A5015738864- Glioma Diagnosis and Treatment
- Lung Cancer Diagnosis and Treatment
- Brain Metastases and Treatment
- Schizophrenia research and treatment
- Lung Cancer Treatments and Mutations
- Renal Transplantation Outcomes and Treatments
- Transplantation: Methods and Outcomes
- Hematopoietic Stem Cell Transplantation
- Adrenal and Paraganglionic Tumors
- Aortic aneurysm repair treatments
- Multiple Sclerosis Research Studies
- Cancer, Hypoxia, and Metabolism
- Intensive Care Unit Cognitive Disorders
- Cerebral Palsy and Movement Disorders
- Aortic Disease and Treatment Approaches
- Gastric Cancer Management and Outcomes
- Respiratory Support and Mechanisms
- Homelessness and Social Issues
- Radiomics and Machine Learning in Medical Imaging
- Preterm Birth and Chorioamnionitis
- Pancreatic and Hepatic Oncology Research
- Hormonal Regulation and Hypertension
- Sepsis Diagnosis and Treatment
- Esophageal Cancer Research and Treatment
- Respiratory viral infections research
Aix-Marseille Université
2016-2025
Assistance Publique Hôpitaux de Marseille
2015-2024
Hôpital de la Timone
2006-2021
RELX Group (United States)
2020
Ceres
2020
Délégation Provence et Corse
2016-2019
Public Health Department
2005-2018
Hôpital Nord
2013-2017
Inserm
2003-2017
Institut de Recherche pour le Développement
2015-2017
In patients undergoing mechanical ventilation for the acute respiratory distress syndrome (ARDS), neuromuscular blocking agents may improve oxygenation and decrease ventilator-induced lung injury but also cause muscle weakness. We evaluated clinical outcomes after 2 days of therapy with in early, severe ARDS.
Professional burnout is a psychological syndrome arising in response to chronic interpersonal stressors on the job. There perception that intensivists are particularly exposed stress because lives literally their hands.To evaluate prevalence and associated factors (patients or organization) of among physicians working intensive care units (ICUs) (including interns, residents, fellows, attending physicians).A 1-day national survey was conducted adult ICUs French public hospitals.The level...
To assess efficacy and safety of rituximab (RTX) as induction therapy, maintenance remission treatment relapses in a cohort IgG4-related disease (IgG4-RD) patients.Nationwide retrospective multicenter study IgG4-RD patients treated with at least one course RTX. Clinical, biological radiological response, relapse rate drug tolerance were analyzed. Kaplan-Meier curves plotted risk factors for studied Cox regression model.Among 156 included the French database, 33 received rituximab. Clinical...
<h3>Importance</h3> Sedative premedication is widely administered before surgery, but little clinical evidence supports its use. <h3>Objective</h3> To assess the efficacy of sedative on perioperative patient experience. <h3>Design, Setting, and Participants</h3> A randomized trial, PremedX study, enrolled 1062 adult patients who were younger than 70 years had been scheduled for various elective surgeries under general anesthesia at 5 French teaching hospitals (in Marseille, Montpellier,...
Epigenetic modifications may contribute to the development and progression of cancer. We investigated whether epigenetic changes involving multiple histones influence prognosis non-small-cell lung cancer (NSCLC) patients.We used immunohistochemistry assess histone 3 lysine 4 dimethylation (H3K4diMe), acetylation 2A 5 (H2AK5Ac), 2B 12, 9 (H3K9Ac), 8 in resected tumor samples 138 NSCLC patients. Data were analyzed using a recursive partitioning analysis (RPA).The RPA classified patients into...
To date, it remains impossible to guarantee that short-term treatment given a patient suffering from major depressive episode (MDE) will improve long-term efficacy. Objective biological measurements and biomarkers could help in predicting the clinical evolution of MDE are still warranted. better understand reason nearly half patients respond poorly current antidepressive treatments, we examined gene expression profile peripheral blood samples collected 16 severe 13 matched controls. Using...
Abstract Pediatric cortical glioneuronal benign tumors mainly include gangliogliomas ( GG ) [differential diagnoses pilocytic astrocytomas PA and pleomorphic xanthoastrocytomas PXA )] dysembryoplastic neuroepithelial tumor DNT ). the specific form controversial non‐specific that lack element. Our aims were to search for BRAF V600E mutation CD 34 expression in , correlate with evaluate their diagnostic prognostic values. Ninety‐six children included. was studied by sequencing...
Background. Bacterial vaginosis is a risk factor for preterm birth. The various conventional methods its diagnosis are laborious and not easily reproducible. Molecular quantification have been reported recently, but the specific factors they might identify remain unclear. Methods. A prospective multicenter national study included pregnant women at of quantitative molecular tool using real-time polymerase chain reaction assay serial dilutions plasmid suspension quantified Atopobium vaginae,...
About 1% of patients admitted to the Emergency Department (ED) have hypernatremia, a condition associated with mortality rate 20 60%. Management recommendations originate from intensive care unit studies, in which and medical diseases differ those ED.We retrospectively studied clinical characteristics, treatments, outcomes severely hypernatremic ED risk factors death occurrence during hospitalization.During 2010, 85 cases severe hypernatremia ≥ 150 mmol/l were ED. Hypernatremia occurred...
Patients with schizophrenia (SCZ) represent a vulnerable population who have been understudied in COVID-19 research. We aimed to establish whether health outcomes and care differed between patients SCZ without diagnosis of severe mental illness. conducted population-based cohort study all identified respiratory symptoms were hospitalized France February June 2020. Cases had SCZ. Controls did not The in-hospital mortality intensive unit (ICU) admission. A total 50 750 included, whom 823...
We examine and characterize subsets of circulating lymphocytes in untreated patients with active IgG4-related disease (IgG4-RD). Twenty eight consecutive proven IgG4-RD were included a prospective, multicentric study. Lymphocytes analyzed by flow cytometry, analysis TH1/TH2/TH17, TFH cells cytokine release peripheral blood mononuclear cells. Results compared healthy controls primary Sjogren syndrome. Patients characterized an increase T regulatory cells, TH2, TH17 the CD4+CXCR5+PD1+ subset....