in Langendorff-perfused rat hearts. further investigated mechanisms ROS-induced against I/R injury and tested hypothesis...
Although mitochondrial oxidative catabolism of fatty acid (FA) is a major energy source for the adult mammalian heart, cardiac lipotoxity resulting from elevated serum FA and enhanced use has been implicated in pathogenesis heart failure. To investigate effects intermediates metabolism [palmitoyl-l-carnitine (Pal-car) palmitoyl-CoA (Pal-CoA)] on function, we measured membrane potential (ΔΨ m ), opening permeability transition pore (mPTP), production ROS saponin-treated rat ventricular...
We present a case of pulmonary arterial hypertension (PAH), which is potentially related to treatment with dasatinib (Sprycel(®)). A 61-year-old woman, who had been treated for 27 months chronic myeloid leukemia (CML), visited our hospital complaining dyspnea. In right heart catheterization, her mean pressure was 35 mmHg. After other possible etiologies cause PAH were excluded, the patient diagnosed as dasatinib-related PAH. As notified by U.S. Food and Drug Administration (FDA) in October...
Purpose To examine how left ventricular (LV) volume and function affect flow dynamics by analyzing 3D intra-LV vortex features using 4D-Flow. Materials Methods Twenty-one patients with preserved (LVEF > 60%) 14 impaired LV < 40%) underwent 4D-Flow (at 3T). Results In function, the vortices developed in both early late diastolic phases. The shift of inflow vectors at basal toward posterior-lateral side mid-ventricular turn outflow could explain clearer formation phase. during phase located...
Cardiac involvement in systemic sclerosis (SSc) is considerably frequent autopsy, but the early identification clinically difficult. Recent advantages cardiac magnetic resonance (CMR) enabled to detect myocardial fibrotic scar as late gadolinium enhancement (LGE). We aimed examine prevalence and distribution of LGE patients with SSc, associate them clinical features, electrocardiographic abnormalities function. Forty SSc (58 ± 14 years-old, 35 females, limited/diffuse 25/15, disease duration...
Background:The intra-left atrial (LA) blood flow from pulmonary veins (PVs) to the left ventricle (LV) changes under various conditions and might affect global cardiac function. By using phase-resolved 3-dimensional cine phase contrast magnetic resonance imaging (4D-Flow), intra-LA vortex formation was visualized factors affecting dynamics were examined.Methods Results:Thirty-two patients with or without organic heart diseases underwent 4D-Flow transthoracic echocardiography. The velocity...
AimsHypoxia, ischaemia, and exogenous chemicals can induce extracellular intracellular acidosis, but it is not clear which of these types acidosis affects endothelial cell function. The synthesis release endothelium-derived relaxing factors (EDRFs) are linked to an increase in cytosolic Ca2+ concentration, we therefore examined the effects on responses EDRF production cultured porcine aortic cells.
Pulmonary vein isolation has become a cornerstone treatment for catheter ablation of atrial fibrillation (AF). Recent reports show that additional targeting low-voltage zones reduces AF recurrence. However, the pre-procedural predictors remain elusive. We retrospectively enrolled 359 patients (mean age 63.7 ± 10.8 years; 73 females; and 149 had persistent fibrillation) who underwent left (LA) voltage mapping during sinus rhythm or pacing. Low-voltage were defined as area > 5 cm 2 with...
Background The identification of protein kinase A (PKA) anchoring proteins on mitochondria implies a direct effect PKA mitochondrial function. However, little is known about the relationship between and metabolism. Methods Results effects redox state (flavin adenine dinucleotide (FAD)), membrane potential (Δψm) reactive oxygen species (ROS) production were investigated in saponin-permeabilized rat cardiomyocytes. catalytic subunit (PKAcat; 50 unit/ml) increased FAD intensities by 56.6±7.9%...
Aldosterone has non-genomic effects that express within minutes and modulate intracellular ion milieu cellular function. However, it is still undefined whether aldosterone actually alters concentrations or contractility. To clarify the of aldosterone, we measured [Na+]i, Ca2+ transient (CaT), cell volume in dye-loaded rat ventricular myocytes, also evaluated myocardial We found following: (i) increased [Na+]i at 100 nmol/L to 10 micromol/L; (ii) (up micromol/L) did not alter CaT shortening...
Background: Microtubule (MT) disorganization is related to cardiac disorders. To elucidate the mechanism by which of MT network deteriorates function, relationship between and mitochondrial permeability transition pore (mPTP) in myocytes was investigated. Methods Results: The effects stabilization (by paclitaxel) disruption nocodazole) on membrane potential (ΔΨm) opening mPTP were measured permeabilized Sprague-Dawley rat myocytes. Both paclitaxel nocodazole depolarized ΔΨm opened mPTP. When...